A5075602421- Trypanosoma species research and implications
- Lysosomal Storage Disorders Research
- Pancreatic function and diabetes
- Biochemical and Molecular Research
- Functional Brain Connectivity Studies
- Calcium signaling and nucleotide metabolism
- Advanced Neuroimaging Techniques and Applications
- Microtubule and mitosis dynamics
- Research on Leishmaniasis Studies
- Metabolism, Diabetes, and Cancer
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Advancements in Solid Oxide Fuel Cells
- Autophagy in Disease and Therapy
- Angiogenesis and VEGF in Cancer
- Ferroptosis and cancer prognosis
- Electrocatalysts for Energy Conversion
- RNA modifications and cancer
- Neural dynamics and brain function
- Insect symbiosis and bacterial influences
- Fuel Cells and Related Materials
- Cell Adhesion Molecules Research
- Bipolar Disorder and Treatment
- Metal-Organic Frameworks: Synthesis and Applications
- Academic integrity and plagiarism
West Anhui University
2023-2025
The University of Texas Health Science Center at Houston
2013-2025
National Institute on Drug Abuse
2024
National Institutes of Health
2024
Johns Hopkins University
2024
Beijing Normal University
2024
Trinity College Dublin
2023-2024
Anhui Medical University
2022-2024
Qilu Hospital of Shandong University
2019-2024
Shanghai Sixth People's Hospital
2024
Abstract Background Diabetes and obesity are associated with muscle atrophy that reduces life quality lacks effective treatment. Mesenchymal stromal cell (MSC)‐based therapy can ameliorate high fat‐diet (HFD) immobilization (IM)‐induced in mice. However, the effect of MSCs on type 2 diabetes mellitus (T2DM) potential mechanism is unclear. Here, we evaluated efficacy explored molecular mechanisms human umbilical cord (hucMSCs) hucMSC‐derived exosomes (MSC‐EXO) diabetes‐ obesity‐induced...
Morphogenesis of a vascular network requires dynamic vessel growth and regression. To investigate the cellular mechanism underlying this process, we deleted focal adhesion kinase (FAK), key signaling mediator, in endothelial cells (ECs) using Tie2-Cre mice. Targeted FAK depletion occurred efficiently early development, where mutants exhibited distinctive irregular vasculature, resulting hemorrhage lethality between embryonic day (e) 10.5 11.5. Capillaries intercapillary spaces yolk sacs were...
β1 integrin (encoded by Itgb1) is established as a regulator of angiogenesis based upon the phenotypes complete knockouts heterodimer partners or ligands and antibody inhibition studies in mice. Its direct function endothelial cells (ECs) vivo has not been determined because Itgb1-/- embryos die before vascular development. Excision Itgb1 from ECs subset hematopoietic cells, using Tie2-Cre, resulted abnormal development embryonic day(e) 8.5 lethality e10.5. Tie1-Cre mediated more restricted...
Major depressive disorder (MDD) and bipolar (BD) are common severe affective diseases. Although previous neuroimaging studies have investigated brain abnormalities in MDD or BD, the structural functional differences between these two disorders remain unclear. In this study, we adopted a multimodal approach, combining voxel-based morphometry (VBM) connectivity (FC), to study distinct alterations unmedicated BD patients. The VBM analysis revealed that both patients showed decreased gray matter...
Abstract Background Mesenchymal stem cell (MSC)-based therapy is currently considered to be an effective treatment strategy for diabetes and hepatic disorders, such as liver cirrhosis non-alcoholic fatty disease. Exosomes are important mediators of cellular connections, increasing evidence has suggested that exosomes derived from MSCs may used direct therapeutic agents; their mechanisms action, however, remain largely unclear. Here, we evaluated the efficacy molecular human umbilical cord...
Background. More and more studies focus on the relationship between gastrointestinal microbiome type 2 diabetes, but few of them have actually explored enterotypes diabetes. Materials Methods. We enrolled 134 patients with diabetes 37 nondiabetic controls. The anthropometric clinical indices each subject were measured. Fecal samples also collected processed for 16S rDNA sequencing. Multiple logistic regression analysis was used to determine associations linear explore lipopolysaccharide...
Diabetic kidney disease (DKD) is the leading cause of end-stage renal diseases. DKD does not have efficacious treatment. The cGAS-STING pathway activated in podocytes at early stage dysfunction, which associated with activation STING downstream effectors TBK1 and NF-κB but IRF3. Lipotoxicity induces mitochondrial damage mtDNA leakage to cytosol through Bcl-2 X protein (BAX) podocytes. BAX-mediated cytosolic can activate absence lipotoxicity sufficient podocyte injury. Depletion mtDNA,...
