A5100340681- Photoacoustic and Ultrasonic Imaging
- Optical Coherence Tomography Applications
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Thermography and Photoacoustic Techniques
- Nanoplatforms for cancer theranostics
- Advanced Fluorescence Microscopy Techniques
- Retinal and Optic Conditions
- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Optical Imaging and Spectroscopy Techniques
- Advanced Fiber Laser Technologies
- Neuroscience and Neural Engineering
- Photonic Crystal and Fiber Optics
- Ultrasound and Hyperthermia Applications
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Advanced Numerical Methods in Computational Mathematics
- Optical Network Technologies
- Digital Imaging for Blood Diseases
- Perovskite Materials and Applications
- Ocular Infections and Treatments
- Phytochemistry and Bioactivity Studies
- Ocular Diseases and Behçet’s Syndrome
Gannan Medical University
2024-2025
Shanghai Jiao Tong University
2010-2024
Peking University
2015-2024
Capital Medical University
2008-2024
Beijing Tongren Hospital
2008-2024
Hospital for Special Surgery
2024
University of Warwick
2024
Cystic Fibrosis Foundation
2023
Medical University of Vienna
2020-2022
Southwest University
2014-2022
A combination treatment strategy that relies on the synergetic effects of different therapeutic approaches has been considered to be an effective method for cancer therapy. Herein, a chemotherapeutic drug (doxorubicin, Dox) and manganese ion (Mn2+) were co-loaded into regenerated silk fibroin-based nanoparticles (NPs), followed by surface conjugation phycocyanin (PC) construct tumor microenvironment-activated nanococktails. The resultant PC-Mn@Dox-NPs showed increased release rates...
Optical coherence tomography (OCT) is a rapidly emerging imaging modality that can non-invasively provide cross-sectional, high-resolution images of tissue morphology in situ and real-time. We previously demonstrated OCT capable visualizing characteristic kidney anatomic structures, including blood vessels, uriniferous tubules, glomeruli, renal capsules on Munich-Wistar rat model. Because the viability donor closely correlated with its tubular morphology, large amount image datasets are...
Introduction T2 mapping can characterize peripheral neuropathy and muscle denervation due to axonal damage. Three-dimensional double echo steady-state (DESS) simultaneously provide 3D qualitative information maps with equivalent spatial resolution. However, insufficient signal-to-noise ratio may bias DESS-T2 values. Deep learning reconstruction (DLR) techniques reduce noise, hence improve quantitation of high-resolution DESS-T2. This study aims (i) evaluate the effect DLR methods on values,...
We developed an improved dual band focus spectral domain optical coherence tomography (SD-OCT) for in vivo 2D/3D imaging of the whole eye segment, including anterior segment and retina.The system featured two OCT channels with different bands centered at 840 nm 1050 nm, which were designed to image retina segments eye, respectively.By combing probe light beams co-axial scanning separating them focusing a combination three dichroic mirrors, we not only minimized loss backscattered from sample...
This study synthesizes a semiconducting polymer (SP) contrast agent named PY-DPP-δ by introducing highly absorptive, bay-shaped Y5 analogue building block with extended conjugation and significant steric hindrance. exhibits substantial absorption in the near-infrared (NIR) window considerable molecular backbone noncoplanarity (with dihedral angle of 12.2°), leading to robust twisted intramolecular charge transfer effect that can potentially boost photoacoustic (PA) signal intensity. The...
A photoacoustic (PA) imaging technique using the second near-infrared (NIR-II) window has attracted more and attention because of its merits deeper penetration depth higher signal-to-noise (S/N) ratio than that first (NIR-I) one. However, design development high-performance PA contrast agents in NIR-II is still a challenge. semiconducting polymer, constructed by asymmetric units, exhibits regiorandom characteristics effectively increase distortion backbone. This degree twist can regulate...
In this work, a novel fiber optic sensor based on Fabry–Pérot interferometry is adopted in an optical coherence photoacoustic microscopy (OC-PAM) system to enable high-resolution vivo imaging. The complete OC-PAM characterized using the for measurement. After characterization, performance of evaluated by imaging zebrafish larvae vivo. With lateral resolution 3.4 μm and axial 3.7 air, subsystem visualizes anatomy larvae. reveals vasculature with 1.9 37.3 μm. As two modalities share same...
