A5100634258- Medical Research and Treatments
- Traditional Chinese Medicine Studies
- Traditional Chinese Medicine Analysis
- Renal Diseases and Glomerulopathies
- Cancer Immunotherapy and Biomarkers
- Intracerebral and Subarachnoid Hemorrhage Research
- Gynecological conditions and treatments
- Folate and B Vitamins Research
- Acute Ischemic Stroke Management
- Healthcare and Venom Research
- Cardiac, Anesthesia and Surgical Outcomes
- Plant Virus Research Studies
- Insect-Plant Interactions and Control
- Mesenchymal stem cell research
- Cardiac Ischemia and Reperfusion
- Food Allergy and Anaphylaxis Research
- Intensive Care Unit Cognitive Disorders
- Parathyroid Disorders and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Viral gastroenteritis research and epidemiology
- Allergic Rhinitis and Sensitization
- Pain Mechanisms and Treatments
- Reproductive System and Pregnancy
- Prenatal Screening and Diagnostics
- Cardiovascular Health and Risk Factors
Zhejiang University
2009-2025
Sichuan University
2020-2025
Chengdu Medical College
2023-2025
Fujian Medical University
2025
Gansu Agricultural University
2025
Wenzhou Medical University
2024
First Affiliated Hospital of Wenzhou Medical University
2024
Guiyang Medical University
2024
Huzhou Central Hospital
2023-2024
Zhengzhou Children's Hospital
2022-2024
Abstract Background SARS‐CoV‐2 has spread worldwide causing more than 400 million people with virus infections since early 2020. Currently, the existing vaccines targeting spike glycoprotein (S protein) of are facing great challenge from infection and its multiple S protein variants. Thus, we need to develop a new generation prevent Compared protein, nucleocapsid (N is conservative less mutations, which also plays vital role in viral infection. Therefore, N may have potential for developing...
Abstract Tigecycline is regarded as the last line of defense to combat multidrug-resistant Klebsiella pneumoniae . However, increasing utilization has led rising drug resistance and treatment failure. Here, we design a D-alpha tocopheryl polyethylene glycol succinate-modified S-thanatin peptide-functionalized nanorods based on calcium phosphate nanoparticles for tigecycline delivery pneumonia therapy caused by tigecycline-resistant After incubation with bacteria, fabricated can enhance...
Background/Aims: Autophagy is an evolutionarily conserved catabolic mechanism to maintain energy homeostasis and remove damaged cellular components, which plays important role in the survival of various cells. Inhibiting autophagy often applied as a new strategy halt growth cancer Methods: The effect FOXO1 gene on function apoptosis its underlying mechanisms were investigated cultured QBC939 cells by methylthiazoletetrazolium (MTT) assay, western blot, DCFDA mitochondrial membrane potential,...
A number of effective strategies have been developed to improve the quality life in patients with COPD. However, few implemented COPD at all stages a community setting. This study evaluated efficacy complex health management intervention rural communities China.A randomized controlled trial including 8,217 subjects was from May 2008 2012 14 health-care centers. The control group received usual care, whereas participated program that included assessing subjects' status, giving regular...
Rotaviruses and noroviruses are important causes of acute gastroenteritis in children. While previous studies China have mainly focused on rotavirus, we investigated the incidence norovirus addition to rotavirus Southwestern China.From January 2018 December 2020, cases or infections among children under five ages with were evaluated retrospectively.The detection rate was 24.5% (27,237/111,070) 26.1% (4649/17,797). Among 17,113 submitted for dual testing both norovirus, mixed...
Abstract Acute lung injury (ALI) is a severe condition that can progress to acute respiratory distress syndrome (ARDS), with high mortality rate. Currently, no specific and compelling drug treatment plan exists. Mesenchymal stem cells (MSCs) have shown promising results in preclinical clinical studies as potential for ALI other lung‐related conditions due their immunomodulatory properties ability regenerate various cell types. The present study focuses on analyzing the role of umbilical cord...
The use of hydroxyethyl starch 130/0.4 has been linked to renal injury in critically ill patients, but its impact on surgical patients remains uncertain. A retrospective cohort study. This study was conducted at one tertiary care hospital China. We evaluated the records 51,926 Chinese adults who underwent noncardiac surgery from 2013 2022. Patients given a combination and crystalloids were propensity-matched 1: 1 ratio baseline characteristics only (11,725 pairs). Eligible divided into those...
