A5087114298- Nanoplatforms for cancer theranostics
- Crystallization and Solubility Studies
- Bone Metabolism and Diseases
- X-ray Diffraction in Crystallography
- Microbial Inactivation Methods
- Nanocluster Synthesis and Applications
- Biofuel production and bioconversion
- Advanced Nanomaterials in Catalysis
- Carbon and Quantum Dots Applications
- Bone health and treatments
- Fermentation and Sensory Analysis
- Nanoparticle-Based Drug Delivery
- Garlic and Onion Studies
- Bone and Dental Protein Studies
- Luminescence and Fluorescent Materials
- Microbial Natural Products and Biosynthesis
- Supercapacitor Materials and Fabrication
- Listeria monocytogenes in Food Safety
- Liver Disease Diagnosis and Treatment
- Genomics and Phylogenetic Studies
- Aquaculture disease management and microbiota
- Nonlinear Optical Materials Studies
- Food composition and properties
- Alcohol Consumption and Health Effects
- Probiotics and Fermented Foods
China University of Mining and Technology
2024-2025
Inner Mongolia Medical University
2024-2025
Academy of Military Medical Sciences
2025
Northeastern University
2015-2024
Xi'an Medical University
2010-2024
Kunming University of Science and Technology
2024
National Institute for Communicable Disease Control and Prevention
2024
Sichuan Agricultural University
2023-2024
Max Stern Academic College of Emek Yezreel
2024
Johns Hopkins University
2024
Objectives: To investigate tumor necrosis factor alpha (TNF-a)-induced changes in osteogenic differentiation from mesenchymal stem cells (MSCs).Materials and methods: Blockade of nuclear factor-jB (NF-jB) was achieved ST2 murine MSCs via overexpression the NF-jB inhibitor, IjBa.Osteogenic induced IjBa-overexpressing normal when these were treated with TNF-a at various concentrations.Expression levels bone marker genes determined using real time RT-PCR ALP activity assay.In vitro...
Amino-functionalized fluorescent carbon dots have been prepared by hydrothermal treatment of glucosamine with excess pyrophosphate. The produced showed stabilized green emission fluorescence at various excitation wavelengths and pH environments. Herein, we demonstrate the surface energy transfer between amino-functionalized negatively charged hyaluronate gold nanoparticles. Hyaluronidase can degrade break down nanoparticles to inhibit transfer. developed dot/gold nanoparticle system be...
Protein kinase B (PKB/Akt) plays important roles in the regulation of lipid homeostasis, and impairment Akt activity has been demonstrated to be involved development non-alcoholic fatty liver disease (NAFLD). Previous studies suggest that cytochrome P4502E1 (CYP2E1) causal pathogenesis alcoholic (AFL). We hypothesized might impaired due CYP2E1-induced oxidative stress chronic ethanol-induced hepatic steatosis. In this study, we found steatosis was accompanied with reduced phosphorylation at...
Abstract Background Previous studies have indicated that chronic emotional stressors likely participate in the occurrence of cancers. However, direct evidence connecting stress and colorectal cancer development remains almost completely unexplored. Methods Chronic mouse model was used to investigate influence on tumorigenesis. Several major agonists antagonists adrenergic receptors were applied effects β-adrenergic signaling CRC. Chromatin immunoprecipitation assays (CHIP) binding p53 CEBPB...
The limited penetration of nanocarriers into tumors and the slow release drugs from these carriers to tumor cells are significant challenges in cancer therapy. In this study, we developed a novel drug delivery carrier derived mesoporous silica, dually modified with tumor-homing cyclic peptide iRGD (CRGDKGPDC) pH-responsive polymer poly(2-ethyl-2-oxazoline) (PEOz) for treating triple-negative breast cancer. selectively bound αvβ3 integrin receptor, which is specifically expressed MDA-MB-231...
Abstract Analysis of nucleosides and nucleotides is desirable in many biological studies, but the task analytically challenging due to high polarity analytes. In this study, resolution mixtures containing their mono‐, di‐ triphosphates was achieved using a porous graphitic carbon (PGC) stationary phase, Hypercarb, under conditions suitable for liquid chromatography/mass spectrometry (LC/MS). Different organic mobile phases modifiers were evaluated separation 16 optimized gradient elution...
Abstract A new phosphorescent dinuclear cationic iridium(III) complex ( Ir1 ) with a donor–acceptor–π‐bridge–acceptor–donor (DAπAD)‐conjugated oligomer L1 as N^N ligand and triarylboron compound C^N has been synthesized. The photophysical excited‐state properties of were investigated by UV/Vis absorption spectroscopy, photoluminescence molecular‐orbital calculations, they compared those the mononuclear [Ir(Bpq) 2 (bpy)] + PF 6 − Ir0 ). Compared , shows more‐intense optical‐absorption...
Specific detection or imaging protein has high potential to contribute greatly medical diagnosis, biological research, and therapeutic applications. The level of human serum albumin (HSA) in blood is related a variety diseases thus serves as an important biomarker for fast clinical diagnosis. Here we report the use aggregation-induced emission (AIE) based supramolecular assembly design biomolecular responsive smart organic nanomaterials HSA. designed nanoprobes were aggregates small...
ABSTRACT The dental cementum covering the tooth root is similar to bone in several respects but remains poorly understood terms of development and differentiation cementoblasts, as well potential function(s) cementocytes residing cellular cementum. It not known if cementocyte a dynamic actor metabolism, comparable osteocyte bone. Cementocytes exhibit irregular spacing lacunar shape, with fewer canalicular connections compared osteocytes. Immunohistochemistry quantitative PCR (qPCR) revealed...
Three carbazole dicationic salts, namely 3,6-bis(1-methyl-4-vinylpyridinium) diiodide (BMVC), 9-ethyl-3,6-bis(1-methyl-4-vinylpyridinium) (9E-BMVC) and 9-ethyl-3,6-bis(1-hydroxyethyl-4-vinylpyridinium)carbazole (9E-BHVC), were synthesized successfully. Their photophysical properties evaluated by absorption, one- two-photon fluorescence spectra, their higher intensity larger excited action cross-sections (Φ × δ) in the presence of DNA than those absence give them good light-switch properties....
Tobacco smoking is an important risk factor for the development of several cancers, osteoporosis, and inflammatory diseases such as periodontitis. Nicotine one major components tobacco. In previous study, we showed that nicotine inhibits mineralized nodule formation by osteoblasts, culture medium from osteoblasts containing lipopolysaccharide increases osteoclast differentiation. However, direct effect on differentiation function osteoclasts poorly understood. Thus, examined effects...