A5102022432- Antibiotic Resistance in Bacteria
- Hearing, Cochlea, Tinnitus, Genetics
- Bacterial biofilms and quorum sensing
- Plasma Applications and Diagnostics
- Bacteriophages and microbial interactions
- Plasma Diagnostics and Applications
- Mycobacterium research and diagnosis
- Antimicrobial Resistance in Staphylococcus
- Connexins and lens biology
- Infections and bacterial resistance
- Microbial infections and disease research
- Antibiotics Pharmacokinetics and Efficacy
- Plant Pathogenic Bacteria Studies
- Bacterial Genetics and Biotechnology
- Genomics and Phylogenetic Studies
- Vestibular and auditory disorders
- Hearing Loss and Rehabilitation
- Electrohydrodynamics and Fluid Dynamics
- Pharmaceutical and Antibiotic Environmental Impacts
- Microbial Natural Products and Biosynthesis
- Sinusitis and nasal conditions
- Ion Channels and Receptors
- Genomics and Rare Diseases
- Immune Response and Inflammation
- Microbial Metabolism and Applications
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2025
Xuzhou Medical College
2025
Jinzhou Medical University
2025
Laboratoire Plasma et Conversion d'Energie
2017-2024
Institut National Polytechnique de Toulouse
2017-2024
École Nationale Supérieure d'Électrotechnique, d'Électronique, d'Informatique, d'Hydraulique et des Télécommunications
2017-2024
Columbia University
2024
Shaanxi History Museum
2024
Wenzhou Medical University
2013-2023
University of Hohenheim
2023
Hearing impairment due to the loss of sensory hair cells is permanent in humans. Considerable interest targets cell differentiation factor Atoh1 as a potential tool with which promote regeneration. We generated novel mouse model direct expression spatially and temporally specific manner postnatal mammalian cochlea determine competency various types cochlear epithelial for differentiation. can generate young animals morphological, molecular, physiological properties reminiscent cells. This...
Dysfunction of gap junctions (GJs) caused by mutations in connexin26 (Cx26) and Cx30 accounts for nearly half all cases hereditary nonsyndromic deafness cases. Although it is widely held that GJs connecting supporting cells the organ Corti mainly provide ionic pathways rapid removal K + around base hair cells, function cochlea remains unknown. Here we show were not assembled until 3 days after birth mice then gradually matured to connect before onset hearing. In organotypic cochlear cultures...
Connexin26 (Cx26) and connexin30 (Cx30) are two major protein subunits that co-assemble to form gap junctions (GJs) in the cochlea. Mutations either one of them cause non-syndromic prelingual deafness humans. Because mechanisms cochlear pathogenesis caused by Cx mutations unclear, we investigated effects Cx30 null mutation on GJ-mediated ionic metabolic coupling cochlea mice. A novel flattened preparation was used directly assess intercellular sensory epithelium Double-electrode patch clamp...
Bacterial resistance to the antibiotics has become an important concern for public health. This study was aimed investigate characteristics and distribution of florfenicol-related genes in bacteria isolated from 4 farms. A total 106 florfenicol-resistant Gram-negative bacilli were examined positive isolates further characterized. Antimicrobial sensitivity results showed that most them (100, 94.33%) belonged multidrug Enterobacteriaceae. About 91.51% strains carried floR gene, 4.72% cfr gene....
To study the detailed nature of genomic microevolution during mixed infection with multiple Helicobacter pylori strains in an individual.We sampled 18 isolates from a single biopsy patient chronic gastritis and nephritis. Whole-genome sequencing was applied to these isolates, statistical genetic tools were used investigate their evolutionary history.The genomes fall into two clades, reflecting colonisation stomach by distinct strains, lineages have accumulated diversity estimated 2.8 4.2...
Connexins (Cxs) are a family of protein subunits constituting gap junctions, which facilitate exchanges molecules important for cellular signaling and metabolic activities intercellularly or between different regions the cytoplasm in same cells. Mutations Cxs major cause nonsyndromic childhood deafness, mostly found Cx26 Cx30 expressed cochlear supporting cells fibrocytes. So far, little is known about functional contribution other types Here, we show that Cx29 was highly cochlea. The...
Neurotrophins (NTs) play essential roles in the development and survival of neurons PNS CNS. In cochlea, NTs [e.g., NT-3, brain-derived neurotrophic factor (BDNF)] are required for spiral ganglion (SGNs). Preservation SGNs cochlea patients suffering sensorineural deafness caused by loss hair cells is needed optimal performance cochlear implant. Directly applying exogenous BDNF into prevents secondary degeneration when lost. However, a common translational barrier <i>in vivo</i> applications...
Photodynamic therapy (PDT) has emerged as a potent novel therapeutic modality that induces cell death through light-induced activation of photosensitizer. But some photosensitizers have characteristics poor water-solubility and non-specific tissue distribution. These become main obstacles PDT. In this paper, we synthesized targeting drug delivery system (TDDS) to improve the photosensitizer enhance ability targeted TFR positive tumor cells. TDDS is transferrin-modified...
