Heng Zhao

ORCID: 0000-0003-2938-5613
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Mycorrhizal Fungi and Plant Interactions
  • Plant Pathogens and Fungal Diseases
  • Hydrocarbon exploration and reservoir analysis
  • Fungal Biology and Applications
  • Methane Hydrates and Related Phenomena
  • Lichen and fungal ecology
  • Mass Spectrometry Techniques and Applications
  • Yeasts and Rust Fungi Studies
  • Plant and Fungal Species Descriptions
  • Bryophyte Studies and Records
  • Botany and Plant Ecology Studies
  • Microbial Natural Products and Biosynthesis
  • Advanced Proteomics Techniques and Applications
  • Virology and Viral Diseases
  • Microplastics and Plastic Pollution
  • Collembola Taxonomy and Ecology Studies
  • Infectious Diseases and Mycology
  • Virus-based gene therapy research
  • Coal Properties and Utilization
  • interferon and immune responses
  • Atmospheric and Environmental Gas Dynamics
  • Geological and Geophysical Studies
  • Inflammasome and immune disorders
  • Viral Infections and Vectors
  • Time Series Analysis and Forecasting

Chinese Academy of Sciences
2003-2025

China National Administration of Coal Geology
2018-2025

Beijing Forestry University
2012-2025

Dalian Institute of Chemical Physics
2022-2025

Shenzhen Technology University
2025

Anhui University of Technology
2025

Fujian Normal University
2021-2024

Shandong Normal University
2011-2024

Institute of Microbiology
2003-2023

Chengdu University of Technology
2023

Polypores play a crucial role in energy recycling and forest regeneration ecosystems. The majority of them are wood degraders; some pathogens others ectomycorrhizal symbionts. basidiocarps provide food shelter for many organisms, mostly invertebrates, but also vertebrates, as well medicine humans. Despite extensive research on the species diversity phylogenetic relationships polypores recent years, there remains lack comprehensive understanding their distribution patterns composition at...

10.1016/j.fecs.2024.100200 article EN cc-by-nc-nd Forest Ecosystems 2024-01-01

DNA methylation abnormality is closely related to tumor occurrence and development. Chemical inhibitors targeting methyltransferase (DNMTis) have been used in treating cancer. However, the impact of DNMTis on antitumor immunity has not well elucidated. In this study, we show that zebularine (a demethylating agent) treatment cancer cells led increased levels interferon response a cyclic guanosine monophosphate-AMP (cGAMP) synthase (cGAS)- stimulator genes (STING)-dependent manner. This also...

10.1016/j.ymthe.2021.02.005 article EN cc-by-nc-nd Molecular Therapy 2021-02-09

Directly probing the heterogeneous conformations of intracellular proteins within their native cellular environment remains a significant challenge in mass spectrometry (MS). Here, we establish an in-cell MS and ultraviolet photodissociation (UVPD) strategy that directly ejects from living cells into spectrometer, followed by 193 nm UVPD for structural analysis. Applying this approach to calmodulin (CaM), reveal it adopts more extended compared with purified samples vitro, highlighting...

10.1021/jacs.4c16376 article EN Journal of the American Chemical Society 2025-01-30

To elucidate the genomic traits of ecological diversification in Hymenochaetales, we sequenced 15 new genomes, with attention to ectomycorrhizal (EcM) Coltricia species. Together published data, 32 including 31 Hymenochaetales and one outgroup, were comparatively analyzed total. Compared those parasitic saprophytic members, EcM species have significantly reduced number plant cell wall degrading enzyme genes, expanded transposable elements, genome sizes, small secreted proteins, proteases....

10.1093/gbe/evad136 article EN cc-by Genome Biology and Evolution 2023-07-27

How mutations impact protein stability and structure dynamics is crucial for understanding the pathological process rational drug design. Herein, we establish a time-resolved native mass spectrometry (TR-nMS) platform via rapid-mixing capillary apparatus monitoring acid-initiated unfolding process. The molecular details in are further profiled by 193 nm ultraviolet photodissociation (UVPD) analysis of structure-informative photofragments. Compared with wild-type dihydrofolate reductase...

10.1021/jacs.4c00316 article EN Journal of the American Chemical Society 2024-03-20

Newcastle disease virus (NDV) was examined for its suitability as a vector the expression and delivery of foreign genes vaccination gene therapy. A reporter encoding human secreted alkaline phosphatase (SEAP) inserted an additional transcription unit at four different positions in NDV genome, between NP P, M F, HN L behind gene. Eight infectious recombinant (rNDV) viruses, non-virulent strain NDFL virulent derivative NDFLtag, were generated by reverse genetics. SEAP levels, replication...

