A5040016429- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Neurogenesis and neuroplasticity mechanisms
- Nicotinic Acetylcholine Receptors Study
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Advanced Fluorescence Microscopy Techniques
- Cancer and Skin Lesions
- Fire effects on ecosystems
- Spaceflight effects on biology
- Cryospheric studies and observations
- Landslides and related hazards
- Mitochondrial Function and Pathology
- Congenital heart defects research
- Functional Brain Connectivity Studies
- Hedgehog Signaling Pathway Studies
- Animal Genetics and Reproduction
- Ion channel regulation and function
- Nonmelanoma Skin Cancer Studies
Tsukuba International University
2018-2025
University of Tsukuba
2018-2025
University of Chile
2014-2022
Hospital Clínico de la Universidad de Chile
2014
Basal cell carcinoma (BCC) recurrences, especially in the facial region, represent a complex cosmetic problem. To date possibility of predicting recurrence is supported solely by histologic subtype.To evaluate relationship between BCC subtypes linked to high and low risk presence hyperechoic spots on sonography.Retrospective analysis pre-surgical ultrasound examinations primary tumours with visualization counting intra-tumoural spots. The data were then correlated corresponding...
Simultaneous imaging and manipulation of a genetically defined neuronal population can provide causal link between its activity function. Here, we designed miniaturized microscope (or 'miniscope') that allows fluorescence optogenetic at the cellular level in freely behaving animals. This miniscope has an integrated optical connector accepts any combination external light sources, allowing flexibility choice sensors manipulators. Moreover, due to simple structure use open source software, is...
Adult-born neurons (ABNs) in the dentate gyrus bestow unique cellular plasticity to mammalian brain. We recently found that activity of ABNs during sleep is necessary for memory consolidation. Here, we describe our method Ca
We developed Carignan, a real-time calcium imaging software that can automatically detect activity patterns of neurons. Carignan activate an external device when synchronized neural is detected in obtained by one-photon (1p) miniscope. Combined with optogenetics, our enables closed-loop experiments for investigating functions specific types neurons the brain. In addition to making existing pattern detection algorithms run seamlessly, we new classification module distinguishes from...
Abstract A miniaturized microscope (i.e., miniscope) enables the imaging of neuronal activity using calcium sensors while simultaneously manipulating that opsins in freely moving animals. However, many miniscopes use light-emitting diodes with broadband emission, leading to unintentional opsin stimulation by light intended solely for sensor activation (a phenomenon referred as “biological crosstalk”). To address this issue, we previously developed a miniscope including port chosen sources,...
The hippocampus is an important region responsible for memory formation. Some research evidence suggests that neurons in the discharge a sequential order to form specific activity patterns. Multiple replayed spike sequences may represent recurrence of individual's memory, and scientists refer these spatiotemporal as motifs. Identification online detection trains are studying mechanisms This work aims evaluate accuracy motifs Calcium imaging semisynthetic data where manually identified...
The mammalian hippocampal dentate gyrus is a unique memory circuit in which subset of neurons continuously generated throughout the lifespan. Previous studies have shown that neuronal population can hold fear traces (i.e., engrams) and adult-born (ABNs) support this process. However, it unclear whether ABNs themselves traces. Therefore, we analyzed ABN activity at level across conditioning paradigm. We found learning did not recruit distinct population. In sharp contrast, completely...
In this article we propose a Cloud-based platform for the detection and prediction of snow avalanches. The is based on data gathering from sensors, collection in Cloud using as an input developed Machine Learning algorithms. We discuss different phases workflow present proposed system's functionalities. also analyze validation pre-processing operations necessary before applying algorithms gathered data. integration capabilities with OpenGate cloud platform.
Prolonged changes in neural activity trigger homeostatic synaptic plasticity (HSP) allowing neuronal networks to operate within functional ranges. Cell-wide or input-specific adaptations can be induced by pharmacological genetic manipulations of activity, and sensory deprivation. Reactive caused deafferentation may partially share mechanisms with HSP. Acute hippocampal slices are a suitable model investigate relatively rapid (hours) modifications occurring after denervation explore the...
ABSTRACT Prolonged changes in neural activity trigger homeostatic synaptic plasticity (HSP) allowing neuronal networks to operate functional ranges. Cell-wide or input-specific adaptations can be induced by pharmacological genetic manipulations of activity, and sensory deprivation. Reactive caused deafferentation may partially share mechanisms with HSP. Acute hippocampal slices constitute a suitable model investigate relatively rapid (hours) pathway-specific modifications occurring after...