A5065519116- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- PI3K/AKT/mTOR signaling in cancer
- Ion channel regulation and function
- Photoreceptor and optogenetics research
- Neurosurgical Procedures and Complications
- Phosphodiesterase function and regulation
- Traumatic Brain Injury and Neurovascular Disturbances
- Tuberous Sclerosis Complex Research
- Genetics and Neurodevelopmental Disorders
- Neonatal and fetal brain pathology
- Intracerebral and Subarachnoid Hemorrhage Research
- Receptor Mechanisms and Signaling
- Neural dynamics and brain function
Brandeis University
2017
Boston Children's Hospital
2011-2014
Massachusetts General Hospital
2005
Brigham and Women's Hospital
2005
Background and Purpose— Anticoagulation-related intracerebral hemorrhage (ICH) is often fatal, rapid reversal of anticoagulation the most appealing strategy currently available for treatment. We sought to determine whether particular emergency department (ED) interventions are effective in reversing coagulopathy improving outcome. Methods— Consecutive patients with warfarin-related ICH presenting an urban tertiary care hospital from 1998 2004 were prospectively captured a database. ED...
Early life seizures can result in chronic epilepsy, cognitive deficits and behavioral changes such as autism, conversely epilepsy is common autistic children. We hypothesized that during early brain development, could alter regulators of synaptic development underlie the interaction between autism. The mammalian Target Rapamycin (mTOR) modulates protein translation dysregulated Tuberous Sclerosis Complex, a disorder characterized by used rodent model acute hypoxia-induced neonatal results...
Abstract Objective: The most common neurological symptom of tuberous sclerosis complex (TSC) and focal cortical dysplasia (FCD) is early life refractory epilepsy. As previous studies have shown enhanced excitatory glutamatergic neurotransmission in TSC FCD brains, we hypothesized that neurons associated with these lesions may also express altered γ‐aminobutyric acid (GABA) A receptor (GABA R)‐mediated inhibition. Methods: Expression the GABA R subunits α1 α4, Na + ‐K ‐2Cl − (NKCC1) K ‐Cl...
Neocortical circuits use a family of homeostatic plasticity mechanisms to stabilize firing, including excitatory and inhibitory synaptic scaling intrinsic (Turrigiano Nelson, 2004). All three can be induced in tandem cultured rat neocortical pyramidal neurons by chronic manipulations but it is unknown whether they are coinduced the same activity-sensors signaling pathways, or under independent control. Calcium/calmodulin-dependent protein kinase type IV (CaMKIV) key sensory/effector that...
Summary Purpose To determine whether AMPA receptor ( AMPAR ) antagonist NBQX can prevent early mammalian target of rapamycin (m TOR pathway activation and long‐term sequelae following neonatal seizures in rats, including later‐life spontaneous recurrent seizures, CA 3 mossy fiber sprouting, autistic‐like social deficits. Methods L ong‐ E vans rats experienced hypoxia‐induced HS at postnatal day P )10. (20 mg/kg) was administered immediately (every 12 h × 4 doses). Twelve hours post‐ , we...