A5101516732- Insect and Pesticide Research
- Plant and animal studies
- Insect and Arachnid Ecology and Behavior
- Bee Products Chemical Analysis
- Fatty Acid Research and Health
- Insect-Plant Interactions and Control
- Nutritional Studies and Diet
- Autophagy in Disease and Therapy
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Nutrition, Genetics, and Disease
- Endoplasmic Reticulum Stress and Disease
- Anorectal Disease Treatments and Outcomes
- Vitamin K Research Studies
- Insect symbiosis and bacterial influences
- Pharmaceutical and Antibiotic Environmental Impacts
- Sunflower and Safflower Cultivation
- Immune cells in cancer
- Meat and Animal Product Quality
- melanin and skin pigmentation
- Flavonoids in Medical Research
- Phytochemical and Pharmacological Studies
- Melanoma and MAPK Pathways
- Metabolomics and Mass Spectrometry Studies
- Diverticular Disease and Complications
Heilongjiang Provincial Academy of Agricultural Sciences
2025
Zhejiang University
2017-2024
Chengdu University of Traditional Chinese Medicine
2023
Sichuan University
2020-2023
First Affiliated Hospital Zhejiang University
2023
Dian Diagnostics (China)
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Xiangya Hospital Central South University
2022
Central South University
2022
State Key Laboratory of Oral Diseases
2020
Abstract Background Eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) have been suggested to prevent the development of metabolic disorders. However, their individual role in treating hyperglycemia mechanism action regarding gut microbiome metabolome context diabetes remain unclear. Results Supplementation DHA EPA attenuated insulin resistance without changing body weight db/db mice while ameliorative effect appeared be more pronounced for EPA. DHA/EPA supplementation reduced abundance...
Summary There is growing number of studies demonstrating a close relationship between insect gut microbiota and insecticide resistance. However, the contribution honey bee to host detoxification ability has yet be investigated. In order address this question, we compared expression cytochrome P450s (P450s) genes deficient (GD) workers conventional community (CV) mortality rates pesticide residue levels GD CV treated with thiacloprid or tau ‐fluvalinate. Our results showed that promotes P450...
OBJECTIVE To assess the interactions between diet quality and genetic predisposition to incident type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS Between 2006 2010, 357,419 participants with complete dietary data from UK Biobank were enrolled prospectively followed up 2017. The risk score (GRS) was calculated on basis of 424 variants associated T2D risk, a higher GRS indicates T2D. adherence healthy assessed by comprising 10 important components, representing overall quality. RESULTS There...
Royal jelly, a honey bee secretion, plays critical role in caste determination bees because it serves as the source of nutrition for young larvae destined to become queens. It is also fed adult jelly possesses numerous functional properties and thus has been used medication, health food, cosmetic many countries. In this paper, we first introduce traditional method producing royal by artificial grafting newly developed that does not require larvae. We describe protocols storage freeze-drying...
Abstract Secretions from mandibular glands (MGs) have important caste-specific functions that are associated with the social evolution of honey bees. To gain insights into molecular architecture underlying these caste differences, we compared gene expression patterns MGs queens, queenright workers (WQRs) and queenless (WQLs) using high-throughput RNA-sequencing technology. In total, identified 46 candidate genes biosynthesis fatty acid pheromones in MG, including members cytochrome P450...
To assess the relationship of circulating fatty acids (FA) with risk type 2 diabetes (T2D) and potential interactions genetic risk.A total 95,854 participants complete data on plasma FA from UK Biobank were enrolled between 2006 2010 followed up to end 2020. Plasma concentrations saturated (SFA), monounsaturated (MUFA), polyunsaturated (PUFA) analyzed by a high-throughput nuclear magnetic resonance-based biomarker profiling platform. The scores (GRS) calculated basis 424 variants associated...
Gut microbial communities play vital roles in the modulation of many insects' immunity, including Apis mellifera . However, little is known about interaction cerana gut bacteria and A. immune system. Here this study, we conducted a comparison between germ-free microbiota deficient (GD) workers conventional community (CV) workers, to reveal possible impact on expression antimicrobial peptides regulate pathways. We also test whether can strengthen host resistance Nosema ceranae find that...
Abstract It is a widespread practice in China to keep colonies of both the western honey bee, Apis mellifera , and eastern cerana close proximity. However, this increases opportunities for spillover parasites pathogens between two host bee species, impacting spatial temporal patterns occurrence prevalence viruses that adversely affect health. We conducted 1‐year large‐scale survey assess current status viral infection A. China. Our study focused on multiple aspects infections bees, including...
