A5101751628- Immune Cell Function and Interaction
- Ovarian cancer diagnosis and treatment
- Cancer Immunotherapy and Biomarkers
- IL-33, ST2, and ILC Pathways
- Ferroptosis and cancer prognosis
- Skin Protection and Aging
- Reconstructive Facial Surgery Techniques
- Reconstructive Surgery and Microvascular Techniques
- Autophagy in Disease and Therapy
- Eosinophilic Esophagitis
- Optical Coherence Tomography Applications
- Esophageal Cancer Research and Treatment
- Immune cells in cancer
- Coronary Interventions and Diagnostics
- Reproductive Biology and Fertility
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Cancer Genomics and Diagnostics
- Genomics, phytochemicals, and oxidative stress
- Facial Nerve Paralysis Treatment and Research
- Photoacoustic and Ultrasonic Imaging
- Inflammatory Biomarkers in Disease Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Retinoids in leukemia and cellular processes
- Cancer, Lipids, and Metabolism
Ruijin Hospital
2025
Shanghai Jiao Tong University
2025
Huazhong University of Science and Technology
2010-2025
Central Hospital of Wuhan
2014-2025
Shandong First Medical University
2016-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
Shandong Provincial Hospital
2017-2024
Shandong University
2017-2024
First Hospital of Jilin University
2015-2024
Jilin University
2015-2024
Ferroptosis is a form of regulated cell death that may facilitate the selective elimination tumor cells. The suppressor p53 (TP53) has been demonstrated to promote ferroptosis via transcription-dependent mechanism. Here, we show TP53 limits erastin-induced by blocking dipeptidyl-peptidase-4 (DPP4) activity in transcription-independent manner. Loss prevents nuclear accumulation DPP4 and thus facilitates plasma-membrane-associated DPP4-dependent lipid peroxidation, which finally results...
Abstract Ferroptosis is a form of regulated cell death driven by oxidative injury promoting lipid peroxidation, although detailed molecular regulators are largely unknown. Here, we show that heatshock 70-kDa protein 5 (HSPA5) negatively regulates ferroptosis in human pancreatic ductal adenocarcinoma (PDAC) cells. Mechanistically, activating transcription factor 4 (ATF4) resulted the induction HSPA5, which turn bound glutathione peroxidase (GPX4) and protected against GPX4 degradation...
Autophagy-dependent cell death may hold the key to understanding molecular basis of ferroptosis.
BackgroundUltrasound is a critical non-invasive test for preoperative diagnosis of ovarian cancer. Deep learning making advances in image-recognition tasks; therefore, we aimed to develop deep convolutional neural network (DCNN) model that automates evaluation ultrasound images and facilitate more accurate cancer than existing methods.MethodsIn this retrospective, multicentre, diagnostic study, collected pelvic from ten hospitals across China between September 2003, May 2019. We included...
We investigated whether permeability transition-mediated release of mitochondrial cytochrome c is a potential therapeutic target for treating acute spinal cord injury (SCI). Based on previous reports, minocycline, second-generation tetracycline, exerts neuroprotection partially by inhibiting and reactive microgliosis. first evaluated at the epicenter after T10 contusive SCI in rats. Cytochrome peaked approximately 4-8 h postinjury. A dose-response study generated safe pharmacological regimen...
MIR34A (microRNA 34a) is a tumor suppressor gene, but how it regulates chemotherapy response and resistance not completely understood. Here, we show that the microRNA MIR34A-dependent high mobility group box 1 (HMGB1) downregulation inhibits autophagy enhances chemotherapy-induced apoptosis in retinoblastoma cell. HMGB1 multifaceted protein with key role autophagy, self-degradative, homeostatic process context-specific cancer. expression through direct MIR34A-binding site within 3′...
Fuchs endothelial corneal dystrophy (FECD) is a leading cause of (CE) degeneration resulting in impaired visual acuity. It genetically complex and age-related disorder, with higher incidence females. In this study, we established nongenetic FECD animal model based on the physiologic outcome CE susceptibility to oxidative stress by demonstrating that exposure ultraviolet A (UVA) recapitulates morphological molecular changes FECD. Targeted irradiation mouse corneas UVA induced reactive oxygen...
