A5080562476- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Mechanisms of cancer metastasis
- Ovarian cancer diagnosis and treatment
- Cancer Research and Treatments
- Cell Adhesion Molecules Research
- Cervical Cancer and HPV Research
- Vitamin K Research Studies
- Reproductive tract infections research
- 3D Printing in Biomedical Research
- Signaling Pathways in Disease
- Peptidase Inhibition and Analysis
- Vitamin C and Antioxidants Research
- Advanced Glycation End Products research
- Tannin, Tannase and Anticancer Activities
- Probiotics and Fermented Foods
- Glycosylation and Glycoproteins Research
- Urinary Tract Infections Management
- Proteoglycans and glycosaminoglycans research
- Epigenetics and DNA Methylation
- Angiogenesis and VEGF in Cancer
- Piperaceae Chemical and Biological Studies
- Bioactive Compounds and Antitumor Agents
- Cellular Mechanics and Interactions
- Chromatography in Natural Products
Indiana University Bloomington
2017-2024
Indiana University School of Medicine
2017-2024
Indianapolis Zoo
2023
Indiana University – Purdue University Indianapolis
2023
Mayo Clinic in Arizona
2023
Mayo Clinic
2023
Massachusetts General Hospital
2023
University of Illinois Chicago, Rockford campus
2016-2020
Indiana University
2018
University School
2018
Abstract Frequent relapse and chemoresistance cause poor outcome in ovarian cancer (OC) stem cells (CSCs) are important contributors. While most studies focus exclusively on CSCs, the role of microenvironment providing optimal conditions to maintain their tumor-initiating potential remains poorly understood. Cancer associated fibroblasts (CAFs) a major constituent OC tumor we show that CAFs CSCs enriched following chemotherapy patient tumors. significantly increase cell resistance...
Dissemination of ovarian cancer cells can lead to inoperable metastatic lesions in the bowel and omentum that cause patient death. Here we show LRRC15, a type-I 15-leucine-rich repeat-containing membrane protein, highly overexpressed metastases compared with matched primary tumors acts as potent promoter omental metastasis. Complementary models demonstrated LRRC15 expression leads inhibition anoikis-induced cell death promotes adhesion invasion through matrices mimic omentum....
Metastatic colonization involves paracrine/juxtacrine interactions with the microenvironment inducing an adaptive response through transcriptional regulation. However, identities of transcription factors (TFs) induced by metastatic in ovarian cancer (OC) and their mechanism action is poorly understood. Using organotypic 3D culture model recapitulating early events metastasis, we identified ETS1 as most upregulated member ETS family TFs metastasizing OC cells they interacted microenvironment....
Apoptosis and autophagy are important processes that control cellular homeostasis have been highlighted as promising targets for novel anticancer drugs. This study aims to investigate the inhibitory effects mechanisms of Neferine (Nef), an alkaloid from lotus seed embryos Nelumbo nucifera (N. nucifera) , a dual inducer apoptosis through reactive oxygen species (ROS) activation in cervical cancer cells. Nef N. extract suppressed cell viability HeLa SiHa cells dose‐dependent manner....
To assess the probiotic nature of Lactobacillus in preventing cervical pathogens by studying effectiveness antimicrobial activity against vaginal pathogens. Lactobacilli were isolated from healthy swabs on selective media and different pathogenic bacteria using media. The strains tested for production hydrogen peroxide compounds along with properties. Of 10 strains, strain 1, 3 6 are high producers rest low producers. Results pH amines tests indicated that increased fishy odour fluids...
The potential role of free radicals and associated oxidative stress has been well documented in the development many diseases. Free are mainly derived from oxygen (reactive species, ROS) nitrogen RNS), under various physicochemical or pathological conditions. Excessive amount eventually attack biomolecules including proteins, lipids DNA, thus results increased damage leads to alter physiological functions cell implicated activation transcription factors triggers a number human diseases...
Abstract Treatment of ovarian cancer is limited by extensive metastasis and yet it remains poorly understood. We have studied the critical step metastatic colonization in context productive interactions with microenvironment a goal identifying key regulators. By combining miRNA expression analysis using an organotypic 3D culture model early that matched primary tumors from 42 patients cancer, we identified miR-4454 as regulator both advanced cancer. was downregulated metastasizing cells...
ABSTRACTThe present study is aimed at the naphthalene degradation with and without biosurfactant produced from Pseudomonas aeruginosa isolated oil-contaminated soil. The was carried out to isolate bacterial strains for also production. were screened their ability degrade by methods of optimum growth rate test production biosurfactants cetyltrimethylammonium bromide, blood agar medium, thin-layer chromatography. focused on effect isolate-1. Two screened, one biodegradation another second...
Yichun Blue Honeysuckle (YBHS) is reported to have a broad range of health benefits including protection against number chronic diseases. The objective our study was determine whether YBHS exhibits antioxidant activity, and if so, how it provides oxidative stress. Eight-week old mice (25 male 25 female) were randomized into five groups (n = 10 per group). extract (at 6.25%, 12.5%, or 25%) administrated via intra-gastric tube at 0.1 mL/10 g body weight once daily for 7 days. On the 8th day,...
The aim of the present study was to evaluate role microbial enzymes in normal and abnormal cervicovaginal fluids cervical dysplasia. infections were evaluated through estimation patients with without cytology like bacterial fungal infections. categorized based on infection caused by organism stages pH, Whiff test, Pap smear tests conducted for swabs standard protocols. Microbial include mucinase, sialidases, proteases are estimated according methods. results cytological smears showed...