A5030019815- Bacteriophages and microbial interactions
- Plant Stress Responses and Tolerance
- Enzyme function and inhibition
- Chemical synthesis and alkaloids
- interferon and immune responses
- Viral Infections and Vectors
- Plant Molecular Biology Research
- Microbial Metabolites in Food Biotechnology
- Genomics and Phylogenetic Studies
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Virus-based gene therapy research
- Microbial Community Ecology and Physiology
- Viral gastroenteritis research and epidemiology
- Photosynthetic Processes and Mechanisms
- Cancer-related molecular mechanisms research
- Bacillus and Francisella bacterial research
- Helicobacter pylori-related gastroenterology studies
- Plant Gene Expression Analysis
- Plant nutrient uptake and metabolism
- RNA and protein synthesis mechanisms
- Silicon Effects in Agriculture
- Antibiotic Resistance in Bacteria
- PI3K/AKT/mTOR signaling in cancer
Fujian Normal University
2018-2025
Trend Micro (Japan)
2024
Southern University of Science and Technology
2020-2023
Fujian Institute of Oceanography
2022
Wuhan Institute of Virology
2018-2021
Chinese Academy of Sciences
2018-2021
University of Chinese Academy of Sciences
2019-2021
Fujian Institute of Microbiology
2019
Huazhong Agricultural University
2008-2017
Instituto Politécnico Nacional
2011-2017
Evidence supports using antiplatelet therapy in patients with acute ischemic stroke. However, neurological deterioration remains common under the currently recommended regimen, leading to poor clinical outcomes.
The influence of Toll‑like receptor (TLR)4/myeloid differentiation factor (MyD)88 signaling on the invasion and metastasis cancer cells has been previously reported. purpose present study was to determine role TLR4/MyD88 in breast cell migration invasion, discover novel therapeutic targets for treatment. TLR4, MyD88 high mobility group box 1 (HMGB1) mRNA expression levels were assessed highly invasive human MDA‑MB‑231 cells, with a low rate (MCF‑7) normal MDA‑Kb2 mammary gland by reverse...
DNA methylation abnormality is closely related to tumor occurrence and development. Chemical inhibitors targeting methyltransferase (DNMTis) have been used in treating cancer. However, the impact of DNMTis on antitumor immunity has not well elucidated. In this study, we show that zebularine (a demethylating agent) treatment cancer cells led increased levels interferon response a cyclic guanosine monophosphate-AMP (cGAMP) synthase (cGAS)- stimulator genes (STING)-dependent manner. This also...
Summary Brassinosteroids (BRs) are a group of plant‐specific steroid hormones, which induces the rapid nuclear localization positive transcriptional factors BRASSINAZOLE RESISTANT1/2 (BZR1/2). However, mechanisms underlying regulation nucleocytoplasmic shuttling BZR1 remain to be fully elucidated. In this study, we show that scaffold protein Receptor for Activated C Kinase 1 (RACK1) from Arabidopsis is involved in BR signaling cascades through mediating BZR1, tightly retained cytosol by...
Plants have adopted versatile scaffold proteins to facilitate the crosstalk between multiple signaling pathways. Leaf senescence is a well-programmed developmental stage that coordinated by various external and internal signals. However, functions of plant in response signals are not well understood. Here, we report protein RACK1A (RECEPTOR FOR ACTIVATED C KINASE 1A) participates leaf mediated ethylene via coordination EIN3-miR164-ORE1 transcriptional regulatory cascade. novel positive...
DNA transfection is often the bottleneck of research and gene therapy practices. To explore mechanism regulating transgene expression, we investigated role cGAS-STING signaling pathway, which induces type-I interferons in response to DNA. We confirmed that deletion cGAS enhances expression at protein level by ~2- 3-fold. This enhancement inversely correlated with interferon stimulated genes (ISGs), suppress transfected mRNA level. Mechanistically, activates pathway OAS family proteins,...
Abstract Background Saussurea involucrata survives in extreme arctic conditions and is very cold-resistant. This species grows rocky, mountainous areas with elevations of 2400–4100 m, which are snow-covered year-round subject to freezing temperatures. S. ’s ability survive an low-temperature environment suggests that it has particularly high photosynthetic efficiency, providing a magnificent model, rich gene pool, for the analysis plant cold stress response. Fructose-1, 6-bisphosphate...
Potentiation of traditional antibiotics is significance for combating antibiotic-resistant bacteria that have become a severe threat to human and animal health. Here, we report 1 min co-treatment with n-butanol greatly specifically enhances the bactericidal action aminoglycosides by 5 orders magnitude against stationary-phase Staphylococcus aureus cells, n-propanol isobutanol showing less potency. This combined treatment also rapidly kills various S. persisters, methicillin-resistant (MRSA)...