The human eyes provide a natural window for noninvasive measurement of the pulse wave velocity (PWV) small arteries. By measuring retinal PWV, stiffness arteries can be assessed, which may better detect early vascular diseases. Therefore, PWV has attracted increasing attention. In this study, jump‐scanning method was proposed using spectral‐domain optical coherence tomography (SD‐OCT). uses phase‐resolved Doppler OCT to obtain shapes. To realize measurement, extracts transit time from an...
A vascular tree extraction algorithm is proposed to automatically extract independent and complete trees from both background other crossed for photoacoustic microscopy (PAM) imaging. Extracted parameters include centerline, diameters, boundaries three‐dimensional (3‐D) direction along the tree. Based on concept of blood vessel tracking, extracts by utilizing a ray casting framework realize functions which includes estimation, branching detection crossover point detection. An...
We analyze the influence of intrinsic polarization alignment on image quality and axial resolution employing a broadband 840 nm light source with an optical bandwidth 160 output power 12 mW tailored for spectral-domain coherence microscopy (SD-OCM) applications. Three superluminescent diodes (SLEDs) are integrated into 14-pin butterfly module using free-space micro-optical bench architecture, maintaining constant state across full spectral output. demonstrate superior imaging performance in...
Renewable energy is becoming more important all over the world, and wind most role in renewable right now. Many countries are producing building turbines, turbine size larger. The larger a is, expensive it will be. However, turbines fail when overspeeding. So we need control algorithms to protect develop power output efficiency. study concerns implementation of adaptive on Horizontal Axis Wind Turbine (HAWT). This paper focuses Transition Region between 2 3. For 2, Adaptive Disturbance...
To evaluate the toxic effects of two triamcinolone acetonide (TA) vehicles on rabbit retina at different volumes.Vehicle A and B were prepared from TA injections by centrifugation. Thirty-six New Zealand white rabbits intravitreally injected with vehicle A, B, or balanced saline solution 0.1 mL 0.2 respectively. The eyes examined indirect ophthalmoscope, light microscope, transmission electron microscope up to week 8 postinjection.Eyes appeared normal under but showed disorganization in...
Quantitative analysis of optical clearing effects (OCE) induced by hyperosmotic agents is very important to tissue applications in biomedical diagnostic imaging and therapeutics. This study aims at investigating the effect glycerol concentration on laser-scanning optical-resolution photoacoustic microscopy (LSOR-PAM) contrast light penetration depth. The (PA) signal amplitude changes are evaluated as a function glycerol. results reveal that PA amplitudes enhanced with increasing, also show...
Abstract Purpose To compare the morphological and biomechanical properties of normal cornea keratoconus at different stages. Methods A total 408 patients (517 eyes) with were included in this study. According to Topographic Keratoconus (TKC) grading method, was divided into stage I (TKC = 1, 130 eyes), II 1–2, 2, 164 III 2–3, 3, 125 IV 3–4, 4, 98 eyes). 158 subjects (158 recruited as group. The corneal parameters obtained Scheimpflug tomography (Pentacam) visualization technology (Corvis...
Gastrointestinal (GI) endoscopy is a common medical diagnostic procedure used for esophageal cancer detection. Current emerging capsule optoacoustic endoscopes, however, suffer from low pulse repetition rates and slow scanning units limit attainable imaging frame rates. Consequently, motion artifacts result in inaccurate spatial mapping misinterpretation of data. To overcome these limitations, we report 360º, 50 Hz rate, distal endoscope. The translational capability the instrument human GI...
We developed a fast ultrahigh resolution optical coherence photoacoustic microscopy (FU-OCPAM) system by combining two complementary imaging modes of (OCM) and (PAM) for cellular/subcellular imaging. The used scanning to realize speed provided 1.24 0.59 μm OCM PAM, respectively. imaged the retinal pigment epithelium (RPE) demonstrate subcellular capability FU-OCPAM system. PAM images clearly showed RPE cell morphology reflected properties scattering absorption. A quantitative analysis cells...