Ferroptosis is a form of inflammatory cell death for which key mediators remain obscure. Here, we report that the proteoglycan decorin (DCN) released by cells are dying from ferroptosis and then acts as an alarm signal to trigger innate adaptive immune responses. The early release DCN during active process involves secretory macroautophagy/autophagy lysosomal exocytosis. Once released, extracellular binds receptor advanced glycosylation end-product-specific (AGER) on macrophages production...
Skin is susceptible to premature aging in response ultraviolet (UV) radiation-induced oxidative stress, which can ultimately result aberrant or age-related disorders. Accordingly, strategies that be adopted mitigate stress may contribute protecting skin from induced aging-related damage, thereby offering promising approaches for the treatment of diseases and In this regard, oroxylin A (OA), a natural flavonoid isolated certain plants used traditional Chinese medicine, considered have notable...
Summary Dendritic cells ( DC s), a bridge for innate and adaptive immune responses, play key role in the development of multiple sclerosis MS ) experimental autoimmune encephalomyelitis EAE ), an animal model . Administration tolerogenic s has been used as immunotherapy diseases. Deficiency vitamin D is environmental risk factor In this study, we induced by 1,25‐dihydroxyvitamin 3 transferred VD ‐ s) into mice adoptive transfer. We found that inhibited infiltrations T helper type 1 (Th1)...
Both apoptosis ("self-killing") and autophagy ("self-eating") are evolutionarily conserved processes, their crosstalk influences anticancer drug sensitivity cell death. However, the underlying mechanism remains unclear. Here, we demonstrated that HMGB1 (high mobility group box 1), normally a nuclear protein, is crucial regulator of TNFSF10/TRAIL (tumor necrosis factor [ligand] superfamily, member 10)-induced cancer Activation PARP1 (poly [ADP-ribose] polymerase 1) was required for...
Antibodies targeting the immune checkpoint inhibitor, programmed cell death 1 (PD-1), have provided a breakthrough in treatment of lung cancer.However, function PD-1 natural killer (NK) cells cancer patients remains unclear.Herein, we analyzed expression on NK peripheral blood with and found that level + was significantly higher than healthy individuals.Moreover, these demonstrated weaker ability to secrete interferon-gamma (INF-γ), granzyme B, perforin, exhibited lower CD107a...
HMGB1 is associated with human cancers and an activator of autophagy which mediates chemotherapy resistance. We here show that the mRNA levels are high in leukemia cells it involved progression childhood chronic myeloid (CML). decreases sensitivity K562 to anti-cancer drug induced death through up-regulating pathway, confirmed by observation increase fusion autophagosomes autophagolysosomes. When overexpressing HMGB1, both Beclin-1, VSP34 UVRAG key genes mammalian protein p-Bcl-2 LC3-II...
IFN1@ (interferon, type 1, cluster, also called IFNα) has been extensively studied as a treatment for patients with chronic myeloid leukemia (CML). The mechanism of anticancer activity is complex and not well understood. Here, we demonstrate that autophagy, cellular homeostasis the removal dysfunctional organelles proteins, regulates IFN1@-mediated cell death. activated autophagic machinery in immortalized or primary CML cells. Activation JAK1-STAT1 RELA signaling were required IFN1@-induced...
Breast cancer patients with high proportion of stem cells (BCSCs) have unfavorable clinical outcomes. MicroRNAs (miRNAs) regulate key features BCSCs. We hypothesized that a biology-driven model based on BCSC-associated miRNAs could predict prognosis for the most common subtype, hormone receptor (HR)-positive, HER2-negative breast patients.After screening candidate literature review and pilot study, we built miRNA-based classifier using LASSO Cox regression method in training group (n=202)...
Pattern recognition receptors (PRRs) are germline-encoded host sensors of the innate immune system. Some human cancer cells have been reported to express PRRs. However, nucleic acid in cancers not studied detail. Therefore, we systematically analyzed expression, molecular cascade, and functions TLR3, RIG-I, MDA5, LGP2, cGAS, STING cells. TRIF, MAVS were expressed 22 cell lines. The majority lines responded only RIG-I ligands 5′-ppp-dsRNA, Poly(I:C)-HMW, Poly(I:C)-LMW, and/or Poly(dA:dT), as...