A5031659624- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Scoliosis diagnosis and treatment
- Ferroptosis and cancer prognosis
- Prostate Cancer Treatment and Research
- RNA modifications and cancer
- Prostate Cancer Diagnosis and Treatment
- Microbial bioremediation and biosurfactants
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Bone Tissue Engineering Materials
- Dysphagia Assessment and Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- Orthopaedic implants and arthroplasty
- Inflammatory Biomarkers in Disease Prognosis
- Graphene and Nanomaterials Applications
- Pelvic and Acetabular Injuries
- Histone Deacetylase Inhibitors Research
- Microbial Community Ecology and Physiology
- Tracheal and airway disorders
- Epigenetics and DNA Methylation
ShenZhen People’s Hospital
2023-2025
First Affiliated Hospital of Zhengzhou University
2017-2024
Nanjing Medical University
2022-2024
Jiangsu Cancer Hospital
2024
The People's Hospital of LinXia
2023-2024
Nanchang Institute of Technology
2024
Southern Medical University
2023-2024
West China Hospital of Sichuan University
2017-2023
Sichuan University
2017-2023
Sun Yat-sen University
2022-2023
Abstract Background Biosurfactants, being highly biodegradable, ecofriendly and multifunctional compounds have wide applications in various industrial sectors including environmental bioremediation. Surfactin, a member of lipopeptide family, which is considered as one the most powerful biosurfactants due to its excellent emulsifying activities well therapeutic applications. Therefore, aim this study was investigate newly isolated bacterial strain S2MT for production surfactin-like their...
In this work, we developed the first 3D-printed polyetheretherketone (PEEK)-based bone scaffold with multi-functions targeting challenging diseases such as osteosarcoma and osteomyelitis. A PEEK/graphene nanocomposite was deposited a drug-laden (antibiotics and/or anti-cancer drugs) hydroxyapatite coating. The graphene nanosheets within served effective photothermal agents that endowed on-demand conversion function under near-infrared laser irradiation. bioactive coating significantly...
Abstract A poor seal of the titanium implant–soft tissue interface provokes bacterial invasion, aggravates inflammation, and ultimately results in implant failure. To ensure long‐term success implants, lactoferrin‐derived amyloid is coated on surface to increase expression cell integrins hemidesmosomes, with goal promoting soft imparting antibacterial activity implants. The structures contain a large number amino carboxyl groups their surfaces, promote proliferation adhesion epithelial cells...
Mounting evidence has revealed that the interactions and dynamic alterations among immune cells are critical in shaping tumor microenvironment ultimately map onto heterogeneous clinical outcomes. Currently, underlying significance of cell evolutions remains largely unexplored hepatocellular carcinoma (HCC). A total 3,817 1,750 HCC patients 15 independent public datasets were retrieved. The Seurat Monocle algorithms used to depict T evolution, nonnegative matrix factorization (NMF) was...
There is an urgent need for reliable and effective models to study air pollution health effects on human lungs. Here, we report the utilization of pluripotent stem cell (hPSC) induction lung progenitor cells (hLPs) alveolar type 2 epithelial cell-like (ATLs) toxicity assessment benzo(a)pyrene, nano-carbon black, nano-SiO2, as common pollutants. We induced hPSCs generate ATLs, which recapitulated key features cells, tested cellular uptake nanoparticles evaluations. Our findings reveal...
According to increasing evidence, high-density lipoproteins (HDLs) may raise prostate-specific antigen (PSA) levels in the prostate. The link between HDL-cholesterol (C) and PSA, on other hand, is debatable challenging. Hence, present study examined relationship HDL-C PSA men using National Health Nutrition Examination Survey (NHANES) database. NHANES data were extracted for five cycles from 2001 2010. used analysis included concentrations, sociodemographic laboratory data. After screening,...
Dominant defects in CHCHD10, a mitochondrial intermembrane space protein, lead to range of neurological and muscle disease phenotypes including amyotrophic lateral sclerosis. Many patients present with spinal muscular atrophy Jokela type (SMAJ), which is caused by heterozygous p.G66V variant. While most variants aggregation CHCHD10 activation proteotoxic stress responses, the pathogenic mechanisms variant are less clear. Here we report first homozygous patient, show that dosage dictates...
Backgrounds: To build a model for proximal junctional kyphosis (PJK) prognostication in Lenke 5 adolescent idiopathic scoliosis (AIS) patients undergoing long posterior instrumentation and fusion surgery by machine learning analyze the risk factors PJK. Materials Methods: In total, 44 AIS (Female/male: 34/10; PJK/non-PJK: 34/10) who met inclusion criteria between January 2013 December 2018 were retrospectively recruited from West China Hospital. Thirty-seven clinical radiological features...
Previous studies have found satisfactory clinical results with the nano-hydroxyapatite/polyamide 66 (n-HA/PA66) cage to reconstruct stability of anterior cervical column. However, evaluating long-term outcomes n-HA/PA66 in multi-level degenerative myelopathy (MDCM) not been reported. This study aims compare corpectomy discectomy and fusion (ACDF) hybrid procedures between titanium mesh (TMC) treat MDCM.After screening for eligibility, this retrospective involved 90 patients who underwent...
The tumor heterogeneity is an important cause of clinical therapy failure and yields distinct prognosis in ovarian cancer (OV). Using the advantages integrated single cell RNA sequencing (scRNA-seq) bulk data to decode remains largely unexplored. Four public datasets were enrolled this study, including E-MTAB-8107, TCGA-OV, GSE63885, GSE26193 cohorts. Random forest algorithm was employed construct a multi-gene prognostic panel further evaluated by receiver operator characteristic (ROC),...
Abstract Background PIA has been proven to be a predictor for postoperative dysphagia in patients who undergo occipitospinal fusion. However, its predictive effect OCF is unknown. The aim of this study was evaluate the ability pharyngeal inlet angle (PIA) occurrence occipitocervical fusion (OCF). Methods Between 2010 and 2018, 98 had undergone were enrolled reviewed. Patients divided into two groups according presence dysphagia. Radiographic parameters, including atlas-dens interval (ADI),...