A5083883398- Cervical Cancer and HPV Research
- Virus-based gene therapy research
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Venomous Animal Envenomation and Studies
- Herpesvirus Infections and Treatments
- Immunotherapy and Immune Responses
- Bacteriophages and microbial interactions
- T-cell and Retrovirus Studies
- Poxvirus research and outbreaks
- Plant tissue culture and regeneration
- Clinical Laboratory Practices and Quality Control
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Blood properties and coagulation
- NF-κB Signaling Pathways
- Plant and Fungal Interactions Research
- Animal Disease Management and Epidemiology
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Erythrocyte Function and Pathophysiology
- Plant Genetic and Mutation Studies
- PI3K/AKT/mTOR signaling in cancer
- Glycosylation and Glycoproteins Research
- Cancer Immunotherapy and Biomarkers
The University of Queensland
2014-2024
Wenzhou Medical University
2015-2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2022
Translational Research Institute
2014-2021
Royal Brisbane and Women's Hospital
2010-2020
Princess Alexandra Hospital
2002-2014
QIMR Berghofer Medical Research Institute
2010-2011
In-Q-Tel
2008
Xi'an Jiaotong University
2005
Australian National University
1994-1995
Tumor-infiltrating immune cells (TIICs) play essential roles in cancer development and progression. However, the association of TIICs with prognosis colorectal (CRC) patients remain elusive. Infiltration was assessed using ssGSEA CIBERSORT tools. The analyzed 1,802 CRC samples date downloaded from GEO (https://www.ncbi.nlm.nih.gov/geo/) TCGA (https://gdc.cancer.gov/) databases. Three populations TIICs, including CD66b+ tumor-associated neutrophils (TANs), FoxP3+ Tregs, CD163+ macrophages...
Abstract Background SARS‐CoV‐2 has spread worldwide causing more than 400 million people with virus infections since early 2020. Currently, the existing vaccines targeting spike glycoprotein (S protein) of are facing great challenge from infection and its multiple S protein variants. Thus, we need to develop a new generation prevent Compared protein, nucleocapsid (N is conservative less mutations, which also plays vital role in viral infection. Therefore, N may have potential for developing...
Abstract Background Colposcopy is indispensable for the diagnosis of cervical lesions. However, its accuracy high‐grade squamous intraepithelial lesion (HSIL) at about 50%, and largely dependent on skill experience colposcopists. The advancement in computational power made it possible application artificial intelligence (AI) to clinical problems. Here, we explored feasibility AI precancerous cancerous colposcopic image recognition classification. Methods images were collected from 6002...
Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in head and neck with a complex etiology, such as environmental factors, genetic Epstein-Barr virus infection. The NOP2/Sun domain family, member 2 (NSUN2) methyltransferase m5C methylation modification that has been reported to be involved occurrence progression various tumors, but its role NPC remains unclear. In this study, we found NSUN2 was upregulated predicted poor prognosis for patients both GEO datasets our tissue...
Human papillomavirus 16 (HPV16) infection causes 50 % or more of cervical cancers in women. The HPV16 E7 oncogene is continuously expressed infected epithelium with its oncogenicity linked to cancer. protein an ideal target control HPV through T-cell-mediated immunity. Using E7-transgenic mouse keratinocytes (KCs–E7) investigate immune responses, we have shown previously that HPV16-encoded inhibits IFN-γ-mediated enhancement MHC class I antigen processing and T-cell-induced cell lysis. In...
Background: Cervical cancer induced by infection with human papillomavirus (HPV) remains a leading cause of mortality for women worldwide although preventive vaccines and early diagnosis have reduced morbidity mortality. Advanced cervical can only be treated either chemotherapy or radiotherapy but the outcomes are poor. The median survival advanced patients is 16.8 months. Methods: We undertook structural search peer-reviewed published studies based on 1). Characteristics programmed cell...
By establishing mouse primary keratinocytes (KCs) in culture, we were able, for the first time, to express papillomavirus major capsid (L1) proteins by transient transfection of authentic or codon-modified L1 gene expression plasmids. We demonstrate vitro and vivo that codon composition is part responsible differentiation-dependent protein KCs. mRNA was present similar amounts differentiated undifferentiated KCs transfected with genes had a half-life, demonstrating production...
// Xiangyang Xue 1, * , Bingbing Wang Wangqi Du Chanqiong Zhang 1 Yiling Song Yiqi Cai 2 Danwei Cen Ledan 3 Yirong Xiong Pengfei Jiang Shanli Zhu Kong-Nan Zhao Lifang Department of Microbiology and Immunology, Institute molecular virology immunology, Wenzhou Medical University, Wenzhou, China General Surgery, First Affiliated Hospital, Obstetrics Gynecology, Second These authors have contributed equally to this work Correspondence to: Zhang, email: wenzhouzlf@126.com Keywords: cervical...
Transforming growth factor beta (TGFβ) signalling is involved in both tumour suppression and progression. The mRNA expression levels of the TGFβ isoforms receptors breast tumours may have prognostic value clinical implications. TGFB1, TGFB2, TGFB3, TGFBR1 TGFBR2 were analysed primary adjacent normal tissues, associations with characteristics patients' overall relapse-free survival evaluated, using public gene microarray data from Cancer Genome Atlas (n = 520) Gene Expression Omnibus (four...
We evaluated the immunogenicity and efficacy of a candidate vaccine comprising major outer membrane protein (MOMP) multi-epitope Chlamydia trachomatis. A short gene derived from MOMP containing multiple T- B-cell epitopes was artificially synthesized. The recombinant plasmid pET32a(+) codon optimized constructed. Expression fusion Trx-His-MOMP in Escherichia coli confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis western blot analysis. Balb/c mice were inoculated with...
Sulphated polysaccharides with anti-thrombotic and anti-coagulant activities have been found in various marine biota. In this study, a previously characterised extract from blacklip abalone was fractionated by anion exchange chromatography (AEC), pooled (on sulphated polysaccharide basis) administered to Wistar rats via oral gavage (N = 8) for assessment as an therapeutic. To ensure that the preparation had activity prior administration, it assessed rat blood thromboelastography (TEG)...
ABSTRACT Saccharomyces cerevisiae protoplasts exposed to bovine papillomavirus type 1 (BPV-1) virions demonstrated uptake of on electron microscopy. S. cells looked larger after exposure BPV-1 virions, and cell wall regeneration was delayed. Southern blot hybridization Hirt DNA from DNA, which could be detected over 80 days culture at least 13 rounds division. Two-dimensional gel analysis showed replicative intermediates, confirming that the genome replicating within . Nicked circle, linear,...