A5101938310- Parasites and Host Interactions
- Helminth infection and control
- Genetics, Aging, and Longevity in Model Organisms
- Toxoplasma gondii Research Studies
- Parasite Biology and Host Interactions
- Parasitic Infections and Diagnostics
- Herpesvirus Infections and Treatments
- Autophagy in Disease and Therapy
- Wildlife Ecology and Conservation
- Cytomegalovirus and herpesvirus research
- Viral Infections and Vectors
- Vasculitis and related conditions
- Vector-borne infectious diseases
- Heat shock proteins research
- Renal Diseases and Glomerulopathies
- DNA Repair Mechanisms
- Fish Ecology and Management Studies
- Species Distribution and Climate Change
- Phytochemicals and Antioxidant Activities
- CRISPR and Genetic Engineering
- Coccidia and coccidiosis research
- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- Reproductive biology and impacts on aquatic species
- Microbial infections and disease research
Zhejiang University
2016-2025
Sichuan Agricultural University
2024
Sir Run Run Shaw Hospital
2023
First Affiliated Hospital of Anhui Medical University
2022
Anhui Medical University
2022
Southeast University
2022
Zhongda Hospital Southeast University
2022
Tianjin University of Traditional Chinese Medicine
2022
Chengdu Research Base of Giant Panda Breeding
2020
Northwest A&F University
2020
Goat domestication was critical for agriculture and civilization, but its underlying genetic changes selection regimes remain unclear. Here, we analyze the genomes of worldwide domestic goats, wild caprid species, historical remains, providing evidence an ancient introgression event from a West Caucasian tur-like species to ancestor goats. One introgressed locus with strong signature harbors MUC6 gene, which encodes gastrointestinally secreted mucin. Experiments revealed that nearly fixed...
Cancer chemoprevention involves the application of natural or synthetic compounds to reduce risk cancer development. One most effective strategies for preventing human cancers might involve inducing phase II detoxifying enzymes and antioxidant via dietary compounds. The regulatory regions these inducible genes encode response element (ARE). Nuclear factor-erythroid 2-related factor 2 (Nrf2), as a transcription factor, plays key role in expression ARE-mediated genes. Similarly, Nrf2 performs...
In the clinical intensive care units (ICU), traditional Chinese medicine (TCM) formulation of Xuebijing has been frequently used for treating sepsis. Nevertheless, underlying pharmacological mechanisms remain largely unclear. Caenorhabditis elegans is an important experimental host bacterial infections. Using C. as animal model, we here examined potential treatment against infection and mechanisms. could inhibit reduction tendency lifespan caused by Pseudomonas aeruginosa infection. For...
Parasitic roundworms are remarkable for their ability to manipulate host immune systems and ameliorate inflammatory diseases. Although much is known about the nature of nematode effectors in modulation, little action mode these molecules. Here, we report that a serine protease inhibitor SPI-I8 extracellular vesicles blood-feeding nematodes like Ancylostoma ceylanicum, Haemonchus contortus Nippostrongylus brasiliensis, effectively halts excessive responses vitro vivo. We demonstrate H....
Abstract Background The mitochondrion is proposed as an ideal target organelle for the control of apicomplexan parasites, whose integrity depends on well-controlled protein import, folding, and turnover. ubiquitin-like domain-containing C-terminal domain phosphatase 1 (UBLCP1) was found to be associated with mitochondrial in Toxoplasma gondii . However, little known about roles mechanisms UBLCP1 this parasite. Methods subcellular localization tachyzoites T. determined by indirect...
Autophagy plays an important role in targeting cellular proteins, protein aggregates and organelles for degradation cell survival. dysfunction has been extensively described neurodegenerative conditions linked to misfolding aggregation. However, the of autophagy prion disease process is unclear. Here, we show that when expressed mouse neuroblastoma N2a cells, cytoplasmic PrP (cyPrP) lead endoplasmic reticulum stress (ER stress), activation reticulon 3 (RTN3), impairment ubiquitin-proteasome...
To determine the baseline hepatitis B surface antigen (HBsAg) levels during different phases of chronic (CHB) patients in China.Six hundred and twenty-three virus or un-infected not receiving antiviral therapy were analyzed a cross-sectional study. The CHB classified into five phases: immune-tolerant (IT, n = 108), immune-clearance (IC, 161), e negative (ENH, 149), low-replicative (LR, 135), liver cirrhosis (LC, 70). HBsAg was quantified (Abbott ARCHITECT assay) correlated with (HBV) DNA,...
