A5030131762- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Bacillus and Francisella bacterial research
- COVID-19 Clinical Research Studies
- Cytomegalovirus and herpesvirus research
- Algal biology and biofuel production
- Virus-based gene therapy research
- Plant-Microbe Interactions and Immunity
- Plant Stress Responses and Tolerance
- vaccines and immunoinformatics approaches
- Nutritional Studies and Diet
- Enzyme Catalysis and Immobilization
- Microbial Natural Products and Biosynthesis
- Insect and Arachnid Ecology and Behavior
- Animal Disease Management and Epidemiology
- Plant Gene Expression Analysis
- Respiratory viral infections research
- Marine Sponges and Natural Products
- Cancer Treatment and Pharmacology
- COVID-19 Impact on Reproduction
- Immune Response and Inflammation
- Blood Pressure and Hypertension Studies
- RNA and protein synthesis mechanisms
Yantai Institute of Coastal Zone Research
2025
Chinese Academy of Sciences
2020-2025
Fujian Medical University
2025
Union Hospital
2025
Anhui Agricultural University
2022-2025
Yangzhou University
2024
First Affiliated Hospital of Zhengzhou University
2024
Institute of Biophysics
2020-2024
Xian Center for Disease Control and Prevention
2024
Central South University
2024
The SARS-CoV-2 Omicron variant with increased fitness is spreading rapidly worldwide. Analysis of cryo-EM structures the spike (S) from reveals amino acid substitutions forging interactions that stably maintain an active conformation for receptor recognition. relatively more compact domain organization confers improved stability and enhances attachment but compromises efficiency viral fusion step. Alterations in local conformation, charge, hydrophobic microenvironments underpin modulation...
Abstract Omicron (B.1.1.529), the most heavily mutated SARS-CoV-2 variant so far, is highly resistant to neutralizing antibodies, raising concerns about effectiveness of antibody therapies and vaccines 1,2 . Here we examined whether sera from individuals who received two or three doses inactivated vaccine could neutralize authentic Omicron. The seroconversion rates antibodies were 3.3% (2 out 60) 95% (57 for had 2 3 vaccine, respectively. For recipients doses, geometric mean neutralization...
Broad-spectrum resistance is highly preferred in crop breeding programmes. Previously, we have reported the identification of broad-spectrum resistance-Digu 1 (bsr-d1) allele from rice Digu. The bsr-d1 prevents activation Bsr-d1 expression by Magnaporthe oryzae infection and degradation H2 O2 peroxidases, leading to M. oryzae. However, it remains unknown whether defence pathways other than burst peroxidases contribute bsr-d1-mediated immunity. Blast was determined leaves spray punch...
Abstract Emergence of variants concern (VOC) with altered antigenic structures and waning humoral immunity to SARS-CoV-2 are harbingers a long pandemic. Administration third dose an inactivated virus vaccine can boost the immune response. Here, we have dissected immunogenic profiles antibodies from 3-dose vaccinees, 2-dose vaccinees convalescents. Better neutralization breadth VOCs, expeditious recall long-lasting response bolster in warding off COVID-19. Analysis 171 complex neutralizing...
Lodging is a common problem in rice, reducing its yield and mechanical harvesting efficiency. Rice architecture key aspect of domestication major factor that limits high productivity. The ideal rice culm structure, including major_axis_culm, minor axis_culm, wall thickness_culm, critical for improving lodging resistance. However, the traditional method measuring culms destructive, time consuming, labor intensive. In this study, we used high-throughput micro-CT-RGB imaging system deep...
Background: Mendelian randomization studies of systolic blood pressure (SBP) can assess the shape and strength associations genetically predicted differences in SBP with major disease outcomes are less constrained by biases observational analyses. This study aimed to compare usual cardiovascular (CVD) outcomes, overall levels SBP, age, sex. Methods: The China Kadoorie Biobank involved a 12-year follow-up prospective 489 495 adults aged 40 79 years no prior CVD 86 060 genetic data. Outcomes...