Porcine epidemic diarrhea virus (PEDV) has caused significant losses in the pork industry, but mechanism of PEDV infection is still unclear. On basis our RNA-Seq data and due to potential role sialic acid as a coreceptor, we investigated function acid-binding Ig-like lectin 15 (Siglec-15) determine its receptor infection. We found that Siglec-15 enhances by promoting viral adsorption host cells. Coimmunoprecipitation immunofluorescence assays revealed binds S1 subunit M protein PEDV....
Ginger rhizome rot disease, caused by the pathogen
Pyrroloquinoline quinone (PQQ) has a variety of biological functions. However, rare attention been paid to its effects on exercise-induced damage. Here, we assessed the potential protective PQQ against fatigue and oxidative damage caused by repeated exhaustive exercise, studied underlying mechanism. The models for were established, parameters measured, including time exhaustion (TTE), biochemical indicators, expression nuclear factor kappa B (NF-κB) inflammatory cytokines so on. Besides,...
Purpose: Recent studies indicate that pregnancy upregulated non-ubiquitous calmodulin kinase (PNCK) is significantly up-regulated in breast and renal carcinomas. However, the expression profile its biological relevance of PNCK nasopharyngeal carcinoma (NPC) have not been elucidated. Methods: The level was detected specimens NPC (n=10) normal tissues by real-time PCR immunohistochemistry. Celigo Cell Counting MTT assay were used to measure cell viability. Apoptosis flow cytometric analysis...
Improving the efficacy of existing antibiotics is significant for combatting antibiotic resistance that poses a major threat to human health. Carbonyl cyanide m-chlorophenylhydrazine (CCCP), well-known protonophore dissipating proton motive force (PMF), has been widely used block PMF-dependent uptake aminoglycoside and thus suppress lethality. Here, we report CCCP its functional analog FCCP, but not other types protonophores, unprecedently potentiate aminoglycosides (e.g., tobramycin...
Due to the great diversity in protein expression productivity, a customized transient gene (TGE) method was used present study optimize of three antibodies. Several factors, including host cells, temperature, valproic acid (VPA) treatment, various vectors, and additives were optimized independently then combined form TGE protocol for each antibody. In event, conditions antibodies different from other. Compared with CHO-S cells by pCDNA3.1 vector, productivities 8C11 cAb, 37 hAb, 10F7 cAb...
Phages, the parasites of bacteria, are considered as a new kind antimicrobial agent due to their ability lyse pathogenic bacteria. Due increase available phage isolates, newly isolated showed increasing genomic similarities with previously phages. In this study, novel vB_BthS_BMBphi, infecting Bacillus thuringiensis strain BMB171, is and characterized together its endolysin. This first tadpole-like strains. Genomic analysis shows that genome dissimilar all those phages, only exhibiting low...
Bacillus thuringiensis (Bt) is widely used in producing biological insecticides. Phage contaminations during Bt fermentation can cause severe losses of yields. Lots strategies have been engaged to control extrinsic phage contamination fermentation, but their effectiveness low. In this study, the candidate endogenous prophages (prophages) 61 chromosomes that had deposited GenBank database were analyzed. The results revealed all contained prophage regions, and 398 regions predicted, including...
Cyclocarya paliurus, a well-known nutrient and beverage plant, is under development for use in functional health care products best natural organic foods. We hypothesis that the composition metabolic accumulation of hypoglycemic metabolites exhibit significant differences depending on harvest time. Therefore, it great significance to establish time C. paliurus leaves further healthy teas other products. However, detail compositions molecular mechanisms nutrients biosynthesis during different...
Due to the increasing spread of multidrug-resistant (MDR) bacteria, phage therapy is considered one most promising methods for addressing MDR bacteria. Escherichia coli lives symbiotically in intestines humans and some animals, strains are beneficial terms maintaining a healthy digestive tract. However, E. can cause serious zoonotic diseases, including diarrhea, pneumonia, urinary tract infections, hemolytic uremic syndrome. In this study, we characterized newly isolated Myoviridae phage,...
Abstract The pandemics induced by emerging SARS‐CoV‐2 variants and monkeypox virus infection have triggered the urgent need for broad‐spectrum vaccines. Except “super” antigen designs, pattern recognition receptor (PRR) agonist‐based adjuvants might blaze a new trail, through enhancing immune response of conserved epitopes shared among cross‐protection. Ideal with proper adjustments could be conveniently applied to different antigens types in pandemics. However, general strategies modulating...