A5100375374- Nutritional Studies and Diet
- Fatty Acid Research and Health
- Diet and metabolism studies
- Nutrition, Genetics, and Disease
- Reproductive Biology and Fertility
- Consumer Attitudes and Food Labeling
- Atrial Fibrillation Management and Outcomes
- Estrogen and related hormone effects
- Diet, Metabolism, and Disease
- Obesity, Physical Activity, Diet
- Evolution and Genetic Dynamics
- Mathematical and Theoretical Epidemiology and Ecology Models
- Liver Disease Diagnosis and Treatment
- Cardiovascular Health and Risk Factors
- Potato Plant Research
- Chemical Synthesis and Analysis
- Sodium Intake and Health
- Mosquito-borne diseases and control
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Evolutionary Game Theory and Cooperation
- Cardiac Arrhythmias and Treatments
- Colorectal Cancer Screening and Detection
- Birth, Development, and Health
Second Affiliated Hospital of Zhejiang University
2021-2025
Zhejiang University
2022-2025
Affiliated Hospital of North Sichuan Medical College
2024
Tianjin Medical University Cancer Institute and Hospital
2018-2024
Affiliated Hospital of Hebei University
2023-2024
Beijing Luhe Hospital Affiliated to Capital Medical University
2024
Jilin Academy of Agricultural Sciences
2010-2024
Institute of Animal Sciences
2018-2024
Shanghai First Maternity and Infant Hospital
2024
Capital Medical University
2008-2023
OBJECTIVE Patients with obesity are at increased risk of exacerbations from viral respiratory infections. However, the association severity coronavirus disease 2019 (COVID-19) is unclear. We examined this using data only referral hospital in Shenzhen, China. RESEARCH DESIGN AND METHODS A total 383 consecutively hospitalized patients COVID-19 admitted 11 January 2020 to 16 February and followed until 26 March Third People’s Hospital Shenzhen were included. Underweight was defined as a BMI...
Abstract Background Eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) have been suggested to prevent the development of metabolic disorders. However, their individual role in treating hyperglycemia mechanism action regarding gut microbiome metabolome context diabetes remain unclear. Results Supplementation DHA EPA attenuated insulin resistance without changing body weight db/db mice while ameliorative effect appeared be more pronounced for EPA. DHA/EPA supplementation reduced abundance...
Western dietary patterns have been unfavorably linked with mental health. However, the long-term effects of habitual fried food consumption on anxiety and depression underlying mechanisms remain unclear. Our population-based study 140,728 people revealed that frequent consumption, especially potato is strongly associated 12% 7% higher risk depression, respectively. The associations were more pronounced among male younger consumers. Consistently, exposure to acrylamide, a representative...
Reported rates of oral anticoagulation (OAC) use have been low among Chinese patients with atrial fibrillation (AF). With improved awareness, changing guidelines, this situation may be over time. We aimed to explore the current status and time trends OAC in Beijing.We used data set from Atrial Fibrillation Registry (CAFR), a prospective, multicenter, hospital-based registry study involving 20 tertiary 12 nontertiary hospitals Beijing. A total 11 496 AF were enrolled 2011 2014.Seven thousand...
Maternal diabetes has been demonstrated to adversely affect oocyte quality in mouse oocytes. However, the potential molecular mechanisms are poorly understood. Here, we established a type I diabetic model and detected increased reactive oxygen species (ROS) levels decreased Sirt3 expression oocytes from mice. Furthermore, found that forced of significantly attenuates such an excessive production ROS. The acetylation status lysine 68 superoxide dismutase (SOD2K68) is dependent on In line with...
The European Society for Clinical Nutrition and Metabolism (ESPEN) guidelines recommend the Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT) to identify malnutrition risk in patients with liver disease. However, little is known about application of RFH-NPT screen China, where primarily suffer from hepatitis virus-related cirrhosis. A total 155 cirrhosis without cancer or uncontrolled co-morbid illness were enrolled this prospective study. We administered Nutritional Risk Screening...
