A5101778776- Viral Infections and Vectors
- Renal Diseases and Glomerulopathies
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Adrenal and Paraganglionic Tumors
- Pancreatic and Hepatic Oncology Research
- Hormonal Regulation and Hypertension
- Reproductive System and Pregnancy
- Mosquito-borne diseases and control
- Cancer Immunotherapy and Biomarkers
- SARS-CoV-2 and COVID-19 Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune Cell Function and Interaction
- Neurological Disease Mechanisms and Treatments
- Pancreatitis Pathology and Treatment
- Fire effects on ecosystems
- Chronic Kidney Disease and Diabetes
- Viral Infections and Outbreaks Research
- Genetic and Kidney Cyst Diseases
- Reproductive Physiology in Livestock
- Adipokines, Inflammation, and Metabolic Diseases
- Neonatal and fetal brain pathology
- Colorectal Cancer Screening and Detection
- Endometriosis Research and Treatment
- Immunotherapy and Immune Responses
Huashan Hospital
2022-2025
Fudan University
2014-2025
Beijing Forestry University
2025
University of Chinese Academy of Sciences
2016-2024
Chinese Academy of Sciences
2016-2024
Hainan General Hospital
2021-2024
Institute of Microbiology
2024
Wuhan Institute of Virology
2016-2023
Qilu Hospital of Shandong University
2021-2023
Shandong University
2021-2023
Efferocytosis, or phagocytic clearance of dead/dying cells by brain-resident microglia and/or infiltrating macrophages, is instrumental for inflammation resolution and restoration brain homeostasis after stroke. Here, we identify the signal transducer activator transcription 6/arginase1 (STAT6/Arg1) signaling axis as a potentially novel mechanism that orchestrates microglia/macrophage responses in ischemic brain. Activation STAT6 was observed microglia/macrophages territory mouse model...
Diabetic kidney disease (DKD) is the leading cause of end-stage renal diseases. DKD does not have efficacious treatment. The cGAS-STING pathway activated in podocytes at early stage dysfunction, which associated with activation STING downstream effectors TBK1 and NF-κB but IRF3. Lipotoxicity induces mitochondrial damage mtDNA leakage to cytosol through Bcl-2 X protein (BAX) podocytes. BAX-mediated cytosolic can activate absence lipotoxicity sufficient podocyte injury. Depletion mtDNA,...
The Bunyavirales is one of the largest groups RNA viruses, which encompasses many strains that are highly pathogenic to animals and humans. Severe fever with thrombocytopenia syndrome virus (SFTSV) an emerging tick-borne bunyavirus causes severe disease in humans, a high fatality rate up 30%. To date, entry process infection remains obscure. Here, using quantum dot (QD)-based single-particle tracking multicolor imaging, dynamic molecular SFTSV penetration systematically dissected. results...
Endometritis is an inflammatory disease of the uterus caused by bacterial infection, and it affects both human animal health. This study aims to investigate protective effects molecular mechanisms probiotics such as Clostridium tyrobutyricum (C. tyrobutyricum) on Staphylococcus aureus (S. aureus)-induced endometritis. The results showed that S. infection significantly induced pathological damage uterus, increased production pro-inflammatory cytokines, TNF-α IL-1β, attenuated expression tight...
The recent outbreak of novel coronavirus pneumonia (COVID-19) caused by a new has posed great threat to public health. Identifying safe and effective antivirals is urgent demand cure the huge number patients. Virus-encoded proteases are considered potential drug targets. human immunodeficiency virus protease inhibitors (lopinavir/ritonavir) been recommended in global Solidarity Trial March launched World Health Organization. However, there currently no experimental evidence support or...
Abstract Background Brain microglia and macrophages (Mi/MΦ) can shift to a harmful or advantageous phenotype following an ischemic stroke. Identification of key molecules that regulate the transformation resting Mi/MΦ could aid in development innovative therapies for The transcription factor signal transducer activator transduction 1 (STAT1) has been found contribute acute neuronal death (in first 24 h) stroke, but its effects on influence long-term stroke outcomes have yet be determined....
