A5102783082- RNA modifications and cancer
- interferon and immune responses
- Immune cells in cancer
- Ubiquitin and proteasome pathways
- Genetic Associations and Epidemiology
- Cancer-related gene regulation
- Hemoglobinopathies and Related Disorders
- Immune Cell Function and Interaction
- Histone Deacetylase Inhibitors Research
- Neutropenia and Cancer Infections
- Sphingolipid Metabolism and Signaling
- ATP Synthase and ATPases Research
- Cancer Mechanisms and Therapy
- Heat shock proteins research
- Chemotherapy-related skin toxicity
- Biochemical and Molecular Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Platelet Disorders and Treatments
- Alcohol Consumption and Health Effects
- MicroRNA in disease regulation
- Cancer Treatment and Pharmacology
- Cell death mechanisms and regulation
- Autophagy in Disease and Therapy
- Gout, Hyperuricemia, Uric Acid
The First Affiliated Hospital, Sun Yat-sen University
2023-2024
Southern Medical University
2024
Nanfang Hospital
2024
Sun Yat-sen University
2019-2024
Key Laboratory of Guangdong Province
2023
Sun Yat-sen University Cancer Center
2019
Shanghai Institute of Hematology
2009
Shanghai Jiao Tong University
2009
Abstract Background Osteosarcoma is the most common malignant primary bone tumor in infants and adolescents. The lack of understanding molecular mechanisms underlying osteosarcoma progression metastasis has contributed to a plateau development current therapies. Endoplasmic reticulum (ER) stress emerged as significant contributor tumors, but its potential regulatory remain unknown. Methods In this study, we collected RNA sequencing clinical data from TCGA, GSE21257, GSE33382 cohorts....
Osteosarcoma is the most common primary malignant bone tumor with elevated disability and mortality rates in children adolescents therapeutic effect for osteosarcoma has remained stagnant past 30 years. Emerging evidence shown ceramide metabolism plays a vital role progression, but its mechanisms progression remain unknown. Through consensus clustering LASSO regression analysis based on cohorts from TARGET database, we constructed metabolism-related prognostic signature including ten genes...
Osteosarcoma is a bone-derived malignancy that often leads to lung metastasis and death.
Background: Chemotherapy-induced thrombocytopenia (CIT) commonly exacerbates the difficulty of cancer treatment, increasing bleeding risks and potentially reducing chemotherapy dosage, ultimately impacting its efficacy. However, there are limited studies about avatrombopag application in acute lymphoblastic leukemia (ALL) CIT. Objectives: We aimed to evaluate efficacy safety treating CIT patients diagnosed with ALL. Design: This retrospective study, using propensity score matching, included...
Abstract BACKGROUND TMZ, is the first line chemotherapeutic drug for glioma, and resistance one of most important reasons glioma treatment failure. Our previous studies have found that: 1) Type I interferon (IFN) could reverse TMZ by inhibiting NF-κB activity, down-regulating expression MGMT in vivo vitro; 2) IFN-α significantly improve chemtherapeautic effect GBM patients. We aim to investigate therapeutic a cocktail chemotherapy regimen combining temozolomide (TMZ)- Levetiracetam(LEV) - on...