Metabolic dysfunction-associated fatty liver disease (MAFLD) is frequently linked to type 2 diabetes mellitus (T2DM), and both conditions exacerbate the progression of other. However, there currently no standardized treatment or drug for MAFLD. In this study, A MAFLD animal model through a high-fat diet (HFD) along with administration streptozotocin (STZ), palmitic acid (PA)-induced AML12 cells were treated by puerarin. The objective study was assess therapeutic effect puerarin, flavonoid...
A mutual coordination of size between developing arteries and veins is essential for establishing proper connections these vessels and, ultimately, a functional vasculature; however, the cellular molecular regulation this parity not understood. Here, we demonstrate that dorsal aorta cardinal vein reciprocally balanced. Mouse embryos carrying gain-of-function Notch alleles show enlarged aortae underdeveloped veins, whereas those with loss-of-function mutations small large veins. does affect...
Abstract Background Bipolar disorder (BD) has been associated with altered brain structural and functional connectivity. However, little is known regarding alterations of the connectome in BD. The present study aimed to use diffusion-tensor imaging (DTI) graph theory approaches investigate rich club organization white matter Methods Forty-two patients unmedicated BD depression 59 age-, sex- handedness-matched healthy control participants underwent DTI. whole-brain was constructed by a...
Cognitive dysfunction often occurs in diabetes mellitus patients. This study aimed to investigate the efficacy of melatonin (MLT) improving diabetes-associated cognitive decline and underlying mechanism involved. Type 2 diabetic mice palmitic acid (PA)-stimulated BV-2 cells were treated by MLT, potential mechanisms among cognition, autophagy explored. The results showed that type obvious learning memory impairments Morris water maze test compared with normal controls, which could be...
The eyes are our windows to the brain. There differences in brain activity between people who have their closed (EC) and open (EO). Previous studies focused on functional properties these conditions based an assumption that is a static phenomenon. However, dynamic nature of different still unclear. In this study, we collected resting-state fMRI data from 21 healthy subjects EC EO conditions. Using sliding time window approach k-means clustering algorithm, calculated temporal connectivity...
Type 2 diabetes mellitus (T2DM) is an age-related disease characterized by impaired pancreatic β cell function and insulin resistance. Recent studies have shown that the accumulation of senescent cells under metabolic stress conditions leads to progression T2DM, while senolysis can improve prognosis. However, specific mechanism senescence still unclear. In this study, we found increased load in both older mice obese induced high-fat diet (HFD) (DIO mice) was accompanied activation Cyclic...
Diabetic kidney disease (DKD) is well-acknowledged as one of the most common complications in diabetes mellitus. Recent studies have demonstrated promising role mesenchymal stem cell-derived exosomes (MSC-exos) a cell-free treatment strategy for DKD. The present study sought to investigate therapeutic potential and underlying mechanisms MSC-exos authentication was validated by western blot, transmission electron microscope (TEM), nanosight tracking analysis (NTA). Apoptosis detected TUNEL...
The c-myc proto-oncogene, which is crucial for the progression of many human cancers, has been implicated in key cellular processes diverse cell types, including endothelial cells that line blood vessels and are critical angiogenesis. de novo differentiation known as vasculogenesis, whereas growth new from pre-existing To ascertain function vascular development, we deleted selected lineages. Embryos lacking hematopoietic lineages phenocopied those entire embryo proper. At embryonic day (E)...
Bisphenol A (BPA) is ubiquitous in the environment because of its continual application plastics and epoxy resin industry. Cadmium (Cd) a highly toxic heavy metal element mainly used smelting, electroplating, plastic dye manufacturing. Pollution as result BPA Cd exists simultaneously many agricultural regions. However, little information available regarding combined effects on plants. The photosynthesis, chlorophyll fluorescence, content soybean seedlings were investigated using noninvasive...
ABSTRACT Adhesion of motile flagella to the cell body in Trypanosoma brucei requires a filamentous cytoskeletal structure termed flagellum attachment zone (FAZ). Despite its essentiality, complete molecular composition FAZ filament and roles assembly remain poorly understood. By localization-based screening, we here identified new protein, which called FAZ2. Knockdown FAZ2 disrupted filament, destabilized multiple proteins caused cytokinesis defect. We also showed that depletion another...
The basal body shares similar architecture with centrioles in animals and is involved nucleating flagellar axonemal microtubules flagellated eukaryotes. early-branching Trypanosoma brucei possesses a motile flagellum nucleated from the that consists of mature an adjacent pro-basal body. Little known about proteome its roles biogenesis axoneme assembly T. Here, we report identification 14 conserved centriole/basal protein homologs 25 trypanosome-specific proteins. These proteins localize to...