A5020755706- Analytic and geometric function theory
- Holomorphic and Operator Theory
- Differential Equations and Boundary Problems
- Sirtuins and Resveratrol in Medicine
- Nonlinear Partial Differential Equations
- Pelvic and Acetabular Injuries
- Geometric Analysis and Curvature Flows
- Renal Diseases and Glomerulopathies
- Numerical methods in inverse problems
- Heme Oxygenase-1 and Carbon Monoxide
- Mitochondrial Function and Pathology
- Dialysis and Renal Disease Management
- Renal and related cancers
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- Polymer Synthesis and Characterization
- Mesenchymal stem cell research
- ATP Synthase and ATPases Research
- Medicinal Plants and Bioactive Compounds
- Nitric Oxide and Endothelin Effects
- Apelin-related biomedical research
- Renin-Angiotensin System Studies
- Extracellular vesicles in disease
- Algebraic and Geometric Analysis
- Autophagy in Disease and Therapy
Affiliated Hospital of Nantong University
2015-2025
Nantong University
2015-2025
Fudan University
2013-2017
Huashan Hospital
2013-2017
Huaqiao University
2007-2016
Fujian Normal University
2012
Second People's Hospital of NanTong
1998
Kyoto University
1996
The rapid growth of an aging population creates challenges regarding age-related diseases, including AKI, for which both the prevalence and death rate increase with age. molecular mechanism by aged kidney becomes more susceptible to acute injury has not been completely elucidated. In this study, we found that, compared kidneys 3-month-old mice, 20-month-old mice expressed reduced levels renal protective molecule sirtuin 1 (SIRT1) its cofactor NAD + . Supplementation nicotinamide...
TGF-β signaling plays an important role in the pathogenesis and progression of chronic kidney disease (CKD). Smad3, a transcription factor, is critical fibrogenic mediator TGF-β. Sirt1 NAD(+) -dependent deacetylase that has been reported to modify number factors exert certain beneficial health effects. This study examined effect on Smad3 its CKD. Resveratrol attenuated expression extracelluar matrix proteins both remnant 5/6th nephrectomized rats cultured mesangial cells (MMCs) exposed...
To assess the effectiveness and safety of Sacubitril/Valsartan in reducing blood pressure individuals with non-dialysis-dependent chronic kidney disease (NDD-CKD) Stage 3-5 complicated by hypertension. This study was a multicenter retrospective analysis conducted from March 1, 2022 to 31, 2024, involving adult patients NDD-CKD hypertension, who received either as monotherapy or addition current antihypertensive treatments that were insufficient. The main outcomes measured control, changes...
Angiogenesis plays an important role in the pathogenesis of diabetic nephropathy (DN). In present study, we investigated therapeutic potential resveratrol, a polyphenol with antiangiogenic activity DN. type 1 rat model, resveratrol treatment blunted increases urine albumin excretion, kidney weight and creatinine clearance rate. The glomerular diameter, mesangium accumulation, basement membrane thickness renal fibrosis rats were also reduced by treatment. kidney, increased expression vascular...
Cardiovascular and renal inflammation induced by Aldosterone (Aldo) plays an important role in the pathogenesis of hypertension fibrosis. Toll-like receptor 4 (TLR4) signaling contributes to inflammatory cardiovascular diseases, but its Aldo-induced damage is not clear. In current study, rats were treated with Aldo-salt combined TAK-242 (a TLR4 antagonist) for weeks. Hemodynamic, cardiac parameters assayed at indicated time. We found that Aldo-salt-treated present hypertrophy dysfunction....
Abstract Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD + )-dependent deacetylase belonging to class III histone deacetylases. Previous studies have shown that SIRT1 involved in kidney physiology regulation and protects the from various pathological factors. However, underlying mechanisms behind its function yet be fully elucidated. In our study, we found ablation of Sirt1 renal interstitial cells resulted more severe damage fibrosis unilateral ureteral obstruction (UUO) model...
Micro-inflammation plays an important role in the pathogenesis of spontaneously hypertensive rat (SHR). In present study, we investigated therapeutic potential resveratrol (RSV), a polyphenol with anti-fibrosis activity renal damage model. SHR model, RSV treatment blunted increase urine albumin excretion, urinary β2-microglobulin (β2-MG), attenuated decrease creatinine clearance rate (CCR). The glomerular sclerosis index (1.54±0.33 compared 0.36±0.07) and tubulointerstitial fibrosis...
Left ventricular remodeling commonly complicates end-stage renal disease following chronic kidney (CKD). This study investigated the therapeutic efficacy of resveratrol (RSV), a polyphenolic compound, on left in subtotal nephrectomy rats and sought to uncover underlying molecular mechanisms. Subtotal caused dysfunction, such as gradual increases serum creatinine blood urea nitrogen, glomerular sclerosis, tubulointerstitial fibrosis. In addition, also resulted significant myocyte...
