A5100386463- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- RNA Research and Splicing
- Metal complexes synthesis and properties
- MRI in cancer diagnosis
- Peptidase Inhibition and Analysis
- Ovarian cancer diagnosis and treatment
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Traditional Chinese Medicine Studies
- Gallbladder and Bile Duct Disorders
- Advanced X-ray and CT Imaging
- Ferrocene Chemistry and Applications
- Medical Imaging Techniques and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- DNA and Nucleic Acid Chemistry
- Epigenetics and DNA Methylation
- Fatigue and fracture mechanics
- Private Equity and Venture Capital
- Medical Research and Treatments
- Gastric Cancer Management and Outcomes
- High Temperature Alloys and Creep
Zhejiang Provincial People's Hospital
2022-2025
Center For Reconstructive Urethral Surgery
2025
Hangzhou Medical College
2022-2025
Beijing University of Chinese Medicine
2016-2025
Qingdao Municipal Hospital
2024
Qingdao University
2024
Indiana University School of Medicine
2020-2024
Indiana University Bloomington
2020-2024
Xuzhou Medical College
2022-2024
Shanghai University
2021-2024
PTENP1 is a pseudogene of the PTEN tumor suppression gene (TSG). The functions in clear-cell renal cell carcinoma (ccRCC) have not yet been studied. We found that downregulated ccRCC tissues and cells due to methylation. are direct targets miRNA miR21 their expression suppressed by lines. promotes proliferation, migration, invasion vitro, growth metastasis vivo. Overexpression expressing reduces invasion, growth, metastasis, recapitulating phenotypes induced expression. sensitizes these...
BackgroundUltrasound is a critical non-invasive test for preoperative diagnosis of ovarian cancer. Deep learning making advances in image-recognition tasks; therefore, we aimed to develop deep convolutional neural network (DCNN) model that automates evaluation ultrasound images and facilitate more accurate cancer than existing methods.MethodsIn this retrospective, multicentre, diagnostic study, collected pelvic from ten hospitals across China between September 2003, May 2019. We included...
// Wenqian Li 1 , Xiaoxue Zhang Ji Wang Mengchen Canhui Cao Jiahong Tan Ding Ma and Qinglei Gao Cancer Biology Research Center (Key Laboratory of The Ministry Education), Tongji Hospital, Medical College, Huazhong University Science Technology, Wuhan, Hubei 430030, People’s Republic China Correspondence to: Ma, email: dma@tjh.tjmu.edu.cn Gao, qlgao@tjh.tjmu.edu.cn Keywords: ovarian cancer; CAF; exosomes; TGFβ1; epithelial-mesenchymal transition Received: May 09,...
Background Long noncoding RNAs (lncRNAs) are an important class of pervasive genes involved in a variety biological functions. They aberrantly expressed many types cancers. In this study, we described lncRNAs profiles 6 pairs human renal clear cell carcinoma (RCCC) and the corresponding adjacent nontumorous tissues (NT) by microarray. Methodology/Principal Findings With abundant varied probes accounting 33,045 LncRNAs our microarray, number that at certain level could be detected is 17157....
Detection of breast cancer at an early stage is the key for successful treatment and improvement outcome. However limitations mammography are well recognized, especially those women with premenopausal cancer. Novel approaches to screening necessary, in developing world where not feasible. In this study, we examined promoter methylation six genes (SFN, P16, hMLH1, HOXD13, PCDHGB7 RASSF1a) circulating free DNA (cfDNA) extracted from serum. We used a high-throughput assay (MethyLight) examine...
Epigenetics has been known to play a critical role in regulating the malignant phenotype. This study was designed examine expression of DOT1L (histone 3 lysine 79 methyltransferase) and H3K79 methylation normal ovarian tissues tumors explore function its underline mechanisms cancer. The 250 tumor samples 24 assessed by immunohistochemistry. effects on cell proliferation vitro were evaluated using CCK8, colony formation flow cytometry. DOT1L-targeted genes determined chromatin...
