A5108672166- Transcranial Magnetic Stimulation Studies
- Stroke Rehabilitation and Recovery
- Neuroscience and Neuropharmacology Research
- Tracheal and airway disorders
- Animal Disease Management and Epidemiology
- Viral Infections and Immunology Research
- EEG and Brain-Computer Interfaces
- Viral Infections and Vectors
- COVID-19 epidemiological studies
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Hepatitis B Virus Studies
- Atrial Fibrillation Management and Outcomes
- Airway Management and Intubation Techniques
- Myasthenia Gravis and Thymoma
- Viral Infections and Outbreaks Research
- Viral gastroenteritis research and epidemiology
- Neurogenesis and neuroplasticity mechanisms
- Liver Disease Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Herpesvirus Infections and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Botulinum Toxin and Related Neurological Disorders
- Cardiac electrophysiology and arrhythmias
- Vascular Malformations and Hemangiomas
Huashan Hospital
2018-2025
Fudan University
2017-2025
Zhejiang University
2014-2025
First Affiliated Hospital Zhejiang University
2012-2025
Ministry of Education of the People's Republic of China
2020-2022
Stomatology Hospital
2022
Guangzhou University of Chinese Medicine
2022
Chinese People's Liberation Army
2021
Jiangxi Provincial People's Hospital
2020-2021
Nanchang University
2020-2021
Abstract Parthanatos is a new form of programmed cell death. It has been recognized to be critical in cerebral ischemia–reperfusion injury, and reactive oxygen species (ROS) can induce parthanatos. Recent studies found that propofol, widely used intravenous anesthetic agent, an inhibitory effect on ROS neuroprotective many neurological diseases. However, the functional roles mechanisms propofol parthanatos remain unclear. Here, we discovered ROS–ER–calcium–mitochondria signal pathway...
For decades, scientists have explored the patterns of neural network remodeling that occur after a stroke. Several studies shown both motor cortexes (MCs) undergo crucial cerebral ischemia. However, mechanism by which corticofugal fibers are remodeled is not well understood. Therefore, this study was aimed at investigating changes in bilateral red nucleus (RN) and MC-RN projections during recovery from large-area stroke rat model with or without constraint-induced movement therapy (CIMT). A...
To determine the baseline hepatitis B surface antigen (HBsAg) levels during different phases of chronic (CHB) patients in China.Six hundred and twenty-three virus or un-infected not receiving antiviral therapy were analyzed a cross-sectional study. The CHB classified into five phases: immune-tolerant (IT, n = 108), immune-clearance (IC, 161), e negative (ENH, 149), low-replicative (LR, 135), liver cirrhosis (LC, 70). HBsAg was quantified (Abbott ARCHITECT assay) correlated with (HBV) DNA,...
ABSTRACT Background Airway management during the perioperative period is a vital component of care. However, there lack consensus on selection medications, timing administration, and airway complications. This aimed to promote more rational standardized application medications. Methods Clinical medical pharmaceutical experts were invited participate in this study using modified Delphi method. Participants completed two rounds online surveys, with second round based responses from first...
// Xuechao Wan 1, * , Zhe Kong Kaili Chu 1 Chuanyou Yi Jian Hu Rui Qin Chen Zhao Fangqiu Fu Hai Wu Yao Li and Yan Huang State Key Laboratory of Genetic Engineering, Shanghai Engineering Research Center Industrial Microorganisms, School Life Sciences, Fudan University, 200433, PR China These authors have contributed equally to this work Correspondence to: Huang, email: huangyan@fudan.edu.cn Keywords: PTCH1-3'UTR; metastasis; miR-101-3p; WGCNA; non-small cell lung cancer Received: May 04, 2017...
Modified constraint-induced movement therapy is an effective treatment for neurological and motor impairments in patients with stroke by increasing the use of their affected limb limiting contralateral limb. However, molecular mechanism underlying its efficacy remains unclear. In this study, a middle cerebral artery occlusion (MCAO) rat model was produced suture method. Rats received modified 1 hour day 14 consecutive days, starting from 7th after occlusion. Day lasted 10 minutes at 2 r/min,...
Constraint-induced movement therapy (CIMT) can promote the recovery of motor function in injured upper limbs following stroke, which may be associated with upregulation α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) at synapses ipsilateral sensorimotor cortex our previous study. However, AMPAR distribution is tightly regulated, and only AMPARs on postsynaptic membrane mediate synaptic transmission. We speculated that remodeling induced by movement-associated activity...
Stroke often results in long-term and severe limb dysfunction for a majority of patients, significantly limiting their activities social participation. Constraint-induced movement therapy (CIMT) is rehabilitation approach aimed explicitly at enhancing upper motor function following stroke. However, the precise mechanism remains unknown. This study explores how CIMT may alleviate forelimb paralysis ischemic mice, potentially through structural functional remodeling brain regions beyond...
The prevention of the COVID-19 pandemic is highly complicated by prevalence asymptomatic and recurrent infection. Many previous immunological studies have focused on symptomatic convalescent patients, while immune responses in patients re-detectable positive cases remain unclear. Here we comprehensively analyzed peripheral T-cell receptor (TCR) repertoire 54 different courses, including asymptomatic, symptomatic, convalescent, cases. We identified a set V-J gene combinations characterizing...
Abstract Purpose To compare the morphological and biomechanical properties of normal cornea keratoconus at different stages. Methods A total 408 patients (517 eyes) with were included in this study. According to Topographic Keratoconus (TKC) grading method, was divided into stage I (TKC = 1, 130 eyes), II 1–2, 2, 164 III 2–3, 3, 125 IV 3–4, 4, 98 eyes). 158 subjects (158 recruited as group. The corneal parameters obtained Scheimpflug tomography (Pentacam) visualization technology (Corvis...
Purpose In this study, we investigated the effects of mirror therapy (MT) combined with contralaterally controlled functional electrical stimulation (CCFES) on upper limb motor function, activities daily life, and corticospinal excitability in post-stroke patients.Methods Sixty patients were randomly divided into four groups: CCFES, MT, MT control. All underwent routine rehabilitation. Those control groups received rehabilitation alone, respectively. Upper living, evaluated before after a...
There is no consensus about whether relatively large mediastinal tumors (≥ 5.0 cm) are suitable for video-assisted thoracoscopic surgery (VATS). Therefore, this study aimed to compare the efficacy and safety of intercostal approach VATS large-sized anterior (5.0–10.0 with invasion surrounding tissues organs. A total 129 patients who received in our hospital between January 2018 July 2022 were consecutively enrolled. Patients divided into 2 groups based on tumor diameter: Group (tumor size...
Objective: Acute gastric lesions are commonly seen in critically ill patients the intensive care unit and can result significant upper gastrointestinal bleeding. However, signaling mechanisms that regulate this severe disease still unclear. In study, we explored involvement of gastrokine 2 (GKN2) development acute mice. Approach: We measured degree injury using water immersion restraint stress mouse model. Inflammatory cells factors were analyzed after lesion induction. The luciferase...
Based on sequence variation in the N-terminus of UL55 gene, which encodes glycoprotein B (gB), human cytomegalovirus (CMV) can be classified into four gBn genotypes. We assessed distribution CMV genotypes and correlation between DNA (detected by real-time PCR) CMV-positive pp65 cells (identified immunohistochemical staining) a cohort hematopoietic stem cell transplant patients. The gB was as follows: gBn1, 60% patients; gBn2, 13.3%; mixed gBn1 gBn3 infection, 26.7%; gBn4 other infections,...