A5100372410- Extracellular vesicles in disease
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- Renal and related cancers
- Renal Diseases and Glomerulopathies
- MicroRNA in disease regulation
- Telomeres, Telomerase, and Senescence
- Epigenetics and DNA Methylation
- Nutrition and Health in Aging
- Parathyroid Disorders and Treatments
- Fibroblast Growth Factor Research
- Genetic Syndromes and Imprinting
- Blood Pressure and Hypertension Studies
- COVID-19 Clinical Research Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Erythropoietin and Anemia Treatment
- Complement system in diseases
- Body Composition Measurement Techniques
- Dendrimers and Hyperbranched Polymers
- Autoimmune and Inflammatory Disorders Research
- Lysosomal Storage Disorders Research
- Chemotherapy-induced organ toxicity mitigation
- COVID-19 Impact on Reproduction
- Phagocytosis and Immune Regulation
Zhongda Hospital Southeast University
2018-2025
Shandong University of Traditional Chinese Medicine
2025
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2025
Southeast University
2021-2025
Shenzhen University
2025
University of Hong Kong
2023
University of Hong Kong - Shenzhen Hospital
2023
Southeast University
2023
Emory University
2022
Centre for Human Genetics
2020
Recently, extracellular vesicles (EVs) have been attracting strong research interest for use as natural drug delivery systems. We report an approach to manufacturing interleukin-10 (IL-10)-loaded EVs (IL-10+ EVs) by engineering macrophages treating ischemic acute kidney injury (AKI). Delivery of IL-10 via enhanced not only the stability IL-10, but also its targeting due adhesive components on EV surface. Treatment with IL-10+ significantly ameliorated renal tubular and inflammation caused...
Mesenchymal stem cells-derived exosomes (MSC-exos) have attracted great interest as a cell-free therapy for acute kidney injury (AKI). However, the
Abstract Inflammation is a major contributor to the pathogenesis of ischemic acute kidney injury (AKI), which complicates post-operative outcomes large numbers hospitalized surgical patients. Hydroxychloroquine (HCQ), well-known anti-malarial drug, commonly used in clinical practice for its anti-inflammatory actions. However, little known about role renal ischemia/reperfusion (I/R) injury. In current study, mice were subjected I/R and HCQ was administered seven days by gavage prior surgery....
This study aims to explore the relationship between Dietary Index for Gut Microbiota (DI-GM) and diabetes. In recent years, there has been increasing attention role of gut microbiome in regulating host metabolism. However, DI-GM risk diabetes not sufficiently studied. utilized relevant data from National Health Nutrition Examination Survey (NHANES) 2007-2018. Multiple logistic regression analysis was conducted The dose-response observed using restricted cubic splines (RCS). Threshold effect...
Although glucocorticoids are the mainstays in treatment of renal diseases for decades, dose dependent side effects have largely restricted their clinical use. Microvesicles (MVs) small lipid-based membrane-bound particles generated by virtually all cells. Here we show that RAW 264.7 macrophage cell-derived MVs can be used as vectors to deliver dexamethasone (named MV-DEX) targeting inflamed kidney efficiently. Methods: macrophages were incubated with and then MV-DEX was isolated from...
Significance Statement AKI is a frequent clinical problem without definitive therapies. We developed an efficient RNAi therapy against by engineering red blood cell-derived extracellular vesicles (REVs) with targeting peptides and therapeutic siRNAs. REVs targeted Kim-1–binding peptide LTH efficiently delivered P65 Snai1 siRNAs to the injured tubules, leading reduced expression of P-p65 Snai1. Dual suppression inhibited renal inflammation fibrosis in mice subjected ischemia/reperfusion...
Abstract Background Muscle wasting is a common complication of chronic kidney disease (CKD) that associated with higher mortality. Although the mechanisms myofibre loss in CKD has been widely studied, contribution muscle precursor cell (MPC) senescence remains poorly understood. Senescent MPCs no longer proliferate and can produce proinflammatory factors or cytokines. In this study, we tested hypothesis secretory phenotype (SASP) contributes to CKD‐induced atrophy weakness. Methods was...