Parasitic roundworms (nematodes) have lost genes involved in the de novo biosynthesis of haem, but evolved capacity to acquire and utilise exogenous haem from host animals. However, very little is known about processes or mechanisms underlying acquisition utilisation parasites. Here, we reveal that HRG-1 a conserved unique transporter broad range parasitic nematodes socioeconomic importance, which enables uptake via intestinal cells, facilitates cellular through endo-lysosomal system,...
Abstract Membranous nephropathy (MN), an autoimmune disease, can manifest at any age and is among the most common causes of nephrotic syndrome in adults. In 80% cases, specific etiology MN remains unknown, while remaining cases are linked to drug use or underlying conditions like systemic lupus erythematosus, hepatitis B virus, malignancy. Although about one‐third patients may achieve spontaneous complete partial remission with conservative management, another third face elevated risk...
Toxoplasma gondii is an obligate intracellular apicomplexan parasite that infects almost all warm-blooded vertebrates. Heat shock proteins (HSP) regulate key signal transduction events in many organisms, and heat protein 90 (Hsp90) plays important role growth, development, virulence several parasitic protozoa. Here, we discovered increased transcription of the Hsp90 gene under conditions for bradyzoite differentiation, i.e. alkaline vitro, suggesting may be connected with development T....
The characteristics and the pathogenesis of concomitant antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) immunoglobulin G4-related disease (IgG4-RD) have not been elucidated.We included 92 AAV patients with renal biopsy results. Among them, 10 met both IgG4-RD criteria (concomitant group). IgG subclasses myeloperoxidase (MPO)-ANCA in serum tissue were measured complement activation components detected serum.Patients group had elevated IgG4 levels positive MPO-ANCA....
Abstract Background Toxoplasma gondii is an obligate parasite of all warm-blooded animals around the globe. Once infecting a cell, it manipulates host’s DNA damage response that yet to be elucidated. The objectives present study were three-fold: (i) assess damages in T. -infected cells vitro ; (ii) ascertain causes cells; and (iii) investigate activation responses during infection. Methods HeLa, Vero HEK293 infected with at multiplicity infection (MOI) 10:1. Infected analyzed for biomarker...
CREC represents a public health threat worldwide, and its colonization precedes or occurs simultaneously with infection; once the rate increases, infection rises sharply. In our hospital, of remained low, almost all isolates detected were ICU acquired.
Here, we report that the inhibition of PP2A subfamily by okadaic acid results in an accumulation polysaccharides acute infection stage (tachyzoites) Toxoplasma gondii, which is a protozoan global zoonotic importance and model for apicomplexan parasites. The loss catalytic subunit α (ΔPP2Acα) RHΔku80 leads to polysaccharide phenotype base tachyzoites as well residual bodies significantly compromises intracellular growth vitro virulence vivo. A metabolomic analysis revealed accumulated ΔPP2Acα...
The strongylid nematode Haemonchus contortus is a parasite of major concern for modern livestock husbandry because hostile environmental conditions may induce diapause in the early fourth-stage larvae. A new gene Hc-daf-22 was identified which homologue Ce-daf-22 and human SCPx. Genome walking RACE were performed to obtain whole cDNA genomic sequence this gene. Using qRT-PCR with all developmental stages as templates explore transcription level micro-injection applied confirm promoter...
Haemonchus contortus is a common bloodsucking nematode causing widespread economic loss in agriculture. Upon H. infection, series of host responses elicited, especially those related to T lymphocyte immunity. Existing studies mainly focus on the general immune sheep contortus, lacking investigations at molecular level. The objective this study was obtain systematic transcriptional profiling lymphocytes primary-infected sheep.
Calpain-2 activity promotes aberrant endoplasmic reticulum stress-related apoptosis in hepatocytes
Initial analyses of the abomasal microbiota sheep using 16S rRNA sequencing suggested that probiotic bacteria played a protective role in against H. contortus infection. A recombinant Bacillus subtilis expressing fusion protein CotB-HcGAPDH on its spore’s surface induced strong Th1 immune response murine model. The same recombinant, upon only one oral application, protected infection by reducing egg shedding and decreasing adult worm loads parasite increasing body weight gain infected sheep....
Abstract Background Haemonchus contortus , a blood-feeding parasite, is constantly surrounded by large quantities of heme released from the catabolism host red blood cells. To cope with toxicity free heme, H. needs to uptake and detoxify process believed be paramount for parasite survival. Methods A heme-responsive gene Hc-hrg-2 was identified which homologue Ce-hrg-2. The transcriptional levels in all developmental stages ability were analyzed qRT-PCR. Immunofluorescence analysis cell...