A5067628442- Gestational Diabetes Research and Management
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- RNA and protein synthesis mechanisms
- Mechanical Circulatory Support Devices
- Antiplatelet Therapy and Cardiovascular Diseases
- CRISPR and Genetic Engineering
- Bacterial Infections and Vaccines
- Pregnancy and preeclampsia studies
- Peroxisome Proliferator-Activated Receptors
- ECG Monitoring and Analysis
- Cytomegalovirus and herpesvirus research
- Genetic Neurodegenerative Diseases
- Congenital Heart Disease Studies
- Birth, Development, and Health
- Genomics and Chromatin Dynamics
- MicroRNA in disease regulation
- Kruppel-like factors research
- Neurological and metabolic disorders
- Cardiovascular Function and Risk Factors
- Sexual Differentiation and Disorders
- Artificial Intelligence in Healthcare
- Complement system in diseases
- Metabolism and Genetic Disorders
- Cancer-related molecular mechanisms research
ShanghaiTech University
2025
First Affiliated Hospital of Zhengzhou University
2016
Sun Yat-sen University
2010-2012
Sun Yat-sen Memorial Hospital
2010-2012
Xi'an Jiaotong University
2011
Qilu Hospital of Shandong University
2007
Background: Coronary artery disease (CAD) is a major problem worldwide. As an endothelium-enriched microRNA (miRNA), miR-126 has been reported to serve as potential biomarker of acute myocardial infarction. However, the relationship between and severity CAD remains unknown. This study was designed test whether circulating levels are associated with CAD. Methods: The present enrolled 40 patients who had risk factors for without angiographically significant CAD, 110 presenting stable angina...
Drosophila P75 (dP75), a homolog of the human LEDGF/p75, is crucial for oogenesis by recruiting histone kinase Jil-1 to euchromatin and impeding H3K9me2 spreading. Like LEDGF, dP75 binds transcriptionally active chromatin, but its precise mechanism remains unclear. Here we show that PWWP domain prefers binding thymidine-rich DNA over GC-rich sequences. Crystal structures both in apo ssDNA-bound states, reveal domain-swapped homodimer. The aromatic cage, known recognize methyllysine, also...
<h3>Objective</h3> The mechanisms underlying the inhibitory effects of PPARγ agonists on Ang II-induced VSMC proliferation and II/KLF5-dependent signalling pathway remain unclear. <h3>Methods</h3> Sprague–Dawley rats received II (150 ng/kg/min) with or without rosiglitazone (5 mg/kg/day) for seven days. Real-time RT-PCR, immunohistochemistry, western blot, DNA binding assay were performed in rat aorta cultured vascular smooth muscle cells. MTT flow cytometry used to measure cell...
Objective To explore the therapeutic effect of intravenous immunoglobulin(IVIG)on children with epilepsy and its mechanism to provide evidence for clinical application IVIG into management epilepsy.Methods We retrospectively reviewed data 98 childhood-onset treated IVIG.Sixty-six health were chosen as control group.The efficacy,tolerability,safety serum immunological parameters these patients mainly evaluated immunologicla parameters,including T-1ymphocyte subsets immunoglobulin,were...