One of the most sustainable and promising approaches for hydrogen peroxide (H2 O2 ) production in a low-cost environment-friendly way is photosynthesis, which, however, suffers from poor carrier utilization low H2 productivity. The addition proton donors such as isopropanol or ethanol can increase production, unfortunately, will inevitably elevate entire cost while wasting oxidizing power holes (h+ ). Herein, tetrahydroisoquinolines (THIQs) employed distinctive donor thermodynamically...

A honeycomb-like PtAu alloy catalyst has been developed to modulate the adsorption capacity of OH − species and configuration glycerol on surface for electrocatalytic upgrading C 3 chemicals.

The widespread accumulation of nanoplastics is a growing concern for the environmental and human health. However, studies on mechanisms nanoplastic-induced developmental toxicity are still limited. Here, we systematically investigated potential biological roles nanoplastic exposure in zebrafish during early stage. embryos were subjected to 100 nm polystyrene with different concentrations (0, 100, 200, 400 mg/L). results indicated that could decrease hatching survival rates embryos. In...

The global accumulation and adverse effects of nanoplastics (NPs) are a growing concern for the environment human health. In recent years, more studies have begun to focus on toxicity plastic particles early animal development. Different particle sizes different toxicities biological Nevertheless, potential toxicological 20 nm NPs, especially neurodevelopment, not been well investigated. this paper, we used fluorescence microscopy determine neurotoxicity in zebrafish at concentrations NPs....

The mitochondria DNA (mtDNA) editing tool, zinc finger nucleases (ZFNs), transcription activator-like effector nuclease (TALENs), and clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9 (CRISPR/Cas9) system, is a promising approach for the treatment of mtDNA diseases by eliminating mutant mitochondrial genomes. However, there have been no reports repairing with homologous recombination strategy to date. Here, we show mito-CRISPR/Cas9 system that mito-Cas9...

Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) resistance is a major obstacle in the treatment of non-small cell lung cancer (NSCLC). Epigenetic alterations have been shown to be involved NSCLC oncogenesis; however, their function EGFR-TKI remains uncharacterized. Here, we found that an EHMT2 inhibitor, UNC0638, can significantly inhibit and induce apoptosis EGFR-TKI-resistant cells. Additionally, also expression enzymatic activity levels were elevated Moreover,...

Sliver nanoparticles (AgNPs) are widely used in industry, agriculture, and medicine, potentially resulting adverse effects on human health aquatic environments. Here, we investigated the developmental toxicity of zebrafish embryos with acute exposure to AgNPs. Our results demonstrated defects 4 hpf after different concentrations AgNPs for 72 h. In addition, RNA-seq profiling treatment. Further Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses showed that...

The base excision repair (BER) pathway is an important defense response to oxidative DNA damage. It known that exposures phthalate esters (PAEs), including Dibutyl (DBP), Mono-(2-ethylhexyl) (MEHP), and Di-(2-ethylhexyl) (DEHP), cause reactive oxygen species-induced damage stress. Here, we determined the mRNA levels of BER pathway-related genes (ogg1, nthl1, apex1, parp1, xrcc1, lig3, ung, pcna, polb, pold, fen1, lig1), pro-apoptotic gene (bax), apoptotic suppressor (bcl2) in different...

Abstract Current research has shown an increasing acceptance of interventions for depression through dietary modifications. However, whether composite antioxidant index (CDAI) is associated with and all-cause mortality in middle-aged elderly population remains unknown. This study aimed to explore those associations American population. Weighted logistic regression models weighted Cox proportional hazard were used assess the association CDAI, covariates, depression, mortality, respectively....

Brain and neurons are particularly sensitive to reactive oxygen species (ROS). Oxidative damage from ROS results in increased 8-oxoguanine DNA followed by repair through the base excision (BER) pathway. We reported earlier that AP endonuclease 1 (Apex1) not only participates directly BER but also regulates transcription factor Creb1. Here, we investigated how Apex1 affects brain respond effectively oxidative during zebrafish development. Loss of resulted ROS, 8-oxoguanine, abasic sites as...

Heparanase is an endo‐β‐ d ‐glucuronidase that cleaves heparan sulfate (HS) side chains of proteoglycans. Compelling evidence tie heparanase levels with all steps tumor formation including initiation, growth, metastasis and chemo‐resistance, likely involving augmentation signaling pathways gene transcription. In order to reveal the molecular mechanism(s) underlying protumorigenic properties heparanase, we established inducible (Tet‐on) system in U87 human glioma cells applied array...

Highlights•VEGF-A stimulation induces cGAS nuclear translocation via importin-β pathway•Nuclear modulates VEGF-A-mediated angiogenesis regulating miR-212-5p-ARPC3 cascade•cGAS loss impairs trans-Golgi network-involved VEGFR2 trafficking•Nuclear of is associated with human pathologySummaryCyclic GMP-AMP synthase (cGAS) senses cytosolic incoming DNA and consequently activates stimulator interferon response cGAMP interactor 1 (STING) to mount immune response. Here, we show could regulate in an...

Both molecular conformations and hole–electron distribution impacted by the solvent polarity, can cause an enhanced or reduced emission of TPP structures, which provides a general intramolecular charge transfer rule guidelines for PEE.

Introduction: Silver nanoparticles (AgNP) are widely used as coating materials. However, the potential risks of AgNP to human health, especially for neural and vascular systems, still poorly understood. Methods: The neurotoxicity various concentrations in zebrafish were examined using fluorescence microscopy. In addition, Illumina high-throughput global transcriptome analysis was performed explore profiles embryos after exposure AgNP. Kyoto Encyclopedia Genes Genomes (KEGG) enrichment...

Abstract High‐quality near‐ultraviolet/deep‐blue organic emitters are urgently needed but still rare. Here, three V‐shape donor‐acceptor‐donor (D‐A‐D) based on pyrazine cores, namely, VDMP‐PhCz, VDMP‐36PhCz, and VDMP‐TPA, designed synthesized. Their doped devices using a high‐polar host show remarkable electroluminescence (EL) performances with maximum external quantum efficiency (EQE) values up to 7.37%, 7.55%, 9.03%, corresponding CIE coordinates of (0.160,0.040), (0.161,0.039),...

Whey protein isolate (WPI)-based nanodelivery systems have recently attracted an increasing amount of attention. Despite this, research focusing on milk concentrate (MPC) and micellar casein (MCC) as carriers loaded in hydrophobic compounds is lacking. This study investigated the mediated effect docosahexaenoic acid (DHA) 3 different proteins for embedding astaxanthin (ASTA) after ultrasound-assisted pH-shifting treatment. We then evaluated application cheese processing by comparing MPC,...

Numerous feasible methods for inserting large fragments of exogenous DNA sequences into the zebrafish genome have been developed, as has editing technology using programmable nucleases. However, coding targeted endogenous genes are disrupted, and expression patterns inserted cannot completely recapitulate those genes. Here we describe establishment a novel strategy promoter-driven microhomology-mediated end-joining-dependent integration donor vector clustered regularly interspaced short...

Roxithromycin (ROX), a commonly used macrolide antibiotic, is extensively employed in human medicine and livestock industries. Due to its structural stability resistance biological degradation, ROX persists as resilient environmental contaminant, detectable aquatic ecosystems food products. However, our understanding of the potential health risks humans from continuous exposure remains limited. In this study, we zebrafish vertebrate model explore developmental toxicity early exposure,...