A5051276826- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Advanced Memory and Neural Computing
- Sleep and Wakefulness Research
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Cannabis and Cannabinoid Research
- Neurogenesis and neuroplasticity mechanisms
- Spatial Cognition and Navigation
- Microtubule and mitosis dynamics
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Virtual Reality Applications and Impacts
- Machine Learning in Healthcare
- Augmented Reality Applications
- Geotechnical and Geomechanical Engineering
- Granular flow and fluidized beds
- Congenital heart defects research
- Landslides and related hazards
- Speech and dialogue systems
- Attention Deficit Hyperactivity Disorder
- Molecular Communication and Nanonetworks
University of New Mexico
2021-2025
NYU Langone Health
2015-2023
Virginia Tech
2023
Neurosciences Institute
2018-2022
New York University
2015-2022
Douglas Mental Health University Institute
2012-2017
McGill University
2015-2017
Boston University
2011-2016
Excitatory control of inhibitory neurons is poorly understood due to the difficulty studying synaptic connectivity in vivo. We inferred such through analysis spike timing and validated this inference using juxtacellular optogenetic presynaptic spikes behaving mice. observed that neighboring CA1 had stronger connections superficial pyramidal cells projected more deep interneurons. Connection probability strength were skewed, with a minority highly connected hubs. Divergent led synchrony...
Cannabidiol (CBD), a non-euphoric component of cannabis, reduces seizures in multiple forms pediatric epilepsies, but the mechanism(s) anti-seizure action remain unclear. In one leading model, CBD acts at glutamatergic axon terminals, blocking pro-excitatory actions an endogenous membrane phospholipid, lysophosphatidylinositol (LPI), G-protein-coupled receptor GPR55. However, impact LPI-GPR55 signaling inhibitory synapses and epileptogenesis remains underexplored. We found that LPI...
The hippocampus is critical to the memory for sequences of events, a defining feature episodic memory. However, fundamental neuronal mechanisms underlying this capacity remain elusive. While considerable research indicates hippocampal neurons can represent locations, direct evidence coding sequential relationships among nonspatial events remains lacking. To address important issue, we recorded neural activity in CA1 as rats performed hippocampus-dependent sequence-memory task. Briefly, task...
ORIGINAL RESEARCH article Front. Aging Neurosci., 15 November 2012Sec. Neurocognitive and Behavior Volume 4 - 2012 | https://doi.org/10.3389/fnagi.2012.00028
It is commonly conceived that the cortical areas of hippocampal region are functionally divided into perirhinal cortex (PRC) and lateral entorhinal (LEC), which selectively process object information; medial (MEC), processes spatial information. Contrary to this notion, in rats performing a task demands both information processing, single neurons PRC, LEC, MEC, including those superficial deep grid, border, head direction cells have highly similar range selectivity dimensions task. By...
According to schema theory as proposed by Piaget and Bartlett, learning involves the assimilation of new memories into networks preexisting knowledge, well alteration original accommodate information. Recent evidence has shown that rats form a goal locations hippocampus plays an essential role in adding spatial schema. Here we examined nature hippocampal contributions updating monitoring firing patterns multiple CA1 neurons learned environment which there already were goals. Before learning,...
Abstract Bouts of high frequency activity known as sharp wave ripples (SPW-Rs) facilitate communication between the hippocampus and neocortex. However, paths mechanisms by which SPW-Rs broadcast their content are not well understood. Due to its anatomical positioning, granular retrosplenial cortex (gRSC) may be a bridge for this hippocampo-cortical dialogue. Using silicon probe recordings in awake, head-fixed mice, we show existence SPW-R analogues gRSC demonstrate coupling hippocampal...
There are a substantial number of studies showing that the orbitofrontal cortex links events to reward values, whereas hippocampus context in which they occur. Here we asked how contributes memory where determines values associated with events. After rats learned object–reward associations differed depending on spatial objects were presented, neuronal ensembles represented distinct value-based schemas, each composed systematic organization representations contexts and positions or nonreward....
The axon initial segment of hippocampal pyramidal cells is a key subcellular compartment for action potential generation, under GABAergic control by the "chandelier" or axo-axonic (AACs). Although AACs are only cellular source GABA targeting segment, their in vivo activity patterns and influence over cell dynamics not well understood. We achieved cell-type-specific genetic access to mice show that area CA1 synchronously activated episodes locomotion whisking during rest. Bidirectional...
Optogenetics allows for optical manipulation of neuronal activity and has been increasingly combined with intra- extra-cellular electrophysiological recordings. Genetically-identified classes neurons are optically manipulated, though the versatility optogenetics would be increased if independent control distinct neural populations could achieved on a sufficient spatial temporal resolution. We report scalable multi-site optoelectrode design that simultaneous optogenetic two spatially...
By linking the past with future, our memories define sense of identity. Because human memory engages conscious realm, its examination has historically been approached from language and introspection proceeded largely along separate parallel paths in humans other animals. Here, we first highlight achievements limitations this mind-based approach make case for a new brain-based understanding declarative focus on hippocampal physiology. Next, discuss interleaved nature common physiological...
Abstract The interpretation of neuronal spike train recordings often relies on abstract statistical models that allow for principled parameter estimation and model selection but provide only limited insights into underlying microcircuits. In contrast, mechanistic are useful to interpret microcircuit dynamics, rarely quantitatively matched experimental data due methodological challenges. Here we present analytical methods efficiently fit spiking circuit single-trial trains. Using derived...
Sharp wave-ripples (SWRs) represent synchronous discharges of hippocampal neurons and are believed to play a major role in memory consolidation. A large body evidence suggests that SWRs exclusively generated the CA3-CA2 network. In contrast, here, we provide several lines showing subiculum can function as secondary generator. with subicular origin propagate forward into entorhinal cortex well backward hippocampus proper. Our findings suggest output structures not only passively facilitating...
Temporal lobe epilepsy (TLE) is characterized by spontaneous recurrent seizures, abnormal activity between and impaired behavior. CA2 pyramidal neurons (PNs) are potentially important because inhibiting them with a chemogenetic approach reduces seizure frequency in mouse model of TLE. However, whether seizures could be stopped timing inhibition just as begins unclear. Furthermore, would reduce the cortical motor manifestations not clear. Finally, interictal EEG abnormalities TLE...
Episodic memories are temporally segmented around event boundaries that tend to coincide with moments of environmental change. During these times, the state brain should change rapidly, or reset, ensure information encountered before and after an boundary is encoded in different neuronal populations. Norepinephrine (NE) thought facilitate this network reorganization. However, it unknown whether drive NE release hippocampus and, if so, how relates changes hippocampal firing patterns. The...
Episodic memories are temporally segmented around event boundaries that tend to coincide with moments of environmental change. During these times, the state brain should change rapidly, or reset, ensure information encountered before and after an boundary is encoded in different neuronal populations. Norepinephrine (NE) thought facilitate this network reorganization. However, it unknown whether drive NE release hippocampus and, if so, how relates changes hippocampal firing patterns. The...
This work presents a fully integrated neural interface system in small form factor (1.9 g), consisting of μLED silicon optoelectrode (12 μLEDs and 32 recording sites 4-shank configuration), an Intan 32-channel chip, custom optical stimulation chip for controlling 12 μLEDs. High-resolution with approximately 68.5 nW radiant flux resolution is achieved by LED driver ASIC, which enables individual control up to 48 channels current precision 1 μA, maximum 1.024 mA, update rate >10 kHz. Recording...