OBJECTIVE To assess the interactions between diet quality and genetic predisposition to incident type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS Between 2006 2010, 357,419 participants with complete dietary data from UK Biobank were enrolled prospectively followed up 2017. The risk score (GRS) was calculated on basis of 424 variants associated T2D risk, a higher GRS indicates T2D. adherence healthy assessed by comprising 10 important components, representing overall quality. RESULTS There...
The study aims to develop novel clinical immunohistochemical biomarkers for distinguishing small hepatocellular carcinoma (sHCC) from dysplastic nodules (DN). iTRAQ–2DLC–ESI–MS/MS technique was used screen between precancerous lesions (liver cirrhosis and DN) sHCC. A total of 1951 proteins were quantified, including 52 upregulated in sHCC 95 downregulated by at least 1.25- or 0.8-fold p < 0.05. selected biomarker candidates further verified using Western blotting immunohistochemistry....
To assess the relationship of circulating fatty acids (FA) with risk type 2 diabetes (T2D) and potential interactions genetic risk.A total 95,854 participants complete data on plasma FA from UK Biobank were enrolled between 2006 2010 followed up to end 2020. Plasma concentrations saturated (SFA), monounsaturated (MUFA), polyunsaturated (PUFA) analyzed by a high-throughput nuclear magnetic resonance-based biomarker profiling platform. The scores (GRS) calculated basis 424 variants associated...
The role of fatty acids (FAs) in primary prevention coronary artery disease (CAD) is highly debated, and the modification effect by genetic risk profiles remains unclear. Here, we report prospective associations circulating FAs predisposition with CAD development 101,367 U.K. Biobank participants. A total 3719 cases occurred during a mean follow-up 11.5 years. Plasma monounsaturated (MUFAs) were positively associated CAD, whereas was significantly lower higher n-3 polyunsaturated (PUFAs)...
The efficacy of many coronavirus disease 2019 (COVID-19) vaccines has been shown to decrease varying extents against new severe acute respiratory syndrome 2 variants, which are responsible for the continuing COVID-19 pandemic. Combining intramuscular and intranasal vaccination routes is a promising approach achieving more potent immune responses. We evaluated immunogenicity prime-boost protocols with chimpanzee adenovirus serotype 68 vector-based vaccine, ChAdTS-S, administered via both in...
The role of plant-based diets in preventing premature death among patients with cardiovascular disease (CVD) has remained unknown. We aim to explore the association dietary patterns all-cause and cause-specific mortality CVD. A total 10 824 participants CVD at baseline were followed up UK Biobank. constructed three types diet indexes [an overall index (PDI), a healthful PDI (hPDI), an unhealthful (uPDI)] by assigning different weights various food groups from web-based 24 h recall...
Background: Cardiovascular disease (CVD) is a leading cause of death in China. Fried foods are risk factor for increasing CVD and their consumption China rapidly rising. Evaluation the impact fried on burden has important implications future public health policy making. This study aimed to evaluate burden. Methods: We estimated temporal trends food from 1997 2011 using data Health Nutrition Survey. events attributed comparative assessment methods. also projected related 2031. Results:...
Docosahexaenoic acid (DHA) and eicosapentaenoic (EPA) have been proposed to benefit cardiometabolic health. However, the relationship between intake of DHA EPA type 2 diabetes (T2D) risk remains equivocal, effects on skeletal muscle, primary organ for glucose metabolism, merit further investigation. Here, we show that habitual fish oil supplementation was associated with a 9% lower T2D significantly interacted variants at GLUT4 in prospective cohort 48,358 people prediabetes. Muscular...
Background Sarcopenia, physical activity (PA), and sedentary behavior are associated with metabolic dysfunction-associated steatotic liver disease (MASLD). The study aimed to evaluate the effects of sarcopenia PA on presence severity MASLD. Methods This cross-sectional analyzed data from 2017-2018 National Health Nutrition Examination Survey (NHANES). Hepatic steatosis fibrosis were assessed by vibration-controlled transient elastography (VCTE). Sarcopenia was defined based Foundation for...