Impaired mitochondrial function and dysregulated energy metabolism have been shown to be involved in the pathological progression of kidney diseases such as acute injury (AKI) diabetic nephropathy. Hence, improving is a promising strategy for treating renal dysfunction. NADH: ubiquinone oxidoreductase core subunit V1 (NDUFV1) an important complex I. In present study, we found that NDUFV1 was reduced kidneys ischemia/reperfusion (I/R) mice. Meanwhile, I/R induced dysfunction evidenced by...
Abstract Salidroside is a major phenylethanoid glycoside in Rhodiola rosea L., traditional Chinese medicine, with multiple biological activities. It has been shown that salidroside possesses protective effects for alleviating diabetic renal dysfunction, contrast‐induced‐nephropathy and other kidney diseases. However, the involved molecular mechanism was still not understood well. Herein, we examined of mice Adriamycin (ADR)‐induced nephropathy underlying mechanism. The results showed...
Chronic kidney disease (CKD) is often associated with muscle atrophy. However, the underlying molecular mechanisms are still not well understood. Here, we treated 5/6-nephrectomized (5/6Nx) rats resveratrol and found that this treatment greatly improves renal function as evidenced by reduced proteinuria cystatin C. Moreover, ameliorates fibrosis reducing transforming growth factor β (TGF-β) connective tissue (CTGF). Meanwhile, atrophy in these 5/6Nx was largely attenuated resveratrol....
Triptolide as a main active ingredient of Tripterygium wilfordii is known to be exerting anti-inflammatory, marked immunosuppressive, and podocyte-protective effects. In this study, we investigated the protective effect triptolide in kidney disease. Rat glomerular mesangial cells were randomly divided into three groups: (1) control group, (2) TGF-β1 (10 μg/mL) (3) group (triptolide 10 μg/L + μg/L). Sixty male Sprague-Dawley rats chronic serum sickness glomerulonephritis model (0.2 mg/kg·d)...
Abstract Accumulating evidence indicates that the extracellular matrix (ECM) is not only a consequence of fibrosis, but also contributes to progression by creating profibrotic microenvironment. Tenascin-C (TNC) an ECM glycoprotein contains multiple functional domains. We showed following kidney injury, TNC was markedly induced in fibrotic areas from both mouse models and humans with diseases. Genetically deletion mice significantly attenuated unilateral ureteral obstruction-induced fibrosis....
Given harmonic mappings <italic>f</italic>(<italic>z</italic>) = <italic>h</italic>(<italic>z</italic>) + <italic>g</italic>(<italic>z</italic>) on the unit disk <italic>D</italic> ={<italic>z</italic>||<italic>z</italic>|< 1}, where and are analytic functions <italic>D</italic>, with <italic>f</italic>(0) 0, λ<sub><italic>f</italic></sub> (0) 1 Λ<sub><italic>f</italic></sub>≤Λ, by introducing one complex parameter λ, we consider properties for...
Recent evidence indicates that mesenchymal stem cells (MSC) derived from early embryonic tissues have better therapeutic ability as compared with adult tissue-derived cells. In the present study, we transplanted human MSC (hMSC) into MRL/Lpr mice via tail vein injection to observe efficacy of hMSC and their impact on T helper 17 (Th17) cell differentiation in mice. Animals treatment group received (1 × 106/200 μL) at age 16 19 weeks. We found prolonged survival without inducing...
Abstract Sepsis‐associated acute kidney injury (AKI) has high morbidity and mortality, but without cause‐specific treatment. Erythropoietin derived Helix B surface peptide (HBSP) alleviates AKI, whereas its underlying mechanisms remain to be further explored. Here, the effects of HBSP on pyroptosis, apoptosis, macrophage polarization repair were investigated in lipopolysaccharide (LPS)‐induced AKI mouse model cultured epithelial cells. Systemic inflammation, compromised renal function...
Some sharp estimates of coefficients, distortion, and growth for harmonic mappings with analytic parts convex or starlike functions order<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:math>are obtained. We also give area covering theorems. Our main results generalise those Klimek Michalski.
Aims: Intercellular adhesion molecule-1 (ICAM-1) plays an important role in the inflammatory process and immune response. The aim of study was to investigate ICAM-1 expression kidneys spontaneously hypertensive rats (SHRs) relationship between level renal damage. Methods: Male Wistar–Kyoto (WKY) rat SHR models were employed. Blood pressure (BP) recorded using tail cuff method. Twenty-four hour proteinuria β2-microglobulin (β2-MG) measured biuret method radioimmunity kits, respectively....