10.1099/vir.0.18884-0 article EN Journal of General Virology 2003-03-24

The marine carbonates of the Tarim Basin are taken to study relationship between source rock and oil gas reservoirs discuss possibility mechanisms mature low-TOC (less than 0.5%) being rock. By studying matching rocks in hydrocarbon Tahe oilfield analyzing hydrocarbon-generating organism combination its correlation with geochemical characteristics reservoirs, this established a method evaluate generation substance carbonate rocks. It is concluded that crude not derived from muddy rocks, but...

10.1016/s1876-3804(17)30020-4 article EN cc-by-nc-nd Petroleum Exploration and Development 2017-02-01

Phylogenetic and morphological analyses on Ceriporia other related genera in Irpicaceae were carried out.Ceriporia, Gloeoporus, Meruliopsis characterised as resupinate, effusedreflexed or pileate polypores with poroid smooth hymenophore, a monomitic hyphal structure, crystals, an oily substance are contained the Irpicaceae.Ceriporia phylogenetically sister genera.They share resupinate to rarely effused-reflexed basidiomata white, buff brightly colored structure simple septa generative...

10.5943/mycosphere/14/1/19 article EN cc-by-nc-sa Mycosphere 2023-01-01

Phagocyte NADPH oxidase plays a key role in pathogen clearance via reactive oxygen species (ROS) production. Defects function result chronic granulomatous disease with hallmark recurrent microbial infections and inflammation. The oxidase's the adaptive immune response is not well understood. Class II presentation of cytoplasmic exogenous Ag to CD4(+) T cells was impaired human B reduced p40(phox) subunit expression. Naturally arising mutations, which compromise patient, also perturbed class...

10.4049/jimmunol.1103080 article EN The Journal of Immunology 2012-09-15

Hypersensitive C-reaction protein (hsCRP) may be a risk factor for cognitive impairment resulting from Alzheimer's disease (AD), stroke, and vascular dementia. This study explored the correlation of peripheral blood hsCRP level with decline due to high altitude exposure. The was conducted on 100 male military participants who had never been altitude. Cerebral oxygen saturation monitoring, event related potentials (P300, N200) detection, neurocognitive assessment performed total hsCRP,...

10.1371/journal.pone.0146290 article EN cc-by PLoS ONE 2016-01-05

Phylogenetic analyses inferred from the nuc rDNA ITS1-5.8S-ITS2 (ITS) data set and combined 2-locus [5.8S + 28S (nLSU)] of taxa Trechisporales around world show that Sistotremastrum family forms a monophyletic lineage within Trechisporales. Bayesian evolutionary divergence time on two sets 5.8S nLSU sequences indicate an ancient Hydnodontaceae during Triassic period (224.25 Mya). is characterized by resupinate thin basidiomata, smooth, verruculose, or odontoid-semiporoid hymenophore,...

10.3389/fmicb.2022.818358 article EN cc-by Frontiers in Microbiology 2022-04-25

is distributed worldwide and primarily isolated from soil, feces, decaying plants. The genus was initially classified into Absidiaceae then Mucoraceae, currently belongs to Cunninghamellaceae further divided

10.3897/mycokeys.110.129120 article EN cc-by MycoKeys 2024-11-20

The genomic region encompassing the L protein gene and a small open reading frame (ORF 6) of Rice yellow stunt virus (RYSV) has been sequenced, thus completing nucleotide sequence RYSV genome. genome organization is unique in rhabdoviruses because it contains two additional genes when compared to basic order family Rhabdoviridae: Phylogenetic analysis revealed that amino acid most closely related Sonchus yellows net virus, another nucleorhabdovirus. However, acidic N-terminal domain distinct...

10.1099/vir.0.19195-0 article EN Journal of General Virology 2003-07-16

The species diversity of early-diverging fungi has long lagged behind that higher fungi, posing a significant obstacle to our comprehensive understanding the fungal kingdom. Our ongoing research endeavors aim address this gap by exploring in China. In study, we describe three novel within Backusella , namely B. elliptica sp. nov. fujianensis and variispora based on phylogenetic morphological analyses. analysis ITS (internal transcribed spacer), LSU (large subunit ribosomal RNA gene), RPB1...

10.3897/mycokeys.109.126029 article EN cc-by MycoKeys 2024-10-14
Coming Soon ...