A5050886287- Photoacoustic and Ultrasonic Imaging
- Thermography and Photoacoustic Techniques
- Optical Imaging and Spectroscopy Techniques
- Nanoplatforms for cancer theranostics
- Ultrasound and Hyperthermia Applications
- Ultrasound Imaging and Elastography
- Optical measurement and interference techniques
- Advanced X-ray and CT Imaging
- Optical Coherence Tomography Applications
- Surface Roughness and Optical Measurements
- Extracellular vesicles in disease
- Advanced Measurement and Metrology Techniques
- Advanced Fluorescence Microscopy Techniques
- Digital Holography and Microscopy
- Photodynamic Therapy Research Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Near-Field Optical Microscopy
- Venous Thromboembolism Diagnosis and Management
- Atmospheric and Environmental Gas Dynamics
- Advanced Nanomaterials in Catalysis
- Image Processing Techniques and Applications
- Thermal Regulation in Medicine
- Molecular Communication and Nanonetworks
- Ultrasonics and Acoustic Wave Propagation
- Infrared Thermography in Medicine
Iowa State University
2023-2025
Institute of Engineering
2025
Nanyang Technological University
2014-2023
Tarbiat Modares University
2019
City University of Hong Kong
2015
Indian Institute of Science Bangalore
2005-2014
Laboratoire d’Imagerie Biomédicale
2014
Washington University in St. Louis
2008-2011
Optica
2008-2010
Abstract Room temperature liquid metals (LMs) represent a class of emerging multifunctional materials with attractive novel properties. Here, we show that photopolymerized LMs present unique nanoscale capsule structure characterized by high water dispersibility and low toxicity. We also demonstrate the LM nanocapsule generates heat reactive oxygen species under biologically neutral near-infrared (NIR) laser irradiation. Concomitantly, NIR exposure induces transformation in shape, destruction...
Despite its growing promise in cancer treatment, ferrotherapy has low therapeutic efficacy due to compromised Fenton catalytic efficiency tumor milieu. We herein report a hybrid semiconducting nanozyme (HSN) with high photothermal conversion for photoacoustic (PA) imaging-guided second near-infrared ferrotherapy. HSN comprises an amphiphilic polymer as converter, PA emitter and iron-chelating catalyst. Upon photoirradiation, generates heat not only induce cytotoxicity but also enhance...
Photoacoustic (PA) imaging holds great promise for preclinical research and clinical practice. However, most studies rely on the laser wavelength in first near-infrared (NIR) window (NIR-I, 650–950 nm), while few have been exploited second NIR (NIR-II, 1000–1700 mainly due to lack of NIR-II absorbing contrast agents. We herein report synthesis a broadband PA agent based semiconducting polymer nanoparticles (SPN-II) apply it window. SPN-II can absorb both NIR-I regions, providing feasibility...
We have developed a class of blackbody materials, i.e., hyperbranched Au plasmonic blackbodies (AuPBs), compact sizes (<50 nm). The AuPBs were prepared in seedless and surfactant-free approach based on the use mussel-inspired dopamine. Strong intraparticle coupling among branches close proximity leads to intense uniform broadband absorption across 400–1350 nm. imparts AuPB with superior photothermal efficiency >80% closely matched activity first near-infrared (NIR-I) second (NIR-II) spectral...
Photoacoustic (PA) imaging in the second near-infrared (NIR-II) window (1000-1700 nm) holds great promise for deep-tissue diagnosis due to reduced light scattering and minimized tissue absorption; however, exploration of such a noninvasive technique is greatly constrained by lack biodegradable NIR-II absorbing agents. Herein, first series metabolizable PA agents are reported based on semiconducting polymer nanoparticles (SPNs). Such completely organic nanoagents consist π-conjugated yet...
Organic semiconducting nanoprobes doped with bulky borane can undergo specific activation by ONOO- even at tumor-relevant acidic pH (6.8), permitting in vivo ratiometric photoacoustic imaging of the tumor environment living mice.
