A5000540211- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Immune cells in cancer
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neonatal and fetal brain pathology
- Heat shock proteins research
- Acute Ischemic Stroke Management
- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- Circadian rhythm and melatonin
- Endoplasmic Reticulum Stress and Disease
- S100 Proteins and Annexins
- Biochemical effects in animals
- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Nuclear Receptors and Signaling
- Genomics, phytochemicals, and oxidative stress
- Photoreceptor and optogenetics research
- Tryptophan and brain disorders
- Genetics, Aging, and Longevity in Model Organisms
- Sleep and Wakefulness Research
- Cardiac Arrest and Resuscitation
Duquesne University
2015-2024
University of Pittsburgh
2010-2021
Mylan (United States)
2011-2020
Fudan University
2012-2016
State Key Laboratory of Medical Neurobiology
2012-2016
Geriatric Research Education and Clinical Center
2012-2016
Capital Medical University
2013-2016
Nanjing University
2015
Third Affiliated Hospital of Sun Yat-sen University
2015
Sun Yat-sen University
2015
Background and Purpose— Mononuclear phagocytes are highly plastic cells that assume diverse phenotypes in response to microenvironmental signals. The phenotype-specific roles of microglia/macrophages ischemic brain injury poorly understood. A comprehensive characterization microglia/macrophage polarization after ischemia may advance our knowledge poststroke damage/recovery. Methods— Focal transient cerebral was induced mice for 60 minutes; animals were euthanized at 1 14 days reperfusion....
Mononuclear phagocytes are a population of multi-phenotypic cells and have dual roles in brain destruction/reconstruction. The phenotype-specific microglia/macrophages traumatic injury (TBI) are, however, poorly characterized. In the present study, TBI was induced mice by controlled cortical impact (CCI) animals were killed at 1 to 14 days post injury. Real-time polymerase chain reaction (RT–PCR) immunofluorescence staining for M1 M2 markers performed characterize phenotypic changes both...
Background and Purpose— Interleukin-4 (IL-4) is a unique cytokine that may contribute to brain repair by regulating microglia/macrophage functions. Thus, we examined the effect of IL-4 on long-term recovery polarization in 2 well-established stroke models. Methods— Transient middle cerebral artery occlusion or permanent distal was induced wild-type knockout C57/BL6 mice. In separate cohort animals, (60 ng/d for 7 days) vehicle infused into cerebroventricle after transient occlusion....
Abstract The mechanism and long-term consequences of early blood–brain barrier (BBB) disruption after cerebral ischaemic/reperfusion (I/R) injury are poorly understood. Here we discover that I/R induces subtle BBB leakage within 30–60 min, likely independent gelatinase B/MMP-9 activities. is caused by the activation ROCK/MLC signalling, persistent actin polymerization disassembly junctional proteins microvascular endothelial cells (ECs). Furthermore, EC alterations facilitate subsequent...
Significance Moderate or severe traumatic brain injury (TBI) damages white matter, thereby contributing to long-term neurological deficits. Currently, there are no satisfactory therapies mitigate this matter (WMI). Here we show that inhibition of histone deacetylases (HDACs) exerts robust structural and functional protection in a murine model TBI/WMI by polarizing microglia/macrophages toward the beneficial M2 phenotype. HDAC shifted microglia/macrophage phenotype up-regulating glycogen...
ST2, a member of the interleukin (IL) 1 receptor family, and its ligand IL-33 play critical roles in immune regulation inflammatory responses. This study explores endogenous IL-33/ST2 signaling ischemic brain injury elucidates underlying mechanisms action. The expression rapidly increased oligodendrocytes astrocytes after 60 min transient middle cerebral artery occlusion (tMCAO). ST2 deficiency exacerbated infarction 3 d tMCAO as well distal permanent MCAO. also aggravated neurological...
The suprachiasmatic nucleus (SCN) temporally organizes behavior in part by sustaining arousal during the wake period of sleep/wake cycle to consolidate adaptive waking behavior. In this study, we demonstrate direct projections from SCN, both rat and human brains, perikarya proximal dendrites two groups posterior hypothalamic neurons with axonal that suggest they are important regulation arousal, one producing hypocretins (HCT) other melanin-concentrating hormone (MCH). addition, HCT...
Abstract The mammalian circadian pacemaker, the hypothalamic suprachiasmatic nucleus (SCN), has two subdivisions. core is located above optic chiasm, receives primary and secondary visual afferents, contains neurons producing vasoactive intestinal polypeptide gastrin‐releasing peptide. shell largely surrounds core, input from nonvisual sources arginine vasopressin calretinin. In this study, we tested hypothesis that SCN efferent projections are topographically organized with respect to...
Ischemic stroke is a debilitating clinical disorder that affects millions of people, yet lacks effective neuroprotective treatments. Fish oil known to exert beneficial effects against cerebral ischemia. However, the underlying protective mechanisms are not fully understood. The present study tests hypothesis omega-3 polyunsaturated fatty acids (n-3 PUFAs) attenuate ischemic neuronal injury by activating nuclear factor E2-related 2 (Nrf2) and upregulating heme oxygenase-1 (HO-1) in both vitro...