A5102934588- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Cancer Immunotherapy and Biomarkers
- NF-κB Signaling Pathways
- interferon and immune responses
- MicroRNA in disease regulation
- Paraoxonase enzyme and polymorphisms
- Immune Response and Inflammation
- Trace Elements in Health
- Wound Healing and Treatments
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Genomics, phytochemicals, and oxidative stress
- Hippo pathway signaling and YAP/TAZ
- Lipid metabolism and disorders
- Estrogen and related hormone effects
- T-cell and Retrovirus Studies
- Head and Neck Cancer Studies
- Autophagy in Disease and Therapy
Shanghai Jiao Tong University
2009-2025
Shenzhen Center for Disease Control and Prevention
2025
Affiliated Zhongshan Hospital of Dalian University
2025
Johns Hopkins University
2024
Xinqiao Hospital
2012-2024
Army Medical University
2014-2024
Harbin Medical University
2016-2024
Sichuan University
2024
West China Second University Hospital of Sichuan University
2024
Second Affiliated Hospital of Harbin Medical University
2024
Abstract Activation of the IκB kinase (IKK) complex by LPS induces phosphorylation and degradation IκBα, leading to nuclear translocation NF-κB. Although it is essential for NF-κB activation, emerging evidence has indicated that not sufficient activate NF-κB-dependent transcription. Here, we reported induced p65 trans-activation domain on serine 536 in monocytes/macrophages. Using mouse embryonic fibroblasts lacking either IKKα or IKKβ, found IKKβ played an role LPS-induced 536, while was...
The pathological mechanisms of radiation ulcer remain unsolved and there is currently no effective medicine. Here, we demonstrate that persistent DNA damage foci cell senescence are involved in development. Further more, identify cordycepin, a natural nucleoside analogue, as potent drug to block (skin, intestine, tongue) rats/mice by preventing through the increase NRF2 nuclear expression (the assay used mainly on skin). Finally, cordycepin also revealed activate AMPK binding with α1 γ1...
Hepatocyte growth factor (HGF), also known as a scatter factor, regulates variety of biological activities including cell proliferation, survival, migration, and angiogenesis. Importantly, HGF its receptor c-Met have been found to be associated with metastasis human head neck squamous carcinoma (HNSCC). Because anoikis resistance plays an important role in tumor progression metastasis, here we examined whether suppressed suspension-induced apoptosis (anoikis) HNSCC cells, if so, assessed...
Background: Coronary artery disease (CAD) is a major problem worldwide. As an endothelium-enriched microRNA (miRNA), miR-126 has been reported to serve as potential biomarker of acute myocardial infarction. However, the relationship between and severity CAD remains unknown. This study was designed test whether circulating levels are associated with CAD. Methods: The present enrolled 40 patients who had risk factors for without angiographically significant CAD, 110 presenting stable angina...
Aberrant expression of long non-coding RNAs (lncRNA) is associated with altered DNA methylation and histone modifications during carcinogenesis. However, identifying epigenetically dysregulated lncRNAs characterizing their functional mechanisms in different cancer subtypes are still major challenges for studies. In this study, we systematically analyzed the epigenetic alterations at important regulatory elements three breast subtypes. We identified 87, 691, 1,197 luminal, basal, claudin-low...
Metabolic reprogramming in tumor-associated macrophages (TAM) is associated with cancer development, however, the role of macrophage triglyceride metabolism metastasis unclear. Here, we showed that TAMs exhibited heterogeneous expression abhydrolase domain containing 5 (ABHD5), an activator hydrolysis, migratory expressing lower levels ABHD5 compared nonmigratory TAMs. inhibited cell migration vitro xenograft models and genetic models. The effects on were dissociated from its metabolic...
Porphyromonas gingivalis is an etiologic pathogen of periodontitis that one the most common inflammatory diseases. Recently, we found P. LPS activated transcription factor nuclear factor-kappaB (NF-kappaB) through IkappaB kinase complex (IKK). NF-kappaB a controls inflammation and host responses. In this study, examined role IKK/NF-kappaBin LPS-induced gene expression on genome-wide basis using combination microarray biochemical approaches. A total 88 early response genes were to be induced...
BACKGROUND:Metformin is a widely used biguanide drug for the treatment of type 2 diabetes. It has been revaluated as potential anti-cancer with promising activity in various tumors. However, precise mechanisms underlying suppression cancer cells by metformin remain not well understood. MATERIAL AND METHODS:In this study, human renal cell carcinoma line ACHN was to investigate anti-proliferation effect metformin. A counting kit-8 assay detect viability. The cycle distribution and apoptosis...
Background Replication of mammalian genomes requires the activation thousands origins which are both spatially and temporally regulated by as yet unknown mechanisms. At most fundamental level, our knowledge about distribution pattern in each chromosomes, among different cell types, whether physiological state cells alters this is at present very limited. Methodology/Principal Findings We have used standard λ-exonuclease resistant nascent DNA preparations size range 0.7–1.5 kb obtained from...
The purpose of this study was to investigate the therapeutic effects hyperoside (Hyp) on glomerulosclerosis in diabetic nephropathy and its underlying mechanisms. Blood glucose, kidney mass, renal function mice were measured. Renal morphology observed using hematoxylin eosin, periodic acid - Schiff's, Masson's trichrome stain. Fibronectin (FN) collagen IV (COL IV) determined by Western blot immunohistochemical studies. Matrix metalloproteinases (MMP)-2 -9 tissue inhibitors metalloproteinase...
Background: Human paraoxonase (PON) is an enzyme involved in vasodilation and thrombosis. Disruption of blood blow through the placenta could be part pathophysiological mechanism leading to preterm delivery. The purpose this study was examine association between polymorphisms 2 genes (PON1 PON2) Methods: We conducted a case-control using infant-parents triads Anqing, China. Between July 1999 June 2001, we enrolled families 105 infants born at term 80 preterm. Genotyping performed for PON1...
The authors investigated whether polymorphisms in two maternal metabolic genes, cytochrome P-450 1A1 (CYP1A1) MspI and epoxide hydrolase 1 (EPHX1) Tyr113His, affect the association of passive smoking with infant birth weight. study was conducted a cohort 1,388 newly married mothers liveborn singletons who worked textile mills Anqing, China, from 1996 to 2000. Multiple linear regression models were used estimate associations genetic susceptibility weight, adjustment for important potential...
// Qingjian Wu 1, * , Fan Yang 2, Zhenxing 1 Zhenqiang Fang Wanlei Fu 3 Wei Chen Xiaobing Liu Jiang Zhao Qingqing Wang Xiaoyan Hu and Longkun Li Department of Urology, Second Affiliated Hospital, Third Military Medical University, Chongqing 400037, China 2 Center Experiment & Technique, Pathology, These authors have contributed equally to this work Correspondence to: Li, email: lilongk@hotmail.com Keywords: plasmacytoma variant translocation (PVT1); clear cell renal carcinoma (CCRCC); long...
Rationale: Fibroblasts, the predominant cell type responsible for tissue fibrosis, are heterogeneous, and targeting of unique fibrogenic population fibroblasts is highly expected. Very recently, elevated glycolysis demonstrated to play a pivotal role in determination phenotype fibroblasts. However, it lack specific strategies elimination such populations. In this study, novel strategy use near-infrared (NIR) dye IR-780 glycolytic control cutaneous scarring developed. Methods: The...
Existing cross-sectional and retrospective studies were unable to establish a causal relationship between psoriasis cutaneous melanoma (CM). We sought evaluate the role CM.