Tumor phototheranostics in the second near-infrared window (NIR-II, 1000–1700 nm) holds great promise due to high spatiotemporal precision, enhanced penetration depth, and therapeutic efficacy. However, current "always-on" NIR-II phototheranostic agents remain restricted by inherent nonspecificity from pseudosignal readout undesirable treatment-related side effects. To address these challenges, herein we explore an activatable biocompatible nanotheranostics that generates diagnostic effects...
To evaluate in vivo sentinel lymph node (SLN) mapping by using photoacoustic and ultrasonographic (US) imaging with a modified clinical US system.Animal protocols were approved the Animal Studies Committee. Methylene blue dye accumulation axillary nodes of seven healthy Sprague-Dawley rats was imaged system adapted from system. investigate translation, depth extended up to 2.5 cm adding chicken or turkey breast on top rat skin surface. Three-dimensional images acquired mechanically scanning...
We present a novel temperature-sensing technique using thermoacoustic and photoacoustic measurements. This noninvasive method has been demonstrated tissue phantom to have high temporal resolution temperature sensitivity. Because both signal amplitudes depend on the of source object, can be used monitor temperature. A sensitivity 0.15°C was obtained at as short 2 s, taking average 20 signals. The deep-tissue imaging capability this potentially lead us in vivo monitoring thermal or cryogenic...
We have developed a novel scanner for breast cancer detection, integrating both thermoacoustic and photoacoustic techniques to achieve dual contrast (microwave light absorption) imaging. This is nonionizing, low cost, can potentially provide high‐resolution, modality three‐dimensional images of the breast. The uses front instead side compression dry gel ultrasonic coupling. Here we present design along with initial tissue phantom study results as precursor an actual patient study.
Photoacoustic tomography (PAT) combines optical and acoustic imaging to generate highresolution images of microvasculature. Inherent sensitivity hemoglobin permits PAT image blood vessels but precludes discriminating neovascular from maturing αvβ3-Gold nanobeacons (αvβ3-GNBs) for molecular were developed, characterized, demonstrated in vivo using a mouse Matrigel-plug model angiogenesis. results microscopically corroborated with fluorescent αvβ3-GNB localization supporting immunohistology...
We have developed a novel carbon nanotube-based contrast agent for both thermoacoustic and photoacoustic tomography. In comparison to deionized water, single-walled nanotubes exhibited more than twofold signal enhancement tomography at 3 GHz. blood, they sixfold 1064 nm wavelength. The large of was further corroborated by tissue phantom imaging studies.
Photoacoustic tomography systems that uses Q-switched Nd:YAG/OPO pulsed lasers are expensive, bulky, and hence limits its use in clinical applications. The low pulse repetition rate of these makes it unsuitable for real-time imaging when used with single-element ultrasound detector. In this work, we present a laser diode photoacoustic (PLD-PAT) system integrates compact PLD inside single-detector circular scanning geometry. We compared performance against the traditional based PAT terms...
Photoacoustic tomography (PAT) is a noninvasive imaging modality combining the benefits of optical contrast at ultrasonic resolution. Analytical reconstruction algorithms for photoacoustic (PA) signals require large number data points accurate image reconstruction. However, in practical scenarios, are collected using limited transducers along with being often corrupted noise resulting only qualitative images. Furthermore, boundary band-limited due to bandwidth (BW) transducer, making PA...
Abstract Four new N ‐ethylcarbazole‐linked aza‐boron‐dipyrromethene (aza‐BODIPY) dyes ( 8 a , b and 9 ) were synthesized characterized. The presence of the ‐ethylcarbazole moiety shifts their absorption fluorescence spectra to near‐infrared region, λ ≈650–730 nm, electromagnetic spectrum. These possess strong molar absorptivity in range 3–4×10 4 m −1 cm with low quantum yields. triplet excited state singlet oxygen generation these enhanced upon iodination at core position. core‐iodinated...