A5090176047- Stroke Rehabilitation and Recovery
- Transcranial Magnetic Stimulation Studies
- Botulinum Toxin and Related Neurological Disorders
- EEG and Brain-Computer Interfaces
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Cerebral Palsy and Movement Disorders
- Acute Ischemic Stroke Management
- Neuroscience and Neuropharmacology Research
- Muscle activation and electromyography studies
- Neurological Disorders and Treatments
- Angiogenesis and VEGF in Cancer
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neural Engineering
- Traumatic Brain Injury and Neurovascular Disturbances
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Spinal Cord Injury Research
- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- S100 Proteins and Annexins
- MicroRNA in disease regulation
- Intracerebral and Subarachnoid Hemorrhage Research
- Spatial Neglect and Hemispheric Dysfunction
- Acupuncture Treatment Research Studies
Beijing Normal University
2025
Huashan Hospital
2016-2025
Fudan University
2016-2025
Bristol-Myers Squibb (United States)
2025
Predictive Science (United States)
2025
Minzu University of China
2024
Chongqing Medical University
2024
Children's Hospital of Chongqing Medical University
2024
Tongji University
2023
Center Point
2022
Early exercise after stroke promoted angiogenesis and increased microvessles density. However, whether these newly formatted vessels indeed give rise to functional vascular improve the cerebral blood flow (CBF) in impaired brain region is still unclear. The present study aimed determine effect of early on CBF ischemic region.Adult male Sprague Dawley rats were subjected 90 min middle artery occlusion(MCAO)and randomly divided into non-exercised control group 24 h later. Two weeks later, was...
Exosomes derived from the cerebral endothelial cells play essential roles in protecting neurons hypoxia injury, but little is known regarding biological effects and mechanisms of exosomes on brain plasticity. In this study, were isolated rodent (bEnd.3 cells) by ultracentrifugation, either cell-derived (EC-Exo) or PBS was injected intraventricularly 2 h after middle artery occlusion/reperfusion (MCAO/R) model surgery Exo group control group, respectively. Sham rats received same surgical not...
Objective: The superiority of risperidone long-acting injection (RLAI) over oral typical and atypical antipsychotics demonstrated in previous studies may be related to the improved drug compliance. aim 12-week randomized, single-blind study was test whether RLAI remained among hospitalized patients that compliance could optimally controlled. Methods: Fifty stable schizophrenic patients, who had maintained on for more than 3 months, were randomized group. Finally 49 (98 %) completed study, no...
Summary Aims Remote ischemic conditionings, such as pre‐ and per‐conditioning, are known to provide cardioprotection in animal models of ischemia. However, little is about the neuroprotection effect postconditioning after cerebral In this study, we aim evaluate motor function rescuing remote limb ( RIP ostC) a rat model acute stroke. Methods Left middle artery occlusion MCAO ) was performed generate stroke, followed by daily ostC treatment for maximum 21 days. The assessed with foot fault...
BACKGROUND: There is limited research on the Minimal Important Change (MIC) of Chinese Western Aphasia Battery (WAB). Since an MIC for WAB has yet to be established, clinical implications data using remain unclear.AIM: This study was establish Quotient (AQ) WAB.DESIGN: The a prospective, longitudinal study.SETTING: rehabilitation department Class A tertiary hospital.POPULATION: One hundred six patients with aphasia after stroke were included and analyzed in study.METHODS: Patients evaluated...
Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape across multiple cancer types achieving durable responses for a significant number of patients. Despite their success, many patients still fail to respond ICIs or develop resistance soon after treatment. We sought identify early features associated with ICI outcome. leveraged MC38 syngeneic tumor model because it has variable response therapy driven by intrinsic heterogeneity. was assessed based on level immune cell...
For decades, scientists have explored the patterns of neural network remodeling that occur after a stroke. Several studies shown both motor cortexes (MCs) undergo crucial cerebral ischemia. However, mechanism by which corticofugal fibers are remodeled is not well understood. Therefore, this study was aimed at investigating changes in bilateral red nucleus (RN) and MC-RN projections during recovery from large-area stroke rat model with or without constraint-induced movement therapy (CIMT). A...
Post-ischemia angiogenesis plays a critical part in the recovery of neural networks. Angiopoietin (Ang) has received much attention recently due to its key role neurovascular remodeling. Exercise is proved contribute normal or injured human skeletal muscle. The therapeutic effect exercise on central after cerebral ischemia, however, not been studied. In present study, we investigated relationship between and expression Ang-1, Ang-2, Tie-2 receptor tyrosine kinase brain using rat model...
Purpose: This study aimed to qualify the improvements of modified constraint-induced movement therapy (m-CIMT) on lower limb stroke patients via assessing centre mass (COM) displacement and basic gait parameters.Methods: A total 22 hemiplegic after with first-time clinical cerebral infarction or haemorrhagic cerebrovascular accident were included in this from May December, 2014. The randomly divided into m-CIMT group conventional (control group), received corresponding training for five...
Background: Constraint-Induced Movement Therapy (CIMT) is one efficient approach to improve functional recovery after ischemic stroke. The underlying molecular mechanism remains unclear. In the current study, we investigated effects of CIMT on angiogenesis and neurogenesis. To start linking our findings mediators, further examined expression Hypoxia-Inducible Factor-1α (HIF-1α), Factor Inhibiting HIF-1 (FIH-1) Vascular Endothelial Growth (VEGF). Methods: Rats were randomly assigned into...