A5101852422- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Inflammatory Biomarkers in Disease Prognosis
- Sepsis Diagnosis and Treatment
- Renal cell carcinoma treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Mechanisms and Therapy
- Neutropenia and Cancer Infections
- Metastasis and carcinoma case studies
- Acute Myeloid Leukemia Research
- Chronic Kidney Disease and Diabetes
- Immune cells in cancer
- Nutrition and Health in Aging
- Ion Channels and Receptors
- Global Public Health Policies and Epidemiology
- Bladder and Urothelial Cancer Treatments
- Adipose Tissue and Metabolism
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ferroptosis and cancer prognosis
- Inflammation biomarkers and pathways
- Spinal Fractures and Fixation Techniques
- Cancer, Stress, Anesthesia, and Immune Response
- Phytoestrogen effects and research
- Pain Management and Treatment
Shandong First Medical University
2022-2024
First Affiliated Hospital of Bengbu Medical College
2021-2024
Shandong Provincial QianFoShan Hospital
2024
Guangxi Academy of Sciences
2023
Academy of Medical Sciences
2023
Northwest A&F University
2022-2023
China-Japan Friendship Hospital
2023
Shandong Tumor Hospital
2022-2023
Army Medical University
2022
Xinqiao Hospital
2022
Although the antitumor efficacy of docetaxel (DTX) has long been attributed to antimitotic activities, its impact on tumor microenvironment (TME) recently gained more attention. Macrophages are a major component TME and play critical role in DTX efficacy; however, underlying action mechanisms remain unclear.DTX chemotherapeutic was demonstrated via both macrophage depletion C-C motif chemokine ligand 3 (Ccl3)-knockout transgenic allograft mouse model. Ccl3-knockdown Ccl3-overexpressing...
Tumour-associated macrophages (TAMs) abundantly infiltrate high-grade gliomas and orchestrate immune response, but their diversity in isocitrate dehydrogenase (IDH)-differential grade 4 remains largely unknown. This study aimed to dissect the transcriptional states, spatial distribution, clinicopathological significance of distinct monocyte-derived TAM (Mo-TAM) microglia-derived (Mg-TAM) clusters across glioblastoma-IDH-wild type astrocytoma-IDH-mutant-grade (Astro-IDH-mut-G4). Single-cell...
The accumulation of organic selenium (Se) by lactic acid bacteria (LAB) showed excellent biosafety and absorption efficiency. Identification Se-enriched strains the production products fermentation are popular research areas. However, there few studies that focus on distribution characteristics Se in cells. In this study, a dominant Lactobacillus Paracasei 20241 was selected to characterize cell surface inside cell. results L. paracei can convert sodium selenite into zero-valent Se. former...
Background: Inflammation plays a critical role in sepsis. The integration of neutrophil-to-lymphocyte ratio (NLR) and platelets-to-lymphocytes (PLR) from multiple cell types offers novel approach to rapidly assess inflammation status. However, the predictive NLR PLR sepsis with lymphopenia remains uncertain. Objectives: purpose this study was explore prognostic value patients lymphopenia. Design methods: In observational retrospective study, we included 172 collected clinical characteristics...
Abstract Intracellular Ca 2+ dysregulation is a key marker in septic cardiac dysfunction; however, regulation of the classic regulatory modules cannot successfully abolish this symptom. Here we show that knockout transient receptor potential canonical (TRPC) channel isoforms TRPC1 and TRPC6 can ameliorate LPS-challenged heart failure prolong survival mice. The LPS-triggered release from endoplasmic reticulum both cardiomyocytes macrophages significantly inhibited by Trpc1 or Trpc6 knockout....
Background: Given the high incidence and mortality of cervical cancer (CC) among women in developing countries, identifying reliable biomarkers for prediction prognosis therapeutic response is crucial. We constructed a prognostic signature cuproptosis-related long non-coding RNAs (lncRNAs) as reference individualized clinical treatment. Methods: A total seven lncRNAs closely related to patients with CC were identified used construct via least absolute shrinkage selection operator regression...
BACKGROUND Chemoradiotherapy (CRT) is widely accepted and considered a standard treatment, particularly for unresectable inoperable esophageal squamous cell carcinoma (ESCC). However, the optimal use of combined modalities chemotherapy (CT) radiotherapy (RT) remains controversial. In addition, no consensus has been reached regarding exact efficacy consolidation (CCT) most appropriate dose. MATERIAL AND METHODS Clinical data from 262 ESCC patients treated with CRT (n=165) or RT alone (n=97)...