Abstract Chemoresistance is a major unmet clinical obstacle in ovarian cancer treatment. Epigenetics plays pivotal role regulating the malignant phenotype, and has potential developing therapeutically valuable targets that improve dismal outcome of this disease. Here we show series transcription factors, including C/EBPβ, GCM1, GATA1, could act as modulators histone methylation tumor cells. Of note, an independent prognostic factor for patients with cancer, mediates important mechanism...
Abstract Chronic inflammatory diseases, such as intervertebral disc degeneration (IVDD), which affect the lives of hundreds millions people, still lack effective and precise treatments. In this study, a novel hydrogel system with many extraordinary properties is developed for gene–cell combination therapy IVDD. Phenylboronic acid‐modified G5 PAMAM (G5‐PBA) first synthesized, therapeutic siRNA silencing expression P65 mixed G5‐PBA (siRNA@G5‐PBA) then embedded into (siRNA@G5‐PBA@Gel) based on...
Abstract Frequent relapse and chemoresistance cause poor outcome in ovarian cancer (OC) stem cells (CSCs) are important contributors. While most studies focus exclusively on CSCs, the role of microenvironment providing optimal conditions to maintain their tumor-initiating potential remains poorly understood. Cancer associated fibroblasts (CAFs) a major constituent OC tumor we show that CAFs CSCs enriched following chemotherapy patient tumors. significantly increase cell resistance...
Downstream analysis of circulating tumor cells (CTCs) has provided new insights into cancer research. In particular, the detection CTCs, followed by regulation and monitoring their intracellular activities, can provide valuable information for comprehensively understanding pathogenesis progression. However, current CTC techniques are rarely capable in situ microenvironments over time. Here, we developed a multifunctional branched nanostraw (BNS)-electroporation platform that could...
Cancer immunotherapy has revolutionized the field of cancer treatment in recent years. However, not all patients receiving exhibit durable responses, and reliable, high-throughput testing platforms are urgently needed to guide personalized immunotherapy. The ability patient-derived tumor organoids recapitulate pivotal features original tissues makes them useful as a preclinical model for research precision medicine. Nevertheless, many challenges exist translation organoid clinical decision...
Abstract The extracellular matrix (ECM) engages in regulatory interactions with cell surface receptors through its constituent proteins and polysaccharides. Therefore, nano‐sized conjugated doxorubicin (DOX) is utilized to produce matrix‐drug conjugates (ECM‐DOX) tailored for targeted delivery cancer cells. ECM‐DOX nanoparticles exhibit rod‐like morphology, boasting a commendable drug loading capacity of 4.58%, coupled acid‐sensitive release characteristics. Notably, enhance the uptake by...
Long non‑coding RNA (lncRNA) H19 and Lin28 protein have been shown to participate in various pathophysiological processes, including cellular proliferation, autophagy epithelial‑mesenchymal transition (EMT). A number of studies investigated lncRNAs, microRNAs mRNAs, their roles the initiation progression cancer, doing so identifying competitive endogenous (ceRNA) networks, H19/let‑7/Lin28 network. However, whether ceRNA network is involved EMT breast cancer (BC) remains unclear. The present...
The <italic>in vitro</italic> cytotoxicity, apoptosis, cellular uptake, cell cycle arrest, ROS, mitochondrial membrane potential, western blot analysis and DNA-binding induced by <bold>Ru1</bold> were investigated.
Abstract Long noncoding RNA NUTM2A‐AS1 has been shown to be dysregulated in non‐small cell lung carcinoma. To date, it is unclear whether plays a role gastric cancer progression. The purpose of this study elucidate the molecular mechanism cancer. mRNA and protein levels were measured by RT‐qPCR western blot methods. Invasion ability was examined transwell assay. Cell viability determined MTT Dual‐luciferase assay, pull down, immunoprecipitation used confirm direct binding between miR‐376a or...
Environmental pollutants are mainly produced by human production and living, pose a serious threat to health. Health risk assessments of environmental needed in order contribute the development reasonable control measures. In comparison two-dimensional (2D) cell culture experimental animals, organoids excellent alternative models for health assessment pollutants. this review, we described application toxicity testing Finally, there was discussion unique advantages challenges as test models....