Shiraia bambusicola is a species of the monotypic genus in phylum Ascomycota. In China, it known for its pharmacological properties that are used to treat rheumatic arthritis, sciatica, pertussis, tracheitis and so forth. Its major medicinal active metabolite hypocrellin A, which exhibits excellent antiviral antitumor properties. However, genes involved A anabolic pathways were still unknown due lack genomic information this species. To investigate putative biosynthesis determine pathway, we...
Ion channels in the degenerin-epithelial sodium channel (DEG-ENaC) family perform diverse functions, including mechanosensation. Here we explored role of vertebrate DEG-ENaC protein, acid-sensing ion 2 (ASIC2), auditory transduction. Contributions ASIC2 to hearing were examined by comparing threshold and noise sensitivity wild-type null mice. mice showed no significant loss, indicating that was not directly involved mechanotransduction mammalian cochlea. However, found (1) present spiral...
The release of HA from PLGA/HA NPs was carried by dissolving in artificial gastric (pH 1.5), intestinal 6.8) and blood 7.4) media.
PurposePathogenic variants in SETD1B have been associated with a syndromic neurodevelopmental disorder including intellectual disability, language delay, and seizures. To date, clinical features described for 11 patients (likely) pathogenic sequence variants. This study aims to further delineate the spectrum of SETD1B-related syndrome based on characterizing an expanded patient cohort.MethodsWe perform in-depth characterization cohort 36 unpublished individuals variants, describing their...
Background: Diabetic retinopathy (DR) and diabetic cataract (DC) are two closely related microvascular complications of diabetes. Panax notoginseng, a plant from the Araliaceae family genus Panax, is widely used in traditional Chinese medicine (TCM) due to its antioxidant, anti-inflammatory, blood circulation-promoting properties. Recent studies suggest that drugs possessing characteristics may have unexpected benefits treating complications. This study employs network pharmacology...
Abstract Background With the wide use of florfenicol to prevent and treat bacterial infection domestic animals, emergence resistance bacteria is increasingly serious. It very important elucidate molecular mechanism bacteria’s florfenicol. Methods The minimum inhibitory concentration (MIC) levels were determined by agar dilution method, polymerase chain reaction was conducted analyze distribution genes in 39 CoNS strains isolated from poultry livestock animals seafood. whole genome sequence...
The presence and emergence of multiple species/subspecies ECC have led to diversity complications at the taxonomic level, which impedes our further understanding epidemiology clinical significance ECC. Accurate identification species is extremely important.
Abstract Recent studies have suggested that dogs were domesticated during the Last Glacial Maximum (LGM) in Siberia, which contrasts with previous proposed domestication centers (e.g. Europe, Middle East, and East Asia). Ancient DNA provides a powerful resource for study of mammalian evolution has been widely used to understand genetic history domestic animals. To maternal Asian dogs, we made complete mitogenome dataset 120 canids from 38 archaeological sites, including 102 newly sequenced...
Aim/Background To examine the impact of navel moxibustion, a form herb-partitioned moxibustion applied at belly button, on Brain-Derived Neurotrophic Factor (BDNF), Tyrosine Kinase receptor B (TrkB) and 5-Hydroxytryptamine (5-HT) levels in rats with PCPA-induced insomnia. Additionally, to investigate mechanism by which improves Materials Methods 27 Specific Pathogen Free (SPF)-grade male three-month- old SD were randomly divided weight into normal group, model group group. Except for latter...
The PLGA/HA NPs showed improved dispersibility and enhanced photostability, while maintaining high phototoxicity ROS production ability.
This work focuses on the investigation of memory effect origin in atmospheric pressure Townsend discharges nitrogen/oxidizing gas mixtures. For this purpose, an experimental approach is used a plane-to-plane dielectric barrier discharge, using short exposure time photographs discharge with interference filters, synchronized current. A segmented electrode into eight strips allows to correlate current and light emissions from different species space (position along flow). The results highlight...
Staphylococcus caprae, capitis and epidermidis belong to the "Epidermidis Cluster Group" (ECG) are generally opportunistic pathogens. In this work, whole genome sequencing, molecular cloning pan-genome analysis were performed investigate genetic characteristics of resistance, virulence structures 69 ECG strains, including a clinical isolate (S. caprae SY333) obtained in work. Two resistance genes (blaZ aadD2) encoded on plasmids pSY333-41 pSY333-45 S. SY333 confirmed be functional. The bla...
Delftia tsuruhatensis has become an emerging pathogen in humans. There is scant information on the genomic characteristics of this microorganism. In study, we determined complete genome sequence a clinical D. strain, TR1180, isolated from sputum specimen female patient China 2019. Phylogenetic and average nucleotide identity analysis demonstrated that TR1180 member . exhibited resistance to β-lactam, aminoglycoside, tetracycline sulphonamide antibiotics, but was susceptible phenicols,...