Circular RNAs (circRNAs) play important regulatory roles in multiple human malignancies, including non-small cell lung cancer (NSCLC). Here, we explored the role of circRNA vacuole membrane protein 1 (circVMP1) NSCLC progression and cisplatin (DDP) resistance.The DDP resistance, proliferation, sphere formation ability, migration, invasion, apoptosis cells were analyzed by Cell Counting Kit-8 (CCK8) assay, 5-ethynyl-2'-deoxyuridine (EdU) wound healing Transwell flow cytometry. Methylated...

Malignant tumor represents a major reason for death in the world and its incidence is growing rapidly. Developing tools early diagnosis possibly promising way to offer diverse therapeutic options promote survival chance. Secreted phosphoprotein 1 (SPP1), also called Osteopontin (OPN), has been demonstrated overexpressed many cancers. However, specific role of SPP1 prognosis, gene mutations, changes miRNA expression human cancers unclear. In this report, we found was higher most Based on...

OBJECTIVESTo study the feasible and safe volume threshold for chest tube removal following video-assisted thoracoscopic surgical lobectomy.

The application of cancer chronotherapy is to treat cancers based on at specific times during circadian rhythms.Previous studies have characterized the impact clock tumorigenesis and immune cells.Here, by using multi-omics computation techniques, we systematically distinct roles core genes in thoracic including lung adenocarcinoma, squamous cell carcinoma, esophageal carcinoma.Strikingly, a wide range are epigenetically altered adenocarcinomas carcinomas but not carcinomas.Further hallmark...

Circulating tumor cells (CTCs) are an independent prognostic marker in non-small cell lung cancer (NSCLC). CTC numbers closely related to early diagnosis, clinical stage, therapy surveillance, and prognosis of NSCLC. We used a more efficient nano-enrichment method detect CTCs NSCLC patients explored the value CTCs. The results showed that stage IV cases were significantly higher than those I, II or III cases. number poorly-differentiated was well-differentiated During six chemotherapy...

As a key element in the T-helper 17 (Th17) cell-mediated inflammatory process, interleukin-23 receptor (IL-23R) plays crucial role pathogenesis of cancer. Single nucleotide polymorphisms (SNPs) IL-23R have been frequently studied several previous case-control cancer studies, but its association with esophageal squamous cell carcinoma (ESCC) Chinese population has not investigated. This study examined whether genetic were associated ESCC susceptibility.A hospital-based 684 patients and 1064...

This study analyzed the clinical features and prognosis of basaloid squamous cell carcinoma lung (BSC), constructed a nomogram to predict prognoses patients.The information pure BSC patients was obtained in Surveillance, Epidemiology, End Results database between 2004 2015. Then, it evaluated, compared with data (SCC), large (LCC) adenocarcinoma (LAC) patients. Subsequently, we used univariate multivariate analyses investigate independent factors related verify prognoses.A total 425...

To discuss the feasibility, safety and superiority of novel approaches in single-port video-assisted thoracoscopic wedge resection different genders. The clinical data patients who underwent pulmonary were analysed. A total 197 consecutive male from January 2012 to December 2014, 72 female June 2013 2014 included retrospectively. Of males, 65 received a transareolar procedure (TASP Group) 132 standard two-port (Standard Group A). Among females, 18 treated with subxiphoid (SXSP Group), 54 B)....

MicroRNAs (miRNAs/miRs) in extracellular vesicles (EVs) are potential diagnostic markers. The purpose of the present study was to investigate EV miRNA biomarkers for lung adenocarcinoma (LUAD). Potential miRNAs were identified by searching public databases and verified examining clinical samples. value EV‑associated miR‑10b, plasma miR‑10b tumor markers (TMs), including α‑fetoprotein (AFP), neuron‑specific enolase, carcinoembryonic antigen (CEA), cytokeratin 19 fragment 21‑1 (CYFRA211),...

Aberrant epigenetic remodeling represents a molecular hallmark in lung adenocarcinoma (LUAD). We aim to investigate the biological roles of SETDB2 and its underlying associations with oxidative stress, providing therapeutic targets for individualized treatment LUAD.Differential analysis was conducted via Limma package, Kaplan-Meier performed survival package. CCK-8, cell proliferation assay, transwell vivo assays were assess function SETDB2. Western blot RT-qPCR, immunohistochemistry (IHC)...

Thoracoscopic sympathectomy (TS) has been proven to be a safe and effective treatment for primary palmar hyperhidrosis (PH). However, the complications include compensatory (CH), over-dry hands may occur in some patients after TS.

Esophageal large cell neuroendocrine carcinoma (ELCNC) seems a rarely gastrointestinal malignancy. By far, its clinicopathological characteristics and prognosis have not been deeply studied.The data of patients having ELCNC was extracted from the Surveillance, Epidemiology, End Results (SEER) database, then assessed compared with information esophageal small (ESCNC) or squamous (ESCC). We used univariate multivariate analyses to accurately detect independent prognostic factors.The 36 for...

ObjectiveTo investigate the clinical significance of cyclin-dependent kinase 14 (CDK14) expression in patients with non-small cell lung cancer (NSCLC).MethodsThe present prospective observational study included 193 diagnosed NSCLC between January 2010 and December 2014. tumor tissues paired paracancerous normal were obtained from all patients. CDK14, thyroid transcription factor 1 (TTF-1), cytokeratin 5/6 (CK5/6), Ki67 was measured via immunohistochemistry (IHC)ResultsCDK14 staining strong...

From an oncologic perspective, genetic detection is becoming a frontline clinical test, used to identify actionable alterations for targeted therapy, monitor molecular clonal tumor evolution, indicate disease progression and prognosis, predict medication efficacy resistance. analysis of both tissue cell-free DNA from large cohort non-small cell lung cancer patients in East-China, we characterized the full spectrum genomic alterations.The study comprised 3000 unpaired samples including 1351...

To investigate the feasibility of a new mode to diagnose and treat intrathoracic gastroesophageal anastomotic leak.From January 2007 December 2014, fifty-five patients were confirmed leak among those performed surgical operation due esophageal or cardiac carcinoma in First Affiliated Hospital Soochow University. retrospectively analyze clinical data these patients, thirty-six male nineteen female included with ages from 49 81 years (average age (67±6)years). Among them, forty-two middle...

Objective: Excision of rib tumors by conventional surgical method often results in poor prognosis due to trauma and heavily bleeding.In the present study, we evaluated advantages applying computer navigation-assisted thoracoscope resection tumors.Methods: Prior surgery, pathology bearing regions 4 patients were scanned tomography (CT) margin was predetermined.During operation, fusion image 3-dimensional navigation scanning CT clearly provided guidance for tumor minimally invasive...

Objective To investigate the occurrence, development and prognosis of pulmonary alveolar microlithiasis (PAM), improve understanding PAM. Methods A case with pneumothorax was reported in Department Thoracic Surgery, Suzhou Hospital affiliated to Nanjing Medical University, related literatures were reviewed. Results PAM a rare autosomal recessive disease familial aggregation.SLC34A2 gene mutation cause PAM.There no obvious symptom early stage disease.The high resolution computed...