Abstract: Regeneration deficiency is one of the main obstacles limiting effectiveness tissue-engineered scaffolds. To develop scaffolds that are capable accelerating regeneration, we created a heparin/chitosan nanoparticle-immobilized decellularized bovine jugular vein scaffold to increase loading capacity and allow for controlled release vascular endothelial growth factor (VEGF). The vascularization was evaluated in vitro vivo. functional nanoparticles were prepared by physical...

We explored the effects of progressive muscle relaxation (PMR) on anxiety, depression, and quality life (QOL) in patients with pulmonary arterial hypertension (PAH). One hundred thirty Han Chinese PAH were randomly assigned to a PMR group (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>65</mml:mn></mml:math>) control id="M2"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>65</mml:mn></mml:math>). In 12-week study duration, received...

A 34-year-old woman was referred to our hospital at 24+4 weeks of gestation for further evaluation two cystic masses in the fetal abdomen. The patient had a history antiphospholipid syndrome and receiving aspirin anticoagulation. No other medications were taken during organogenesis. Noninvasive DNA screening Down yielded negative results. Whole exome sequencing chromosome analysis revealed no abnormalities, there family congenital anomalies. upper pulsatile mass measured 41×35×30 mm located...

Small-diameter vascular grafts have a significant need in peripheral surgery and procedures of coronary artery bypass graft (CABG); however, autografts are not always available, synthetic perform poorly, allografts xenografts dilate, calcify, induce inflammation after implantation. We hypothesized that cross-linking decellularized xenogeneic would improve the mechanical properties biocompatibility reduce inflammation, degradation, calcification vivo. To test this hypothesis, bovine internal...

Monitoring the left atrial pressures (LAP) is an important perioperative management tool for maintaining adequate cardiac output. However, incorrect placement of LAP-monitoring catheter tip often leads to inherent risk. This study aimed evaluate length LAP in pediatric open-heart surgery and devise a simple formula predict ideal insertion based on correlated demographic clinical characteristics. We conducted retrospective cohort involving 79 infant patients aged ≤ 1 year who underwent right...

Coarctation of the aorta (CoA) is one more prevalent congenital heart diseases (CHD). The conventional treatment approach involves surgical correction coarctation. This procedure, however, can be associated with several complications, such as re-stenosis, aneurysm formation and pseudoaneurysm. One rare but significant complication left bronchial compression, which may result from anterior displacement thoracic or compression trachea by adherent tissue. We present a case 7-month-old...

Bioprosthetic heart valves (BHVs) used in clinics are fabricated via glutaraldehyde (GLUT) crosslinking, which results cytotoxicity and causes eventual valve calcification after implantation into the human body; therefore, average lifetime application of BHVs limited. To address these issues, most commonly method is modification with amino acids, such as glycine (GLY), proven to effectively reduce toxicity calcification. In this study, we l-glutathione (GSH) a new treatment based on...

Decellularization means and altering crosslinking approaches were two promising alternatives for glutaraldehyde fixation to biological tissues. Bovine jugular veins (BJVs) decellularized by a multi-step detergent–enzymatic extraction method, then photooxidatively crosslinked. Gross histological integrity of which was retained. Ultrastructures showed collagen fibrils elastic fibers, basement membrane free luminal surface. Mechanical strength test tissue protein assay demonstrated their...

Purpose: The absence of a complete endothelial cell layer is well-recognized reason leading to small-diameter tissue-engineered vascular graft failure. Here we reported multifunctional system consisting chitosan (CS), Arg-Glu-Asp-Val (REDV) peptide, heparin, and growth factor (VEGF) achieve sustained anti-thrombosis rapid endothelialization for decellularized photo-oxidized bovine internal mammary arteries (DP-BIMA). Methods: CS-REDV copolymers were synthesized via transglutaminase (TGase)...

Background: Cell therapy is a promising strategy for tissue regeneration. Key to this mobilization and recruitment of exogenous or autologous stem/progenitor cells by cytokines. However, there no effective cytokine delivery system available clinic application, in particular myocardial The aim study was develop novel that stable solution at physiological pH. Methods: Four groups self-assembled chitosan oligosaccharide/heparin (CSO/H) nanoparticles were prepared with various volume ratios...

Biventricular repair of double-outlet right ventricle with noncommitted ventricular septal defect is preferred, but previously developed surgical procedures are complicated and associated high mortality morbidity. We a technique using an intraventricular conduit to connect the aorta in this anomaly patients aged more than 2 years.Thirty-one (age 2-23 years; median, 5.4) underwent biventricular conduit. A 16-mm or 19-mm polytetrafluoroethylene (Gore-Tex; WL Gore & Associates, Flagstaff, Ariz)...

Abstract: Biocompatibility and biomechanical stability are two of the main obstacles limiting effectiveness vascular scaffolds. To improve biocompatibility these scaffolds, we created a heparin-nanomodified acellular bovine jugular vein scaffold by alternating linkage heparin dihydroxy-iron via self-assembly. Features were evaluated in vitro vivo. Heparin was firmly linked to formed nanoscale coatings around fibers scaffold, amount about 808 ± 86 µg/cm 2 (101 11 USP/cm ) per assembly cycle....

Pediatric primary cardiac tumors (PCTs) are rare. Its clinical features and prognoses not well defined. The management of asymptomatic patients with fibromas remains controversial.We aimed to examine our experience in surgical resection pediatric PCT, specific focuses on the large fibromas.This study included all children who underwent PCT institution between December 2008 June 2021. last follow-up was performed 1st August 26th, Kaplan-Meier method used estimate postoperative survival,...

Abstract Little is understood of the mechanisms involved in reducing pulmonary arterial wall thickness on recovery from hypertension and present study sought to clarify events that occur. Piglets were exposed hypobaric hypoxia for 3 days, either birth or days age, others 11 starting at days. All recovered room air up 6 Using light electron microscopy, artery thickness, relative contribution smooth muscle matrix, cell replication, apoptosis assessed after hypoxic exposure during exposure. In...

Anomalous origin of the right pulmonary artery from ascending aorta (AORPA) is a rare and potential fatal kind congenital heart disease. This study summarizes techniques outcomes 6 infants with AORPA who underwent surgical repair.Between November 2012 2014, received repair in Second Xiangya Hospital were included present study.Six (4 male, 66.7 %) median age 101.5 ± 70.0 days, body weight 4.13 0.62 kg at our institute. There no operative, in-hospital or follow-up deaths. Clinical symptoms...

Transcatheter aortic valve implantation (TAVI) has received much attention and development in the past decade due to its lower risk of complication infections compared a traditional open thoracotomy. However, current commercial transcatheter heart does not fully meet clinical needs; therefore, new biological materials must be found order these requirements. We have discovered type material, yak pericardium. This research studied extracellular matrix structure, composition, mechanical...

More than 200,000 patients with aortic diseases worldwide undergo surgical valve replacement each year, and transcatheter heart valves (THV) have been more widely used ever before. However, THV made by the glutaraldehyde (Glut) crosslinking method has disadvantage of being prone to calcification, which significantly reduces durability biomaterials. In this study, we applied a novel using ribose in for first time, can decrease calcification increase stability extracellular matrix (ECM). We...