Abstract New threats posed by the emerging circulating variants of SARS-CoV-2 highlight need to find conserved neutralizing epitopes for therapeutic antibodies and efficient vaccine design. Here, we identified a receptor-binding domain (RBD)-binding antibody, XG014, which potently neutralizes β-coronavirus lineage B (β-CoV-B), including SARS-CoV-2, its variants, SARS-CoV bat SARSr-CoV WIV1. Interestingly, antibody family members competing with XG014 binding show reduced levels...
Abstract Porcine epidemic diarrhea virus (PEDV) is a highly contagious coronavirus that causes severe and death, particularly in neonatal piglets. The nucleocapsid protein (N protein) of PEDV presents strong immunogenicity contributes to the cross-reactivity between TGEV. However, characterization epitopes on N remains largely unknown. Here, two monoclonal antibodies (MAbs) specific strain, FJzz1/2011, were generated screened against partially overlapping library 24 GST-fusion...
Hypoxia and high glutathione (GSH) contents in the tumor microenvironment (TME) diminish efficacy of single-modality photodynamic therapy (PDT) chemodynamic (CDT). Cu2O can effectively release Cu+ within TME, facilitating CDT, concurrently generate O2 to mitigate hypoxia. Co-delivery with photosensitizers (PSs) tumors could potentially enhance PDT/CDT combination therapy. However, challenges such as instability, susceptibility vivo substances affecting catalytic activity, toxicity normal...
ABSTRACT E3 ubiquitin ligases are major components of the ubiquitination cascade and contribute to stomatal responses pathogen drought stress in plants. The F‐box SKP1‐Interacting Partners (AtSKIPs) proteins members SCF ligase complexes; however, whether they have any involvement movement remains unclear. Here, based on tissue expression profiling, we found that AtSKIP5 protein was highly expressed guard cells. Mutation rendered plants more susceptible Pseudomonas syringae pv. tomato (Pst)...
Stomatal immunity and apoplastic are critical for preventing microbial phytopathogenesis. However, the specific regulatory mechanisms of these resistances remain unclear. In this study, a BBX11 transcription factor (TF) was identified in Arabidopsis found to participate stomatal apoplast immunity. Phenotypic, biochemical, genetic analyses revealed that NAC053 contributed resistance against Pseudomonas syringae pv tomato DC3000 (Pst DC3000) by positively regulating BBX11. TF expressed...
Systemic lupus erythematosus (SLE) is an autoimmune disease, and when it presents with neurological complications, termed neuropsychiatric systemic (NPSLE). Cortical laminar necrosis (CLN) refers to the of neurons in one or more layers cerebral cortex. This report a case NPSLE CLN 43-year-old female patient, diagnosis was based on clinical manifestations MRI. The pathogenesis complex, its presentations are varied. Thus, future research should focus enhancing understanding this disease...
Abstract Receptor usage that determines cell tropism and drives viral classification closely correlates with the virus structure. Enterovirus B (EV-B) consists of several subgroups according to receptor usage, among which echovirus 30 (E30), a leading causative agent for human aseptic meningitis, utilizes FcRn as an uncoating receptor. However, receptors many EVs remain unknown. Here we analyzed atomic structures E30 mature virion, empty- A-particles, reveals serotype-specific epitopes...
Background: The effect of flavonoid consumption on all-cause and special-cause mortality remains unclear among populations with hypertension. Methods: A total 6110 people hypertension from three NHANES survey cycles (2007–2008, 2009–2010, 2017–2018) were enrolled in this study. Cox proportional hazard models conducted to estimate the association between intake flavonoids subclasses all-cause, cancer-related, cardiovascular disease (CVD)-related mortality. Nonlinear relationships identified...
Abstract Echovirus 30 (E30), a serotype of Enterovirus B (EV-B), recently emerged as major causative agent aseptic meningitis worldwide. E30 is particularly devastating in the neonatal population and currently no vaccine or antiviral therapy available. Here we characterize two highly potent E30-specific monoclonal antibodies, 6C5 4B10, which efficiently block binding virus to its attachment receptor CD55 uncoating FcRn. Combinations 4B10 augment sum their individual anti-viral activities....