The role of fatty acids (FAs) in primary prevention coronary artery disease (CAD) is highly debated, and the modification effect by genetic risk profiles remains unclear. Here, we report prospective associations circulating FAs predisposition with CAD development 101,367 U.K. Biobank participants. A total 3719 cases occurred during a mean follow-up 11.5 years. Plasma monounsaturated (MUFAs) were positively associated CAD, whereas was significantly lower higher n-3 polyunsaturated (PUFAs)...
Gut microbial community plays an important role in the regulation of insect health. Antibiotic treatment is powerful to fight bacterial infections, while it also causes collateral damage gut microbiome, which may have long-lasting consequences for host However, current studies on honey bees mainly focus impact direct exposure antibiotics individual bees, and little known about social transmission antibiotic-induced disorder bee colonies. In order provide insight into potential pass-on effect...
ABSTRACT Sea‐buckthorn leaves contain various active components, and research, development, utilization of sea‐buckthorn have broad application prospects in the fields food, medicine, feed. The comprehensive quality different germplasm resources was evaluated by determining 17 major nutrients, such as flavone composition, polysaccharides, total flavonoids, polyphenols, so on 26 varieties sea buckthorn leaves, then factor analysis, principal component cluster analysis. results showed that...
Sonodynamic therapy (SDT) is an emerging tumor-inhibiting method that has gained attention in cancer the last several years. Although autophagy been observed SDT-treated cells, its role and mechanism of action remain unclear. This study aimed to investigate effects low-frequency ultrasound on drug-resistance paclitaxel (PTX)-resistant PC-3 cells via endoplasmic reticulum stress (ERs)-mediated PI3K/AT/mTOR signaling pathway.CCK-8 assay was conducted select appropriate exposure time for...
Melanoma is a malignant tumor that begins in the melanocyte and has highest mortality rate among all cutaneous tumors. Chinese propolis (CP) been shown to have potent antitumor effect against various cancers. In this study, we uncovered combined effects of antiproliferation anti-inflammation CP on suppressing progression human melanoma cell line A375. We evaluated alterations protein expression after treatment by Western blot. After treatment, A375 cells underwent intrinsic apoptosis cycle...
The increasing incidence of obesity poses a great threat to public health worldwide. Recent reports also indicate the relevance in metabolic diseases. Chinese propolis (CP), as well-studied natural nutraceutical, has shown beneficial effect on alleviating diabetes mellitus. However, few studies have investigated CP weight management and energy balance. We examined effects dietary high-fat diet-fed female male mice determined whether alters gut microbiota. In this study, supplementation...
The functional relevance of intra-species diversity in natural microbial communities remains largely unexplored. guts two closely related honey bee species, Apis cerana and A. mellifera, are colonised by a similar set core bacterial species composed host-specific strains, thereby providing good model for an study. We aim to assess the mellifera gut microbiota. Honey workers were collected from four regions China. Their microbiomes investigated shotgun metagenomic sequencing, compositions...
Antibiotics are frequently employed to control bacterial diseases in honeybees, but their broad-spectrum action can disrupt the delicate balance of gut microbiome, leading dysbiosis. This imbalance microbiota honeybees adversely affects physiological health and weakens resistance pathogens, including viruses that significantly threaten honeybee health. In this study, we investigated whether tetracycline-induced microbiome dysbiosis promotes replication Israeli acute paralysis virus (IAPV), a...
Melanoma, which features high metastasis and lethality, is one of the toughest tumors to treat. Chrysin, rich in various plants, has shown a great inhibitory effect on melanoma proliferation. Here, we evaluated suppressive chrysin vivo vitro. In vitro, effectively inhibited ankios resistance from 5 μM cell migration, invasion 10 μM, tube formation capacity cells 20 μM. We discovered that interfered with mesenchymal–epithelial transition via regulating FOXM1/β-catenin signaling, as expression...
In Asia, honey is mainly produced by Apis mellifera and cerana. However, the price of A. cerana usually much higher than honey. Seeing considerable profits, some dishonest companies beekeepers mislabel as or incorporate into present study, we developed methods to discriminate from based on MRJP2 (major royal jelly protein 2) gene. Two pairs species-specific primers were designed. The amplification products 212 560 bp, respectively. As little one percent incorporation in mixture can be...