A5033777911- Neurogenesis and neuroplasticity mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Anesthesia and Neurotoxicity Research
- Alzheimer's disease research and treatments
- MicroRNA in disease regulation
- Axon Guidance and Neuronal Signaling
- Traumatic Brain Injury Research
- Neonatal Respiratory Health Research
- Memory and Neural Mechanisms
- Pluripotent Stem Cells Research
- Nerve injury and regeneration
- S100 Proteins and Annexins
- Trauma and Emergency Care Studies
- Cardiac Arrest and Resuscitation
- Genetics and Neurodevelopmental Disorders
- Sleep and Wakefulness Research
- Mitochondrial Function and Pathology
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 Clinical Research Studies
- Kawasaki Disease and Coronary Complications
- COVID-19 Impact on Reproduction
- Congenital heart defects research
Columbia University
2015-2024
Columbia University Irving Medical Center
2013-2023
Morgan Stanley Children's Hospital
2013-2022
Presbyterian Hospital
2020-2022
New York Hospital Queens
2015-2022
Faculty of 1000 (United States)
2020
NewYork–Presbyterian Hospital
2015-2020
Royal College of Physicians
2018
Columbia College
2018
The University of Texas Southwestern Medical Center
2005-2017
Clinical Characteristics of Children With SARS-CoV-2–Associated Pediatric Inflammatory Multisystem Syndrome
<h3>Importance</h3> Descriptions of the coronavirus disease 2019 (COVID-19) experience in pediatrics will help inform clinical practices and infection prevention control for pediatric facilities. <h3>Objective</h3> To describe epidemiology, clinical, laboratory features patients with COVID-19 hospitalized at a children's hospital to compare these parameters between without severe disease. <h3>Design, Setting, Participants</h3> This retrospective review electronic medical records from...
Acute seizures after a severe brain insult can often lead to epilepsy and cognitive impairment. Aberrant hippocampal neurogenesis follows the but role of adult-generated neurons in development chronic or associated deficits remains be determined. Here we show that ablation adult before pilocarpine-induced acute mice leads reduction seizure frequency. We also normalizes epilepsy-associated deficits. Remarkably, effect ablating is long lasting as it suppresses frequency for nearly 1 year....
Abstract The persistence of neural stem cells into adulthood has been an area intense investigation in recent years. There is limited knowledge about how acquired brain injury might affect the ability precursor to proliferate and repopulate injured areas. In present study we utilize a controlled cortical impact model traumatic adult mice subsequent BrdU labeling demonstrate that there significant proliferation precursors response areas both proximal distal site. fate almost exclusively...
The mechanisms underlying astrocyte heterogeneity in the developing mouse brain are poorly understood. bHLH transcription factor Olig2 is essential for motoneuron and oligodendrocyte formation; however, its role development remains obscure. During cortical development, transiently expressed immature astrocytes at neonatal stages progressively downregulated late postnatal stages. To assess function of formation, we conditionally ablated a spatiotemporally controlled manner. In Olig2-ablated...
It is becoming increasingly clear that brain injuries from a variety of causes stimulate neurogenesis within the hippocampus. remains unclear, however, how robust this response may be and what primary cell types are involved. Here, using controlled cortical impact model traumatic injury on previously characterized transgenic mouse line expresses enhanced green fluorescent protein (eGFP) under control nestin promoter, we demonstrate it earliest type-1 quiescent progenitor cells induced to...
Tuberous sclerosis complex (TSC) is a multiorgan genetic disease in which brain involvement causes epilepsy, intellectual disability, and autism. The hallmark pathological finding TSC the cerebral cortical tuber its unique constituent, giant cells. However, an animal model that replicates cells has not yet been described. Here, we report mosaic induction of Tsc1 loss neural progenitor cc Nestin-rtTA + TetOp-cre embryos by doxycycline leads to multiple neurological symptoms, including severe...
Neuronal activity enhances the elaboration of newborn neurons as they integrate into synaptic circuitry adult brain. The role microRNAs play in transduction neuronal growth and synapse formation is largely unknown. MicroRNAs can influence expression hundreds genes thus could regulate gene assemblies during processes like activity-dependent integration. Here, we developed viral-based methods for vivo detection manipulation microRNA, miR-132, mouse hippocampus. We find, using lentiviral...
