A5024756328- Child and Animal Learning Development
- Schizophrenia research and treatment
- Celiac Disease Research and Management
- Primate Behavior and Ecology
- Autism Spectrum Disorder Research
- Cognitive Science and Mapping
- Electroconvulsive Therapy Studies
- Action Observation and Synchronization
- Bipolar Disorder and Treatment
- Language and cultural evolution
- Neuroendocrine regulation and behavior
- Cultural Differences and Values
- Microscopic Colitis
- Behavioral and Psychological Studies
- Hearing Impairment and Communication
- Treatment of Major Depression
- Helicobacter pylori-related gastroenterology studies
- Memory and Neural Mechanisms
- Human-Animal Interaction Studies
- Gastrointestinal disorders and treatments
- Psychology of Moral and Emotional Judgment
- Language, Discourse, Communication Strategies
- Literacy and Educational Practices
- Face Recognition and Perception
- Developmental and Educational Neuropsychology
Universidad Autónoma de Bucaramanga
2024-2025
University of St Andrews
2015-2024
Colby College
2019-2024
Carnegie Mellon University
2019-2024
KU Leuven
2023-2024
University of British Columbia
2023-2024
Nantes Université
2023-2024
California University of Pennsylvania
2023-2024
Air Force Medical University
2023-2024
University of California, Santa Cruz
2023-2024
Abstract Notch signaling has been extensively implicated in cell-fate determination along the development of immune system. However, a role for fully differentiated cells not clearly defined. We have analyzed expression protein family members during macrophage activation. Resting macrophages express Notch-1, -2, and -4, as well ligands Jagged-1 -2. After treatment with LPS and/or IFN-γ, we observed p38 MAPK-dependent increase Notch-1 mRNA levels. To study activation, forced transient...
'Theory of Mind' refers to the ability attribute mental states oneself and other people (Premack & Woodruff, 1978). This study examined extent which 'Self' 'Other' belief-attribution processes within Theory Mind (ToM) mechanism could be distinguished behaviourally, whether these separable components differentially related Executive Functioning (EF) abilities. A computerized false-belief task, utilizing a matched-design allow direct comparison self-oriented vs. other-oriented...
Atypical antipsychotics are widely used in bipolar mania. However, the efficacy of atypical depression has not been comprehensively explored.To evaluate olanzapine monotherapy patients with depression.Patients received (5-20 mg/day, n = 343) or placebo (n 171) for 6 weeks. The primary outcome was change from baseline to end-point Montgomery-Åsberg Depression Rating Scale (MADRS) total score. Secondary outcomes included: Clinical Global Impression - Bipolar Version (CGI-BP) scale, 17-item...
Pomaglumetad methionil (LY2140023 monohydrate) is a potent and highly selective agonist for the metabotropic glutamate mGluR2 mGluR3 receptors. We present results of pivotal clinical study H8Y-MC-HBBM assessing efficacy LY2140023 in improving symptoms as monotherapy patients with an acute exacerbation schizophrenia.Enrolled adult (ages 18-65) schizophrenia who had experienced within 2 weeks prior to entry. Patients (N = 1013) were randomized 2:2:2:1 treatment placebo, LY40 mg twice daily...
EXamining everolimus In a Study of Tuberous sclerosis 3 (EXIST-3) demonstrated significantly reduced seizure frequency (SF) with vs placebo. this study, we evaluate the long-term efficacy and safety for tuberous complex (TSC)-associated treatment-refractory seizures.After completion core phase, patients could enter an open-label extension phase receive (target exposure, 3-15 ng/mL) ≥48 weeks. Efficacy end points included change from baseline in average weekly SF expressed as response rate...
Noninvasive serologic tests have shown high diagnostic accuracy for celiac disease (CD) in selected populations. Our aim was to determine prospectively the performance of CD-related serology individuals undergoing intestinal biopsy because clinical suspicion small-bowel disorders.We enrolled 141 unselected consecutive adult patients attending a clinic. Patients underwent endoscopy and biopsy; serum samples were obtained at that time measurements anti-tissue transglutaminase (a-tTG), IgA IgG...
This article presents a tentatively “balanced” view (i.e., midway between lean and rich interpretations) of pointing behavior in infants apes, based upon the notion intentional reading without simultaneous attribution unobservable mental states. can account for complexity infant attributing multilayered mindreading to infants. It also ape pointing, which shares some complexities but departs from it other respects, notably its range motives focus regulation executive behavior. The explores...
Autism is a lifelong developmental condition that affects how people perceive the world and interact with others.Challenges typical social engagement, common in autism experience, can have significant negative impact on quality of life individuals families living autism.Recent advances sensing, intelligent, interactive technologies enable new forms assistive augmentative to support interactions.However, researchers not yet demonstrated effectiveness these long-term real-world use.This paper...
Children with autism have specific difficulties understanding complex mental states like thought, belief, and false belief their effects on behaviour. Such children benefit from focused teaching, where beliefs are likened to photographs-in-the-head. Here two studies, one seven participants 10, tested a picture- in-the-head strategy for dealing thoughts behaviour by teaching about cartoon thought-bubbles as device representing such states. This prosthetic led pass not only tests, but also...
When we compare human gestures to those of other apes, it looks at first like there is nothing much all. In adult humans, are thought be a window into the processes accompanying language, and sign languages equal spoken language with all its features. Some research firmly emphasises differences between apes; however, question about whether any commonalities rarely investigated, has mostly been confined pointing gestures. The gestural repertoires nonhuman ape species have carefully studied...
Human eye morphology is considered unique among the primates in that humans possess larger width/height ratios (WHR), expose a greater amount of visible sclera (SSI; width exposed eyeball/width iris), and critically, have white due to lack pigmentation. White amplifies gaze direction, whereas all-dark eyes apes are hypothesized conceal from others. This study examines WHR SSI (N = 13) gorillas 85) engaged direct averted gazes introduces qualitative assessment color evaluate variations The...
The screening and diagnosis of coeliac disease have been simplified by the advent new serological tools.To assess clinical utility a newly developed kit for antibodies to human recombinant tissue transglutaminase (hu-anti-tTG) in large population patients undergoing intestinal biopsy suspected disorders.We evaluated 426 serum samples from consecutive adult (250 untreated 176 individuals whom had excluded), obtained at time biopsy. Samples were tested immunoglobulin A (IgA) hu-anti-tTG...
Formal language theory has been extended to two-dimensional patterns, but little is known about pattern perception. We first examined spontaneous visual production by humans, gathered using a novel touch screen approach. Both creative and subsequent aesthetic ratings show that humans prefer ordered, symmetrical patterns over random patterns. then further explored pattern-parsing abilities in different human groups, compared them with pigeons. generated plane based on rules varying...
Article AbstractIntroduction: Results of controlled clinical trials should be confirmed through safety and effectiveness studies in nonselected patient cohorts treated according to routine practice. Method: Outpatients with schizophrenia (ICD-10 criteria) entered this prospective, naturalistic study when they received a new prescription for an antipsychotic drug. Treatment assignment was based on purely criteria, as the did not include any experimental intervention. Safety evaluated...
Clozapine is currently the treatment of choice for neuroleptic-resistant schizophrenia. Olanzapine a new antipsychotic drug that has shown efficacy against positive and negative symptoms schizophrenia, with minimal extrapyramidal side effects. However, effectiveness olanzapine not yet been reported among treatment-refractory schizophrenic patients.A total 25 patients (DSM-IV criteria) documented lack response to two conventional drugs entered this 6-week prospective, open-label trial 15...