BACKGROUND Population‐based studies have demonstrated survival disparities related to socioeconomic factors for patients with acute myeloid leukemia (AML). The objective of the current study was determine whether local health care infrastructure, represented by Area Health Education Centers (AHEC) region, or treating center experience, National Cancer Institute Comprehensive Center (NCICCC) designation, were associated outcomes among AML in North Carolina. METHODS Patients who diagnosed from...
Population-based studies suggest that patients with multiple myeloma (MM) have better outcomes when treated at high-volume facilities, but the relative contribution of provider expertise and hospital resources to improved is unknown. This study explored how treating facility, individual volume, patient-sharing between MM specialists community providers influenced for MM.A state cancer registry linked public private insurance claims was used identify a cohort diagnosed in 2006 through 2012....
Biliary tract cancers, broadly described as malignancies that arise from the biliary epithelia, are usually divided into two major clinical phenotypes: cholangiocarcinoma and gallbladder cancer, differing in etiopathogenesis, risk factors, perhaps molecular genetic signatures. Atypical symptoms lack of tumor biomarkers make it difficult to diagnose early stages. At time presentation, few patients candidates for potentially curative surgical resection. We here assessed compared features a...
To improve the diagnosis of primary gallbladder carcinoma (GBC) with/without hepatic metastases by analyzing our experience different GBC treatment in patients.A retrospective study was carried out to analyze clinical data 139 patients with who underwent resection unit from January 2003 December 2007. Patients were divided into two groups according whether they demonstrated invasion. Tumor presentation, surgical modes, and prognosis each patient retrospectively reviewed. Kaplan-Meier curves...
Implementation of comprehensive rehabilitation therapy in postoperative care patients with cholangiocarcinoma was studied to explore its impact on patients' quality life. Two hundred and nineteen who underwent surgery Yidu Central Hospital Weifang from April 2014 June 2017 were selected as study subjects. Of these patients, 116 received therapy, addition chemotherapy, after assigned the experimental group. The remaining 103 routine treatment control Under guidance experts, group carried out...
This study aims to evaluate the prognosis and serum immune cells of patients with different pretreatment body mass index (BMI) values. The data 61 newly diagnosed advanced lung squamous cell carcinoma (LSCC) who received checkpoint inhibitors (ICIs) combined chemotherapy were obtained from database Rizhao People's Hospital (Rizhao, Shandong). According cutoff value BMI (23.2 kg/m2), 32 had a high remaining 29 low BMI. effects BMIs on analyzed. median progression-free survival (PFS) times...
To evaluate the vertebral bone mineral density and value of stand-alone oblique lumbar interbody fusion (SA OLIF) for management single-level adjacent segment disease (ASD) primary degenerative diseases.Seventy-eight patients undergoing SA OLIF was divided into index surgery group (n = 36) or revision 42) at single center. The body Hounsfield units (HU) measured to assess operated level by preoperative CT. following data were retrospectively collected compared between two groups:...
The aim is to develop a staged clinical laparoscopic training program (without laboratory trainings) for beginners perform adrenalectomy (LA) and determine its safety feasibility. Five with no previous experience in were randomly selected receive the training, including open retroperitoneal or radical nephrectomy mentor-initiated training. data of 15 LAs performed by each trainees collected compared from initial mentor. All completed successfully, procedure required conversion surgery....
Aims: Transient receptor potential canonical-6 (TRPC6) is a therapeutic target for hepatocellular carcinoma. The authors aimed to synthesize and determine whether indole-2-carboxamide derivatives have anti-hepatocellular carcinoma activities targeting TRPC6. Materials & methods: Molecular docking was carried out design these derivatives. top five compounds were synthesized activity validation using microscale thermophoresis. Cell cytotoxicity, flow cytometry, western blotting cell...
For the first time, we investigated oncological role of plexin domain-containing 1 (
Objective To retrospectively analyze the relationship between clinicopathological,biological characteristics and outcome of renal cell carcinoma(RCC) evaluate risk factors related to metastasis in young patients.Methods The data 83 RCC patients younger than 40-year-old, treated from January 1986 December 2007 Tianjin Cancer Hospital,were analyzed retrospectively.The complete follow-up cases were collected.The operative methods included partial radical surgery.Clinical staging consistent with...