Chronic kidney disease (CKD) is highly prevalent worldwide, and its global burden substantial growing. CKD displays a number of features accelerated senescence. Tubular cell senescence common biological process that contributes to progression. Tubulointerstitial inflammation driver tubular characteristic CKD. However, the mechanism by which interstitial drives remains unclear. This paper aims explore role exosomal miRNAs derived from macrophages in development
To assess the effectiveness and safety of Sacubitril/Valsartan in reducing blood pressure individuals with non-dialysis-dependent chronic kidney disease (NDD-CKD) Stage 3-5 complicated by hypertension. This study was a multicenter retrospective analysis conducted from March 1, 2022 to 31, 2024, involving adult patients NDD-CKD hypertension, who received either as monotherapy or addition current antihypertensive treatments that were insufficient. The main outcomes measured control, changes...
Abstract Acute myeloid leukemia (AML) is the most common type of in adults. AML cells secrete angiogenic factors to remodel vasculature and acquire chemoresistance; however, antiangiogenic drugs are often ineffective treatment. Cancer cell‐derived exosomes can induce angiogenesis, but their role vascular remodeling during unclear. Here, we found that secreted by promoted proliferation migration tube‐forming activity human umbilical vein endothelial (HUVECs), whereas HUVECs conferred...
Abstract Background The progression and geographical distribution of SARS coronavirus 2 (SARS-CoV-2) infection in the UK elsewhere is unknown because typically only symptomatic individuals are diagnosed. We performed a serological study blood donors Scotland between 17 th March 18 May to detect neutralising antibodies SARS-CoV-2 as marker past epidemic progression. Aim To determine if sera from bank can be used track emergence epidemic. Methods A pseudotyped virus microneutralisation assay...
Peritubular capillaries (PTCs) are closely related to renal tubules in structure and function, both pivotal regulators the development progression of acute kidney injury (AKI). However, mechanisms that underlie interaction between PTCs during AKI remain unclear. Here we explored a new mode tubulovascular crosstalk mediated by small extracellular vesicles (sEV) after AKI. In response ischemia/reperfusion (I/R) injury, endothelial proliferation tubular expression vascular growth factor-A...
This study aimed to investigate the association between phase angle (PhA) and sarcopenia evaluate its performance as a predictor in patients receveing maintenance hemodialysis (MHD).All enrolled underwent handgrip strength (HGS) 6-m walk test, muscle mass was measured using bioelectrical impedance analysis. Sarcopenia diagnosed according diagnostic criteria of Asian Working Group. Logistic regression analysis used PhA an independent after adjusting for confounding factors. The receiver...
Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have emerged as a promising approach in regenerative therapy. However, the clinical application of MSC-EVs is hindered by presence xenogenic components, such fetal bovine serum (FBS), which most used culture supplement for MSCs. Human platelet lysate (HPL) has been proposed an alternative to FBS, but whether derived from HPL-cultured MSCs are suitable translation remains unclear. In this study, we comprehensively compared...
Objective To compare the real-world clinical efficacy and safety of interleukin (IL)-17A inhibitors (secukinumab [SEC] ixekizumab [IXE]) versus IL-23 inhibitor guselkumab (GUS) in patients with nail psoriasis, a focus on site-specific biologic therapeutic responses (nail matrix vs. bed) 24-week prospective observational cohort. Methods This cohort enrolled 65 adult plaque psoriasis dermoscopy-confirmed involvement, stratified into three treatment groups: SEC (n=25), IXE (n=20), GUS (n=20)....
Introduction: The prevalence of urinary myeloid bodies in Fabry disease patients and their correlation with renal involvement remains unclear. Methods: This single-center, retrospective study included 25 27 controls. We analyzed 24-hour urine samples for the presence evaluated clinical data, including serum creatinine, estimated glomerular filtration rate (eGFR), protein levels, α-Gal A, Lyso-GL-3. Seven underwent analysis before after one year enzyme replacement therapy (ERT). Results:...