The lipid-lowering properties of lotus leaf are primarily attributed to the active alkaloid, nuciferine. In this study, role and underlying mechanisms nuciferine in lipid metabolism regulation from a biomechanical perspective were investigated using molecular docking vitro vivo studies, employing HepG2 cells Caenorhabditis elegans (C. elegans) as experimental models. results indicated that exhibited significant binding affinity targets Sterol Regulatory Element-Binding Protein-1c (SREBP-1c)...
Background: Although there have been reports of relapse or worsening membranous nephropathy after receiving vaccines against coronavirus disease 2019 (COVID-19), the causal relationship association between them has not established. This study aimed to investigate occurrence following inactivated COVID-19 vaccination. Methods: Patients who had diagnosed with before their first dose vaccination, March 1, 2021, for unvaccinated patients, were included in study. All patients monitored at...
Endometritis, the inflammation of endometrial lining caused by bacterial pathogens, is associated with reproductive failure.
Yap is required for ovarian follicle and early embryo development, but little information available regarding its physiological significance in decidualization.Here we determine the effects of YAP on decidualization, mitochondrial function, cell apoptosis DNA damage, explore interplay with Bmp2, Rrm2, GSH ROS.The results exhibited that was abundant decidual cells inactivation impaired proliferation differentiation stromal along deferral G1/S phase transition, indicating importance...
Phloretin is a natural dihydrochalcone with variety of biological activities. Its potential in modulating lipid metabolism vitro and vivo HepG2 C. elegans was investigated in...
Isthmin-1 (Ism-1), as a novel adipokine, plays role in glucose homeostasis and lipid metabolism. However, the relationship between Ism-1 type 2 diabetes mellitus (T2DM) remains unclear. This study aims to investigate association of serum levels with albuminuria insulin resistance patients T2DM preserved renal function.A total 150 were recruited. The presence was evaluated by urinary albumin:creatinine ratio (UACR) first morning urine sample. Serum tested ELISA. Homeostasis model assessments...
Summary Aims Neonatal hypoxia–ischemia (H/I) results in gray and white matter injury, characterized by neuronal loss, failure of neural network formation, retarded myelin abnormal accumulation oligodendrocyte progenitor cells (OPCs). These changes lead to severe neurological deficits mortality. Sublethal hypoxic preconditioning (HPC) can protect the developing brain against H/I. However, limited evidence is available concerning its effect on injury. Methods In this study, P6 neonatal...
Isthmin-1 (Ism-1) is a newly identified insulin-like adipokine that increases glucose uptake by adipocytes and inhibits hepatic lipid synthesis. Recent studies have shown Ism-1 can improve the metabolic disorders associated with type 2 diabetes mellitus (T2DM) metabolism. The classic function of high-density lipoprotein cholesterol (HDL-C) to transport from extra-hepatic tissues liver for In contrast, metabolism inflammation are leading causes atherosclerosis (As). Atherosclerosis often...
Abstract Accumulating evidence indicates that the extracellular matrix (ECM) is not only a consequence of fibrosis, but also contributes to progression by creating profibrotic microenvironment. Tenascin-C (TNC) an ECM glycoprotein contains multiple functional domains. We showed following kidney injury, TNC was markedly induced in fibrotic areas from both mouse models and humans with diseases. Genetically deletion mice significantly attenuated unilateral ureteral obstruction-induced fibrosis....
ABSTRACT Background Rituximab has been shown effective in patients with primary membranous nephropathy refractory to glucocorticoids plus cyclophosphamide (GC + CTX) or calcineurin inhibitors (CNIs), but the response rates remain limited. Compared rituximab, obinutuzumab is a humanized anti-CD20 monoclonal antibody greater B-cell depletion capacity. This study was performed investigate effectiveness of compared rituximab treating nephropathy. Methods A retrospective conducted at Huashan...