A5100383261- Myofascial pain diagnosis and treatment
- Acupuncture Treatment Research Studies
- Telomeres, Telomerase, and Senescence
- Pain Mechanisms and Treatments
- Lysosomal Storage Disorders Research
- Adipose Tissue and Metabolism
- Cellular transport and secretion
- Genetics, Aging, and Longevity in Model Organisms
- Therapeutic Uses of Natural Elements
- Musculoskeletal pain and rehabilitation
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Bach Studies and Logistics Development
- Spinal Cord Injury Research
- Asthma and respiratory diseases
- Neuropeptides and Animal Physiology
- Traumatic Brain Injury and Neurovascular Disturbances
- Mitochondrial Function and Pathology
- Trace Elements in Health
- Carbohydrate Chemistry and Synthesis
- Glaucoma and retinal disorders
- Obstructive Sleep Apnea Research
- Glycosylation and Glycoproteins Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pluripotent Stem Cells Research
Hebei Medical University
2023-2025
Capital Medical University
2019-2025
APT Therapeutics (United States)
2021-2025
Zhejiang Center for Disease Control and Prevention
2025
Zhejiang Hospital
2025
First Affiliated Hospital of Hebei Medical University
2023-2025
Montreal Neurological Institute and Hospital
2025
McGill University
2025
Yangtze University
2024
Tianjin Medical University
2022-2024
Summary Mitochondrial dysfunction and oxidative stress have been implicated in cellular senescence, apoptosis, aging aging‐associated pathologies. Telomere shortening genomic instability also associated with replicative cancer. Here we show that mitochondrial leads to telomere attrition, loss, chromosome fusion breakage, accompanied by apoptosis. An antioxidant prevented loss cells dysfunctional mitochondria, suggesting reactive oxygen species are mediators linking instability. Further,...
The environmental contaminant arsenic causes cancer, developmental retardation, and other degenerative diseases and, thus, is a serious health concern worldwide. Paradoxically, also may serve as an anti-tumor therapy, although the mechanisms of its antineoplastic effects remain unclear. Arsenic exerts toxicity in part by generating reactive oxygen species. We show that arsenic-induced oxidative stress promotes telomere attrition, chromosome end-to-end fusions, apoptotic cell death. An...
BACKGROUNDOvarian aging is associated with declining numbers and quality of oocytes follicles. Oxidative stress by reactive oxygen species (ROS) contributes to somatic in general, also has been implicated reproductive aging. Telomere shortening involved aging, telomeres are particularly susceptible ROS-induced damage. Previously, we have shown that antioxidant N-acetyl-l-cysteine (NAC) effectively rescues embryos from telomere apoptosis vitro. Using mice as models, tested the hypothesis...
National Institutes of Health Stroke Scale certification is required for participation in modern stroke clinical trials and as part good care centers. A new training demonstration DVD was produced to replace existing videotapes. Previously, this DVD, with 18 patients representing all possible scores on 15 scale items, shown be reliable among expert users. The now the standard training, but videos have not been validated general (ie, nonexpert) users.We sought measure interrater reliability...
The quality of mitochondria in skeletal muscle is essential for maintaining metabolic homeostasis during adaptive stress responses. However, the precise control mechanism mitochondrial and its physiological impacts remain unclear. Here, we demonstrate that FUNDC1, a mediator mitophagy, plays critical role controlling as well homeostasis. Skeletal-muscle-specific ablation FUNDC1 mice resulted LC3-mediated mitophagy defect, leading to impaired energetics. This caused decreased fat utilization...
Pomaglumetad methionil (LY2140023 monohydrate) is a potent and highly selective agonist for the metabotropic glutamate mGluR2 mGluR3 receptors. We present results of pivotal clinical study H8Y-MC-HBBM assessing efficacy LY2140023 in improving symptoms as monotherapy patients with an acute exacerbation schizophrenia.Enrolled adult (ages 18-65) schizophrenia who had experienced within 2 weeks prior to entry. Patients (N = 1013) were randomized 2:2:2:1 treatment placebo, LY40 mg twice daily...
The purpose of this study was to explore the effects repeated low-level red-light (RLRL) therapy on structure and vasculature choroid retina in Chinese children with premyopia. This a single-center randomized clinical trial. A total 94 premyopia (− 0.50 D < spherical equivalent [SE] ≤ + 0.75 D) were randomly assigned either RLRL or control group. Follow-up visits planned at 1, 3, 6, 9, 12 months. Optical coherence biometry used measure axial length (AL) anterior segment parameters. Choroidal...
NIH Stroke Scale certification is required for participation in modern stroke clinical trials and as part of good care centers. The existing training videotapes, however, are more than 10 years old do not contain an adequate balance patient findings.After producing a new NIHSS demonstration DVD, we selected 18 patients representing all possible scores on 15 scale items DVD. Patients were divided into 3 groups 6 each, balanced lesion side, distribution item findings, total score. We sought to...
This study investigated the effects of phototherapy on serum BH4 levels, evoked potentials, and cognitive impairment in post-stroke depression patients. We conducted a prospective with 160 patients, randomly assigned to an experimental group receiving daily 40 min alongside routine treatment, control only treatment. Serum tetrahydrobiopterin (BH4) levels were measured via ELISA. Evoked potentials assessed using ERP recorder, depressive symptoms evaluated Hamilton Depression Scale (HAM-D),...
A forefront of the research on Alzheimer's disease (AD) is interaction amyloid β (Aβ) peptides with redox metal ions (e.g., Cu(II), Fe(III), and Fe(II)) biological relevance Aβ−metal complexes to neuronal cell loss homeostasis essential metals other cellular species. This work concerned kinetic mechanistic studies ascorbic acid oxidation reaction by molecular oxygen that facilitated Cu(II) Aβ(1−16), Aβ(1−42), aggregates Aβ(1−42). The rate was found linearly increase concentrations Aβ−Cu(II)...
<h3>Background</h3> Graves' disease is a female preponderant autoimmune illness and the contribution of X chromosome to its risk has long been appreciated. However, no X-linked susceptibility loci have indentified from recent genome-wide association studies (GWAS). <h3>Methods</h3> We re-examined data our GWAS for by including males that were previously excluded analyses. The analysed using logistic regression analysis sex as covariate, an additive method assuming inactivation, implemented...