A5070927231- dental development and anomalies
- Bone Metabolism and Diseases
- Orthodontics and Dentofacial Orthopedics
- Oral microbiology and periodontitis research
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Electrochemical sensors and biosensors
- Axon Guidance and Neuronal Signaling
- Dental Radiography and Imaging
- Cancer-related molecular mechanisms research
- Oral and Maxillofacial Pathology
- Bone and Dental Protein Studies
- Periodontal Regeneration and Treatments
- Cleft Lip and Palate Research
- Dental Implant Techniques and Outcomes
- Salivary Gland Disorders and Functions
- Antimicrobial Peptides and Activities
- Sexual function and dysfunction studies
- Menstrual Health and Disorders
- Immunodeficiency and Autoimmune Disorders
- Dental Trauma and Treatments
- Oral and gingival health research
- Fibroblast Growth Factor Research
- Enzyme-mediated dye degradation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Sichuan University
2014-2025
State Key Laboratory of Oral Diseases
2014-2025
Xi'an Shiyou University
2021-2024
Stomatology Hospital
2024
University of Missouri–Kansas City
2015-2016
Abstract Polyphenol hydrogels have found widespread application in wound healing, bone repair, drug delivery, and biosensors due to their robust wet adhesion, high ductility, excellent self‐healing ability. However, these often exhibit low intrinsic cohesion, which limits overall adhesive strength. Enhancing cohesion is critical for improving both the adhesion mechanical properties of hydrogels, thereby expanding utility biomedical fields. This review begins by exploring strategies enhance...
ABSTRACT The dental cementum covering the tooth root is similar to bone in several respects but remains poorly understood terms of development and differentiation cementoblasts, as well potential function(s) cementocytes residing cellular cementum. It not known if cementocyte a dynamic actor metabolism, comparable osteocyte bone. Cementocytes exhibit irregular spacing lacunar shape, with fewer canalicular connections compared osteocytes. Immunohistochemistry quantitative PCR (qPCR) revealed...
Periodontitis patients are at risk of alveolar bone loss during orthodontic treatment. The aim this study was to investigate whether intermittent parathyroid hormone (1-34) treatment (iPTH) could reduce tooth movement (OTM) in individuals with periodontitis and the underlying mechanism. A rat model OTM context established observed. control, iPTH + stattic groups received injections vehicle, PTH or signal transducer activator transcription 3 (STAT3) inhibitor stattic, respectively. prevented...
Abstract Orthodontic tooth movement (OTM) is a highly coordinated biomechanical response to orthodontic forces with active remodelling of alveolar bone but minor root resorption. Such antiresorptive properties relate cementocyte mineralization, the mechanisms which remain largely unknown. This study used microarray analysis explore long non‐coding ribonucleic acids involved in stress‐induced mineralization. Gain‐ and loss‐of‐function experiments, including Alkaline phosphatase (ALP) activity...
Abstract Cementocytes are terminally differentiated cells embedded in cellular cementum, an important hard tissue covering the apical regions of tooth roots. However, roles cementocytes cementum remain enigmatic. Here, we show that Murine Double Minute 2 (Mdm2), E3 ubiquitin ligase plays vital regulating cell proliferation, apoptosis, and differentiation to influence or organ development, is highly expressed mice. To investigate role cementocyte-expressed Mdm2, Dmp1-Cre;Mdm2flox/flox (Mdm2...
Idiopathic gingival fibromatosis is a rare, benign condition of unknown etiology characterized by extensive overgrowth. This case reports severe skeletal Class Ⅱ adult female patient with idiopathic fibromatosis. The underwent multidisciplinary treatment involving periodontics, orthodontics, and orthognathic surgery, resulting in remarkable crown height elongation, substantial improvements occlusal function aesthetics, stable long-term follow-up outcomes. provides reference for future...
As the β-catenin pathway has been shown to be involved in mechanotransduction, we sought determine if haploinsufficiency would affect skeletal response unloading. It previously that deletion of both alleles bone cells results a fragile skeleton highly susceptible fracture, but one allele using Dmp1-Cre (Ctnnb1+/loxP; Dmp1-Cre, cKO HET) little effect on 2 mo old skeleton. We found under normal housing conditions, trabecular volume was significantly less 5 male HET mice compared controls...
Abstract Intermittent parathyroid hormone (PTH) promotes periodontal repair, but the underlying mechanisms remained unclear. Recent studies found that ephrinB2‐EPHB4 forward signaling mediated anabolic effect of PTH in bone homeostasis. Considering similarities between cementum and bone, we aimed to examine therapeutic on resorbed roots explore role this process. In vivo experiments showed intermittent significantly accelerated regeneration root resorption promoted expression EPHB4 ephrinB2....
Abstract Objectives This study aimed to investigate the effects of intermittent parathyroid hormone (iPTH) on stability orthodontic retention and explore possible regulatory role insulin‐like growth factor‐1 (IGF‐1) in this process. Methods Forty‐eight 6‐week‐old male Wistar rats were adopted study. An relapsing model was established iPTH retention. In vitro, an immortalized mouse cementoblast cell line OCCM‐30 detected by flow cytometry proliferation apoptosis. By application a specific...
Abstract Isoenzyme c of horseradish peroxidase (HRP‐C) is widely used in enzyme immunoassay combined with chemiluminescence (CL) detection. For this application, HRP‐C activity measurement usually based on luminol oxidation the presence hydrogen peroxide (H 2 O ). However, catalysis reaction was enhancer dependent. In study, we demonstrated that Jatropha curcas (JcGP1) showed high efficiency catalyzing H . Compared HRP‐C, JcGP1‐induced independent, which made enzyme‐linked immunosorbent...
To date, therapeutic approaches for cementum regeneration are limited and outcomes remain unpredictable. A significant barrier to improve therapies is that the cementocyte its intracellular signal transduction mechanisms poorly understood. This study aims elucidate regulatory mechanism of Wnt pathway in cementogenesis.The effects canonical signaling were compared vitro using immortalized murine cell line IDG-CM6 osteocyte IDG-SW3 by quantitative real-time polymerase chain reaction, Western...
To investigate the influence of fixed orthodontic treatment on menstrual cycle, including cycle length (MCL) and duration bleeding (DMB), in adult female patients.This was a prospective longitudinal study conducted Chengdu, China. A total 164 women with normal cycles were recruited study, 79 patients undergoing 85 serving as controls. Data MCL, DMB, accompanying symptoms collected over six consecutive each participant. Student's t test, Chi-square Moses extreme reaction repeated measures...