Significant spontaneous recovery occurs after essentially all forms of serious brain injury, although the mechanisms underlying this are unknown. Given that many injury such as traumatic (TBI) induce hippocampal neurogenesis, we investigated whether these newly generated neurons might play a role in recovery. By modeling TBI transgenic mice, determined injury-induced persisted over time and elaborated extensive dendritic trees stably incorporated themselves throughout neuronal layers dentate...
The disease caused by severe acute respiratory syndrome coronavirus 2, known as 2019, has resulted in a global pandemic. Reports are emerging of new hyperinflammatory related to 2019 children and adolescents. Centers for Disease Control Prevention designated this multisystem inflammatory children. Our objective was develop clinical inpatient protocol the evaluation, management, follow-up patients with syndrome.
The molecular mechanism underlying progressive memory loss in Alzheimer's disease is poorly understood. Neurogenesis the adult hippocampus a dynamic process that continuously changes dentate gyrus and important for hippocampal plasticity, learning memory. However, whether impairments neurogenesis affect circuitry way leads to deficits characteristic of unknown. Controversial results regard were reported transgenic mouse models amyloidosis.Here, we conditionally ablated APPswe/PS1ΔE9 mice by...
The adult brain maintains two regions of neurogenesis from which new neurons are born, migrate to their appropriate location, and become incorporated into the circuitry CNS. One these, subgranular zone hippocampal dentate gyrus, is primary interest because role this region in learning memory. We show that mice lacking EphB1, more profoundly EphB1 EphB2, have significantly fewer neural progenitors hippocampus. Furthermore, other aspects neurogenesis, such as polarity, cell positioning,...
The mechanisms underlying the formation of glial scar after injury are poorly understood. In this report, we demonstrate that cortical Olig2 is upregulated in reactive astrocytes coincident with proliferation these cells. Short-term lineage tracing studies subtype-restricted transgenic reporter lines indicate Olig2-expressing cells astroglial but not oligodendroglial essential source astrocytes. addition, ablation results a decrease response to injury. Cell-type-specific mutagenesis...
Many genes regulating adult neurogenesis have been identified and are known to play similar roles during early neuronal development. We recently apolipoprotein E (ApoE) as a gene the expression of which is essentially absent in brain progenitors but becomes markedly upregulated dentate gyrus stem/progenitor cells. Here, we demonstrate that ApoE deficiency impairs development by affecting neural progenitor pool over time. utilized ApoE-deficient mice crossed nestin-GFP reporter cells...
The causal relationship between neurogenesis and the recovery of poststroke cognitive function has not been properly explored. current study aimed to determine whether depleting neuroprogenitor cells (NPCs) affects functional outcome in nestin-δ-HSV-TK-EGFP transgenic mice, which expression a truncated viral thymidine kinase gene EGFP was restricted nestin-expressing NPCs. Ganciclovir (GCV; 200 mg/kg/d) or saline continuously administered via osmotic pumps mice for 4 weeks before induction...
Disrupted thyroid hormone function evokes severe physiological consequences in the immature brain. In adulthood, although clinical reports document an effect of status on mood and cognition, molecular cellular changes underlying these behavioural effects are poorly understood. More recently, subtle structural plasticity mature brain, particular adult hippocampal neurogenesis, have come to be appreciated. However, specific stages progenitor development that sensitive not defined. Using...
Traumatic brain injury (TBI) is ubiquitous and effective treatments for it remain supportive largely due to uncertainty over how endogenous repair occurs. Recently, we demonstrated that hippocampal injury-induced neurogenesis one mechanism underlying following TBI. Donepezil associated with increased has long been known improve certain aspects of cognition many types through unknown mechanisms. By coupling donepezil therapy temporally regulated ablation using nestin-HSV transgenic mice,...
Adult hippocampal neurogenesis plays an important role in synaptic plasticity and cogntive function. We reported that higher numbers of neural stem cells (NSC) the hippocampus cognitively-intact individuals with high Alzheimer's disease (AD) pathology (plaques tangles) is associated decreased amyloid beta oligomers (Aβο), event linked to onset dementia AD. While these findings suggest a link between NSC resistance Aβο, involved mechanism remains be determined. With this goal mind, here we...