A5030116801- Neuroscience and Neuropharmacology Research
- Wound Healing and Treatments
- Library Science and Administration
- Paleontology and Stratigraphy of Fossils
- Neonatal and fetal brain pathology
- Chemical Synthesis and Reactions
- Geological and Geochemical Analysis
- Geochemistry and Geologic Mapping
- Epilepsy research and treatment
- Anesthesia and Neurotoxicity Research
- Pharmacological Receptor Mechanisms and Effects
- Library Collection Development and Digital Resources
- Research on Leishmaniasis Studies
- Receptor Mechanisms and Signaling
- Geological Formations and Processes Exploration
- Photoreceptor and optogenetics research
- Geology and Paleoclimatology Research
- Radiation Therapy and Dosimetry
- Mitochondrial Function and Pathology
- Library Science and Information Literacy
- Cancer therapeutics and mechanisms
- Memory and Neural Mechanisms
- Protein Kinase Regulation and GTPase Signaling
- PI3K/AKT/mTOR signaling in cancer
- Neurogenesis and neuroplasticity mechanisms
Stanford University
2019-2025
Palo Alto University
2023
Charlottesville Medical Research
2020
University of Virginia
1989-2020
Boston Children's Hospital
2011-2015
Harvard University
2011-2013
Cheltenham Festivals
2013
Klinikum Konstanz
2011
Olgahospital
2011
Imaging Center
2011
Muscle injuries represent a major part of sports and are challenging problem in traumatology. Strain the most common muscle after contusions. These can lead to significant pain disability causing time be lost training competition. Despite frequency strain treatment available is limited generally not sufficient enhance regeneration efficiently when fast resumption sport activity primary target. A number growth factors play specific role it has been proven that previously described method...
Early life seizures can result in chronic epilepsy, cognitive deficits and behavioral changes such as autism, conversely epilepsy is common autistic children. We hypothesized that during early brain development, could alter regulators of synaptic development underlie the interaction between autism. The mammalian Target Rapamycin (mTOR) modulates protein translation dysregulated Tuberous Sclerosis Complex, a disorder characterized by used rodent model acute hypoxia-induced neonatal results...
Tuberous sclerosis complex (TSC) is a multiorgan genetic disease in which brain involvement causes epilepsy, intellectual disability, and autism. The hallmark pathological finding TSC the cerebral cortical tuber its unique constituent, giant cells. However, an animal model that replicates cells has not yet been described. Here, we report mosaic induction of Tsc1 loss neural progenitor cc Nestin-rtTA + TetOp-cre embryos by doxycycline leads to multiple neurological symptoms, including severe...
Summary Purpose: To study the development of epilepsy following hypoxia‐induced neonatal seizures in Long‐Evans rats and to establish presence spontaneous this model early life seizures. Methods: rat pups were subjected at postnatal day 10 (P10). Epidural cortical electroencephalography (EEG) hippocampal depth electrodes used detect later adulthood (>P60). In addition, subdermal wire electrode recordings monitor age onset progression juvenile period, intervals between P10 P60. Timm...
As NASA prepares for a mission to Mars, concerns regarding the health risks associated with deep space radiation exposure have emerged. Until now, impacts of such exposures only been studied in animals after acute exposures, using dose rates ∼1.5×105 higher than those actually encountered space. Using new, low dose-rate neutron irradiation facility, we uncovered that realistic, produce serious neurocognitive complications impaired neurotransmission. Chronic (6 month) low-dose (18 cGy) and...
The axon initial segment of hippocampal pyramidal cells is a key subcellular compartment for action potential generation, under GABAergic control by the "chandelier" or axo-axonic (AACs). Although AACs are only cellular source GABA targeting segment, their in vivo activity patterns and influence over cell dynamics not well understood. We achieved cell-type-specific genetic access to mice show that area CA1 synchronously activated episodes locomotion whisking during rest. Bidirectional...
Locomotor speed is a basic input used to calculate one’s position, but where this signal comes from unclear. We identified neurons in the supramammillary nucleus (SuM) of rodent hypothalamus that were highly correlated with future locomotor and reliably drove locomotion when activated. Robust control was specifically
Abstract Technological advancements have facilitated the implementation of realistic, terrestrial-based complex 33-beam galactic cosmic radiation simulations (GCR Sim) to now probe central nervous system functionality. This work expands considerably on prior, simplified GCR simulations, yielding new insights into responses male and female mice exposed 40–50 cGy acute or chronic radiations relevant deep space travel. Results object in updated location task suggested that exposure Sim induced...
Abstract Epilepsy is a prevalent disorder involving neuronal network hyperexcitability, yet existing therapeutic strategies often fail to provide optimal patient outcomes. Chemogenetic approaches, where exogenous receptors are expressed in defined brain areas and specifically activated by selective agonists, appealing methods constrain overactive activity. We developed BARNI (Bradanicline- Acetylcholine-activated Receptor for Neuronal Inhibition), an engineered channel comprised of the α7...
Poly-alpha-(l-glutamic acid) (PG) conjugates of 20(S)-camptothecin (1, CPT) displayed improved aqueous solubility compared to CPT, were stable in solution at neutral pH, and potent antitumor agents vivo. Evaluation PG molecular weight, CPT loading, solubility, equivalent dosing with respect vivo potencies various linked led identification a preferred conjugate composition.
Abstract Aldosterone-producing zona glomerulosa (zG) cells of the adrenal gland arrange in distinct multi-cellular rosettes that provide a structural framework for cortex morphogenesis and plasticity. Whether this cyto-architecture also plays functional roles signaling remains unexplored. To determine if structure informs function, we generated mice with zG-specific expression GCaMP3 imaged zG within their native rosette structure. Here demonstrate rosette, angiotensin II evokes periodic Ca...
Summary Purpose To determine whether AMPA receptor ( AMPAR ) antagonist NBQX can prevent early mammalian target of rapamycin (m TOR pathway activation and long‐term sequelae following neonatal seizures in rats, including later‐life spontaneous recurrent seizures, CA 3 mossy fiber sprouting, autistic‐like social deficits. Methods L ong‐ E vans rats experienced hypoxia‐induced HS at postnatal day P )10. (20 mg/kg) was administered immediately (every 12 h × 4 doses). Twelve hours post‐ , we...
Neonatal seizures can lead to later life epilepsy and neurobehavioral deficits, there are no treatments prevent these sequelae. We showed previously that hypoxia-induced in a neonatal rat model induce rapid phosphorylation of serine-831 (S831) Serine 845 (S845) sites the AMPA receptor GluR1 subunit neuronal hyperexcitability epilepsy, suggesting seizure-induced posttranslational modifications may represent novel therapeutic target. To unambiguously assess contribution sites, we examined...
Chronic hyperoxia during the first 1–4 postnatal weeks attenuates hypoxic ventilatory response (HVR) subsequently measured in adult rats. Rather than focusing on this long-lasting plasticity, present study considered influence of respiratory control neonatal period. Sprague-Dawley rats were born and raised 60% O 2 until studied at ages (P) 4, 6–7, or 13–14 days. Ventilation metabolism normoxia (21% ) acute hypoxia (12% using head-body plethysmography respirometry, respectively. Compared with...
Microarray profiling was used to investigate gene expression in the hypoxic seizure model of acquired epilepsy rat, with aim characterizing functional pathways which are persistently activated or repressed during epileptogenesis. Hippocampal and cortical tissues were transcriptionally profiled over a one week period following an initial series seizures induced by mild hypoxia at post-natal day 10 (P10), data then analyzed focus on set enrichment analysis, approach emphasizes regulation...