A5049130282- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Retinoids in leukemia and cellular processes
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Inflammatory mediators and NSAID effects
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Cells and Metastasis
- Metabolism, Diabetes, and Cancer
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related gene regulation
- Gastric Cancer Management and Outcomes
- Single-cell and spatial transcriptomics
Zhongshan Hospital
2019-2025
Sun Yat-sen University
2019-2025
The First Affiliated Hospital, Sun Yat-sen University
2019-2025
Fudan University
2019-2025
Jiangsu Agri-animal Husbandry Vocational College
2023
Tianjin University of Science and Technology
2021
Abstract Targeting ferroptosis, an iron-dependent form of regulated cell death triggered by the lethal overload lipid peroxides, in cancer therapy is impeded our limited understanding intersection tumour’s metabolic feature and ferroptosis vulnerability. In present study, arginine identified as a ferroptotic promoter using metabolites library. This effect mainly achieved through arginine’s conversion to polyamines, which exerts their potent ferroptosis-promoting property H 2 O -dependent...
Lung adenocarcinoma (LUAD) is one of the most common malignancies worldwide. Combination chemotherapy with cisplatin (CDDP) plus pemetrexed (PEM) remains predominant therapeutic regimen; however, chemoresistance greatly limits its curative potential. Here, through CRISPR-Cas9 screening, we identified miR-6077 as a key driver CDDP/PEM resistance in LUAD. Functional experiments verified that ectopic overexpression desensitized LUAD cells to both cell lines and patient-derived xenograft models....
Ferroptosis is an iron-dependent form of regulated cell death induced by the lethal overload lipid peroxides in cellular membranes. In recent years, modulating ferroptosis has gained attention as a potential therapeutic approach for tumor suppression. current study, retinol saturase (RETSAT) was identified significant mediator using publicly accessible CRISPR/Cas9 screening dataset. RETSAT depletion protected cells from peroxidation and subsequent triggered various inducers. Furthermore,...
EGF receptor (EGFR) tyrosine kinase inhibitors (TKIs) have achieved clinical success in lung adenocarcinoma (LUAD). However, tumors often show profound but transient initial response and then gain resistance. We identify transcription factor ZNF263 as being significantly decreased osimertinib-resistant or drug-tolerant persister LUAD cells residual tumors. overexpression improves the of delays formation with osimertinib treatment. further that binds recruits DNMT1 to EGFR gene promoter,...
Malignant tumor represents a major reason for death in the world and its incidence is growing rapidly. Developing tools early diagnosis possibly promising way to offer diverse therapeutic options promote survival chance. Secreted phosphoprotein 1 (SPP1), also called Osteopontin (OPN), has been demonstrated overexpressed many cancers. However, specific role of SPP1 prognosis, gene mutations, changes miRNA expression human cancers unclear. In this report, we found was higher most Based on...
Esophageal squamous cell carcinoma (ESCC) accounts for 90% of all cases esophageal cancers worldwide. Although neoadjuvant chemotherapy (NACT-ESCC) improves the survival ESCC patients, five-year rate these patients is dismal. The tumor microenvironment (TME) and heterogeneity decrease efficacy therapy. In our study, 113,581 cells obtained from five who underwent surgery alone (SA-ESCC) preoperative paclitaxel plus platinum (NACT-ESCC), were used scRNA-seq analysis to explore molecular...
Abstract Objectives Platinum-based chemotherapies are currently the first-line treatment of non-small cell lung cancer. This study will improve our understanding causes resistance to cisplatin, especially in adenocarcinoma (LUAD) and provide a reference for therapeutic decisions clinical practice. Methods Cancer Cell Line Encyclopedia (CCLE), The Genome Atlas (TCGA) Zhongshan hospital affiliated Fudan University (zs-cohort) were used identify multi-omics differences related platinum...
Esophageal squamous cell carcinoma (ESCC) is the most common pathological type of esophageal cancer in China, accounting for more than 90 %. Most patients were diagnosed with advanced-stage ESCC, whom new adjuvant therapy recommended. Therefore, it urgent to explore therapeutic targets ESCC. Ferroptosis, a newly discovered iron-dependent programmed death, has been shown play an important role carcinogenesis by many studies. This study explored effect Polo like kinase 1 (PLK1) on...
KRAS is among the most commonly mutated oncogenes in human malignancies. Although advent of sotorasib and adagrasib, has lifted "undruggable" stigma KRAS, resistance to inhibitors quickly becomes a major issue. Here, we reported that aldehyde dehydrogenase 1 family member A1 (ALDH1A1), an enzyme retinoic acid biosynthesis redox balance, increases response confers range cancer types. inhibitors' efficacy significantly improved sensitive or drug-resistant cells, patient-derived organoids...
Background: The role of ferroptosis in esophageal squamous cell carcinoma (ESCC) is still unclear. Methods: association iron metabolism and ferroptosis-related genes with the prognosis, copy number variation (CNV), TMB, immune infiltration ESCC was explored using data from GEO TCGA database validated by immunofluorescence 112 patients our center. potential anti-cancer drugs compounds GDSC Connectivity Map were also screened. Results: A total 117 identified. We found expressions PRNP, SLC3A2,...
Abstract Ferroptosis is a type of regulated cell death characterized by iron accumulation and lipid peroxidation. The molecular mechanisms underlying ferroptosis regulation in non-small lung cancer (NSCLC) are poorly understood. In this study, we found that protein kinase A (PKA) inhibition enhanced susceptibility NSCLC cells, as evidenced reduced viability increased We further identified cAMP-responsive element 1 (CREB1), transcription factor substrate PKA, key regulator ferroptosis....
Abstract Background Single‐cell transcriptomics has been used to investigate various tumors elucidate the molecular distinction of all cell type compositions a complex mix. Aims This study aimed malignant‐cell‐specific genes explore diagnostic and therapeutic biomarkers using single‐cell transcriptomic data lung adenocarcinoma. Materials & Methods 10X RNA‐seq fourteen patients with adenocarcinoma were analyzed. Genes that expressed differentially those higher confidence distinguish tumor...
Abstract Ferroptosis, a type of iron-dependent non-apoptotic cell death, plays vital role in both tumor proliferation and resistance to chemotherapy. Here, our study demonstrates that MAX’s Next Tango (MNT), by involving itself the spermidine/spermine N1-acetyltransferase 1 (SAT1)-related ferroptosis pathway, promotes lung adenocarcinoma (LUAD) cells diminishes their sensitivity Initially, an RNA-sequence screen LUAD treated with inducers (FINs) reveals significant increase MNT expression,...
Abstract Ferroptosis is a recently discovered form of cell death that plays an important role in tumor growth and holds promise as target for antitumor therapy. However, evidence the regulation ferroptosis lung adenocarcinoma (LUAD) remains elusive. Here, we show retinoic acid receptor alpha ( RARA ) upregulated with treatment inducers (FINs). Pharmacological activation increases resistance LUAD to according viability lipid peroxidation assays, while inhibitor or knockdown (KD) does...