Abstract Sri Lankan cassava mosaic virus (SLCMV) is a prominent causative agent of disease in Asia and relies on the whitefly Bemisia tabaci cryptic complex for its transmission. However, molecular mechanisms involved SLCMV transmission by B. have yet to be understood. In this study, we identified an aminopeptidase N‐like protein (BtAPN) II 1, efficient vector SLCMV, which process. Through use glutathione S‐transferase pull‐down assay LC‐MS/MS analysis, demonstrated interaction between BtAPN...
Background Breastfeeding technique (BFT) is determined by the mother’s and infant’s positioning, attachment to breast, suckling behavior. Understanding breastfeeding mothers’ skills crucial for clinical practice designing interventions improve practices. This study aimed determine prevalence determinants of effective BFT among early post-partum mothers. Methods We conducted a cross-sectional 415 mothers in Fuzhou, China. Participants were recruited using systematic random sampling technique....
Cytokines are crucial in various physiological and pathological processes, especially inflammatory diseases mammals. However, the comprehensive identification of cytokines their potential regulatory functions mammary glands Holstein cows suffering from clinical mastitis (CM) remains only partially understood. This study aimed to systematically identify biological processes (BPs) differentially expressed proteins (DEPs) associated with explore through analysis previously obtained data...
Abstract Microbial-derived metabolites are important mediators of host–microbial interactions. In recent years, the role intestinal microbial in colorectal cancer has attracted considerable attention. These metabolites, which can be derived from bacterial metabolism dietary substrates, modification host molecules such as bile acids, or directly bacteria, strongly influence progression colitis-associated (CAC) by regulating inflammation and immune response. Here, we review how microbiome...
In this study we tested the hypothesis that hyperbaric oxygen preconditioning (HBO-PC) reduces retinal neuronal death due to optic nerve crush (ONC). Adult male Sprague-Dawley rats were subjected ONC accompanied by a contralateral sham operation. HBO-PC was conducted four times giving 100% at 2.5 atmospheres absolute (ATA) for 1 h every 12 2 days prior ONC. The euthanized or weeks after Retinal ganglion cell (RGC) density counted hematoxylin and eosin (H&E) staining of retina retrograde...
Danshen-Gegen (DG) decoction, an herbal formulation comprised of Radix Salvia Miltiorrhiza and Puerariae Lobata, is prescribed for the treatment coronary heart disease in Chinese medicine. Experimental clinical studies have indicated that DG decoction can reduce extent atherosclerosis. In present study, using exvivo rat model myocardial ischemia/reperfusion (I/R) injury, we investigated preconditioning effect aqueous extract prepared from optimized weight-to-weight ratio Danshen Gegen....
With the increasing incidence rate of chronic kidney disease (CKD), inappropriate use medicine in CKD patients is an important issue, as it may cause adverse effects and progression to renal failure.The aim this study assess frequency among patients.A cross-sectional was conducted from November 1 December 1, 2014 a Chinese teaching tertiary hospital. All medication prescriptions for with serum creatinine level above normal value were enrolled. The prescriptions, including unreasonable...
Background In this study, we analyzed the characteristics of different stenosis types in idiopathic intracranial hypertension (IIH) patients with venous sinus (VSS) using intravascular ultrasound (IVUS). Methods We retrospectively reviewed data from who underwent IVUS evaluation during venography or stenting procedures between January 2014 and February 2022. Results Among 80 intrinsic lesions, 47 cases were identified, including 41 single lesions 6 multiple lesions. Single consisted 36 AG, 3...
The solubilities of florfenicol in water, methanol, ethanol, acetone, tetrahydrofuran, 1-propanol, and water + acetone solvent mixtures from (278 to 318) K were measured with the mole fraction at atmospheric pressure. light extinction method was used determine dissolution process. Results these measurements correlated a semiempirical equation. For all systems, equation provided an accurate mathematical representation experimental data.
The reduction of podocyte injury is a key strategy in controlling proteinuria, which the main early clinical manifestation diabetic nephropathy (DN). Impaired autophagic flux primary mechanism responsible for DN. aim present study was to elucidate effect connexin 43 (Cx43) on impaired and explore its molecular action Sprague‑Dawley rats were administered streptozocin (STZ) construct DN animal model. Podocytes incubated media containing either buffer or high glucose (HG; 30 mM) variable time...