A5034861323- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Memory Processes and Influences
- Neural dynamics and brain function
- Nicotinic Acetylcholine Receptors Study
Boston University
2008-2016
Boston Center for Memory
2015
University of St Andrews
2007
Abstract Rats with medial prefrontal cortex (mPFC) lesions are impaired in attentional set‐shifting, when it is required to shift a previously irrelevant perceptual dimension. The main source of noradrenergic input the mPFC from locus coeruleus via dorsal ascending bundle (DNAB). This study examined effects selective cortical noradrenaline depletion following 6‐hydroxydopamine‐induced DNAB on set‐shifting and other aspects discrimination learning performance. learned dig baited bowls, then...
Previous studies have suggested that dorsal hippocampal areas CA3 and CA1 are both involved in representing sequences of events compose unique episodes. However, it is uncertain whether the contribution restricted to spatial information, unclear encodes order per se or contributes by an active maintenance memories sequential events. Here, we developed a new behavioral task examines memory for nonspatial presented as trial-unique odor pairings. When interval between odors within studied pair...
There are a substantial number of studies showing that the orbitofrontal cortex links events to reward values, whereas hippocampus context in which they occur. Here we asked how contributes memory where determines values associated with events. After rats learned object–reward associations differed depending on spatial objects were presented, neuronal ensembles represented distinct value-based schemas, each composed systematic organization representations contexts and positions or nonreward....
There is continuing controversy about the extent to which rodent medial prefrontal cortical area (mPFC) functionally homologous dorsolateral cortex in humans and nonhuman primates. Previous studies have compared effects of mPFC lesions rats those working memory, strategy switching, temporal ordering. None, however, has examined role recognition wherein, humans, damage results a deficit source monitoring resulting impaired recollection. In present study, we memory with bilateral...