A5070982004- Nanoplatforms for cancer theranostics
- Heavy metals in environment
- Arsenic contamination and mitigation
- Photochromic and Fluorescence Chemistry
- Synthesis and biological activity
- Photodynamic Therapy Research Studies
- Luminescence Properties of Advanced Materials
- Advanced biosensing and bioanalysis techniques
- Iron oxide chemistry and applications
- Retinal Development and Disorders
- Luminescence and Fluorescent Materials
- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Heat Transfer Mechanisms
- Molecular Sensors and Ion Detection
- Porphyrin and Phthalocyanine Chemistry
- Heat Transfer and Optimization
- Preterm Birth and Chorioamnionitis
- Nanoparticle-Based Drug Delivery
- Heavy Metals in Plants
- RNA Interference and Gene Delivery
- Pregnancy-related medical research
- High-Temperature Coating Behaviors
- Photoreceptor and optogenetics research
- Perovskite Materials and Applications
Third Affiliated Hospital of Sun Yat-sen University
2025
Sun Yat-sen University
2025
Jinan University
2018-2025
Wenzhou University
2025
Hunan Agricultural University
2019-2024
Wenzhou Medical University
2023-2024
Jiangsu Normal University
2023-2024
ShanghaiTech University
2021-2024
First Affiliated Hospital of Wenzhou Medical University
2023-2024
Zhejiang A & F University
2024
BackgroundUltrasound is a critical non-invasive test for preoperative diagnosis of ovarian cancer. Deep learning making advances in image-recognition tasks; therefore, we aimed to develop deep convolutional neural network (DCNN) model that automates evaluation ultrasound images and facilitate more accurate cancer than existing methods.MethodsIn this retrospective, multicentre, diagnostic study, collected pelvic from ten hospitals across China between September 2003, May 2019. We included...
As effective ways to regulate protein levels, targeted degradation technologies have attracted great attention in recent years. Here, we established a novel integrin-facilitated lysosomal (IFLD) strategy degrade extracellular and cell membrane proteins using bifunctional compounds as molecular degraders. By conjugation of target protein-binding ligand with an integrin-recognition ligand, the resulting degrader proved be highly efficient induce internalization subsequent or integrin-...
Two advanced boron dipyrromethene (BODIPY) based photosensitizers have been synthesized and characterized. With a glibenclamide analogous moiety, these compounds can localize in the endoplasmic reticulum (ER) of HeLa human cervical carcinoma cells HepG2 hepatocarcinoma cells. The BODIPY π skeleton is conjugated with two styryl or carbazolylethenyl groups, which substantially red-shift Q-band absorption fluorescence emission impart two-photon (TPA) property to chromophores. TPA cross section...
Hollow mesoporous silica nanoparticles (HMSNs) served as nanocarriers for transporting doxorubicin hydrochloride (DOX) and indocyanine green (ICG) were incorporated into a pH-sensitive targeted drug delivery system (DDS). Boronate ester bonds employed to link HMSNs dopamine-modified hyaluronic acid (DA-HA), which acted both the "gatekeeper" targeting agents (HMSNs-B-HA). Well-dispersed HMSNs-B-HA with diameter of about 170 nm was successfully constructed. The conclusion drawn from in vitro...
Abstract Developing efficient cyan‐green phosphors and ultrathin phosphor‐glass composites (PGCs) with remarkable chemical thermal stability is important for fabricating full‐visible‐spectrum white light‐emitting diodes (LEDs). In this study, a garnet‐structured phosphor, known as Y 3 Sc 2 Ga O 12 :Ce (YSGG:Ce), synthesized, exhibiting an intense excitation peak at 420 nm broad‐emission band centered 507 nm. Theoretical analysis indicates that phonon characteristic energy of 90 meV...
A boron dipyrromethene based photosensitiser substituted with a 1,2,4,5-tetrazine moiety has been prepared of which the photoactivity can be activated upon an inverse-electron-demand Diels-Alder reaction trans-cyclooctene derivatives. By using biotin-conjugated to tag biotin-receptor-positive HeLa cells, this exhibits site-specific activation through cycloaddition, leading high photocytotoxicity.
A novel molecular therapeutic agent was designed and synthesized, which contains three functional components, namely, a zinc(II) phthalocyanine substituted with 2,4-dinitrobenzenesulfonate (DNBS) group as glutathione (GSH)-activated photosensitizer, chemo-prodrug based on combretastatin A-4 (CA4) singlet oxygen-cleavable aminoacrylate linker, biotin moiety tumor-targeting ligand. The conjugate showed preferential uptake toward the biotin-receptor-positive HepG2 cells compared low...
AAN effective sensor: The two-photon turn-on fluorescent probe NHU was synthesized to optically detect tyrosinase activity in vitro and melanoma cells. is composed of a 4-aminophenol moiety naphthylamine unit, both which are connected through urea linkage. Upon exposure tyrosinase, the site gradually oxidized corresponding orthoquinone, ultimately releasing highly product 6-acyl-N-methyl-2-naphthylamine (AAN).