A5054419148- Oral microbiology and periodontitis research
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Bone Metabolism and Diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Trace Elements in Health
- Inflammatory mediators and NSAID effects
- S100 Proteins and Annexins
- Legionella and Acanthamoeba research
- MicroRNA in disease regulation
- Oral Health Pathology and Treatment
- Orthopaedic implants and arthroplasty
- Redox biology and oxidative stress
- Pesticide Exposure and Toxicity
- Computational Drug Discovery Methods
- ATP Synthase and ATPases Research
- Salivary Gland Disorders and Functions
- Calpain Protease Function and Regulation
- Flavonoids in Medical Research
- Nanoparticles: synthesis and applications
- Genomics, phytochemicals, and oxidative stress
- Ovarian function and disorders
- Silymarin and Mushroom Poisoning
- Glutathione Transferases and Polymorphisms
- Reproductive System and Pregnancy
Wenzhou Medical University
2018-2025
Guangxi Medical University
2025
Shantou University Medical College
2023
Harbin Medical University
2023
First Affiliated Hospital of Harbin Medical University
2023
Nanjing Medical University
2022-2023
Shantou University
2023
Osteoblasts dysfunction, induced by oxidative stress (OS), is one of major pathological mechanisms for osteoporosis. Curcumin (Cur), a bioactive antioxidant compound, isolated from longa L, was regarded as strong reactive oxygen species (ROS) scavenger. However, it remains unveiled whether Cur can prevent osteoblasts OS-induced dysfunction. To approach this question, we adopted well-established OS model to investigate the preventive effect on dysfunction measuring intracellular ROS...
As a gasotransmitter, carbon monoxide (CO) possesses antitumor activity by reversing the Warburg effect at higher concentrations. The targeted delivery of monoxide-releasing molecules (CORMs) using nanomaterials is an appealing option for CO administration, but how to maintain above threshold concentration in tumor tissue remains challenge. Herein, nanozyme-catalyzed cascade reaction proposed promote release high-efficacy photothermal therapy (PTT)-combined cancer. A gold-based porphyrinic...
Sperm motility can be enhanced by adding ATP exogenously during in vitro fertilization. However, administering exogenous to the testis improve sperm for vivo asthenozoospermia treatment has not been investigated yet. Inspired recent advances nanomedicine, we whether capability of drug delivery nanocarriers traverse blood–testis barrier (BTB) facilitate ATP-dependent treatment. We found that human H-ferritin (HFn) nanocarrier possesses BTB and specifically targets head elongated cells....
Periodontitis is an oral microbiota-induced inflammatory disease, in which inflammation and oxidative stress play a critical role. Silibinin (SB), Silybum marianum-derived compound, exhibits strong anti-inflammatory antioxidative properties. We adopted rat ligature-induced periodontitis model lipopolysaccharide- (LPS-) stimulated human periodontal ligament cells (hPDLCs) to evaluate the protective effects of SB. In vivo model, SB reduced alveolar bone loss apoptosis PDLCs tissue. also...
To investigate whether silibinin impacts diabetic periodontitis (DP) via mitochondrial regulation.In vivo, rats were divided into control, diabetes, DP and combined with groups. Diabetes induced by streptozocin silk ligation, respectively. Bone turnover was evaluated microcomputed tomography, histology immunohistochemistry. In vitro, human periodontal ligament cells (hPDLCs) exposed to hydrogen peroxide (H2 O2 ) or without silibinin. Osteogenic function analysed Alizarin Red alkaline...
Introduction: Silver nanoparticles (AgNP) are widely used as coating materials. However, the potential risks of AgNP to human health, especially for neural and vascular systems, still poorly understood. Methods: The neurotoxicity various concentrations in zebrafish were examined using fluorescence microscopy. In addition, Illumina high-throughput global transcriptome analysis was performed explore profiles embryos after exposure AgNP. Kyoto Encyclopedia Genes Genomes (KEGG) enrichment...
Abstract Periodontitis is a common oral disease characterized by progressive alveolar bone resorption and inflammation of the periodontal tissues. Dimethyl fumarate (DMF) has been used in treatment various immune-inflammatory diseases due to its excellent anti-inflammatory antioxidant functions. Here, we investigated for first time therapeutic effect DMF on periodontitis. In vivo studies showed that significantly inhibited destruction, enhanced mitophagy, decreased M1/M2 macrophage ratio....
Myoblast differentiation is a crucial process for myogenesis. Mitochondria function as an energy-providing machine that critical to this process, and mitochondrial dysfunction can prevent myoblasts from fusing into myotubes. However, the molecular mechanisms underlying dynamic regulation of networks remain poorly understood. In present study, we found PTEN induced kinase 1 (PINK1)/Parkin (an E3 ubiquitin-protein ligase) pathway activated at early stage myoblast differentiation. Moreover,...
Mitochondria are essential for cell growth, fission, differentiation, and survival, particularly in undivided cells with high energy requirements, such as cardiomyocytes. The morphology position of mitochondria change the activity mitochondrial fission proteins fusion proteins. These regulatory mechanisms substantially affect cardiomyocyte supply normal function. In dynamin-related protein 1 (Drp1) is involved separation degradation damaged mitochondria, accurately regulates renewal number....
Background: Reactive oxygen species (ROS) overproduction promotes the alveolar bone loss during development of periodontitis. Mitochondria are principal source ROS. Hydroxytyrosol (HT) is well known for its antioxidant and mitochondrial-protective prosperities. Nonetheless, impact HT on periodontitis related mechanisms underlying cell behavior remains unknown.Methods: Osteoclasts differentiated from RAW264.7 model oxidative stress (OS) induced pre-osteoblast MC3T3-E1 injury were treated with...