A5090807692- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Head and Neck Cancer Studies
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Cancer Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Immune cells in cancer
- Reproductive System and Pregnancy
- Autophagy in Disease and Therapy
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- Photonic Crystals and Applications
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Phagocytosis and Immune Regulation
- Metastasis and carcinoma case studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Epigenetics and DNA Methylation
- Photonic and Optical Devices
- Cancer survivorship and care
- Cancer Mechanisms and Therapy
University of Electronic Science and Technology of China
2018-2025
Guangzhou Medical University
2025
State Key Laboratory of Respiratory Disease
2025
Sichuan University
2020-2025
West China Hospital of Sichuan University
2020-2025
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2018-2025
Fujian Provincial Hospital
2022-2025
Army Medical University
2014-2024
Southwest Hospital
2014-2024
Shandong University
2024
Abstract Neoadjuvant chemoimmunotherapy (NACI) has shown promise in the treatment of resectable esophageal squamous cell carcinoma (ESCC). The microbiomes patients can impact therapy response, and previous studies have demonstrated that intestinal microbiota influences cancer immunotherapy by activating gut immunity. Here, we investigated effects intratumoral on response with ESCC to NACI. Intratumoral signatures β-diversity were disparate predicted efficiency enrichment Streptococcus...
Cancer stem-like cells (CSLCs) acquire enhanced immune checkpoint responses to evade cell killing and promote tumor progression. Here we showed that signal regulatory protein γ (SIRPγ) determined CSLC properties evasiveness in a small population of lung adenocarcinoma (LUAD) cancer cells. A SIRPγhi displayed transmitted the escape through sustaining CD47 expression both SIRPγlo/- SIRPγ bridged MST1 PP2A facilitate dephosphorylation, resulting Hippo/YAP activation leading cytokine release by...
Abstract Background The identification of novel targets for recovering sorafenib resistance is pivotal Hepatocellular carcinoma (HCC) patients. Mitophagy the programmed degradation mitochondria, and likely involved in drug cancer cells. Here, we identified hyperactivated mitophagy essential resistance, core regulator gene ATAD3A (ATPase family AAA domain containing 3A) was down regulated hypoxia induced resistant HCC Blocking may restore sensitivity these cells provide a new treatment...
Hepatocellular carcinoma (HCC) acquires an immunosuppressive microenvironment, leading to unbeneficial therapeutic outcomes. Hyaluronan-mediated motility receptor (HMMR) plays a crucial role in tumor progression. Here, we found that aberrant expression of HMMR could be predictive biomarker for the immune suppressive microenvironment HCC, but mechanism remains unclear. We established −/− liver cancer mouse model elucidate HMMR-mediated dysregulated “don't eat me” signal. knockout inhibited...
Objective: Glioblastoma (GBM) is the most common primary malignant brain tumor regulated by numerous genes, with poor survival outcomes and unsatisfactory response to therapy. Therefore, a robust, multi-gene signature-derived model required predict prognosis treatment in GBM. Methods: Gene expression data of GBM from TCGA GEO datasets were used identify differentially expressed genes (DEGs) through DESeq2 or LIMMA methods. The DEGs then overlapped for analysis univariate multivariate COX...
Abstract Low quantum yield and aggregation‐mediated quenching are two concerns for fluorescence imaging. However, there not yet general means available addressing these issues. Herein, a viscosity confinement‐mediated antiaggregation strategy is established to enable the improved properties of entrapped fluorophores in dye‐encapsulation nanotechnology including yield, lifetime, photostability. To instantiate this strategy, solid DL‐menthol (DLM) introduced disperse indocyanine green (ICG)...
Abstract Peripheral nerve injury has seriously affected patient’s health and life. Schwann cells play an important role in peripheral regeneration. However, the effect of current tissue engineered scaffolds for promoting growth is still not as good that autologous graft. In this study, new developed three-dimensional gellan gum/starch (GG/ST) with various printing gap were prepared by 3D technology. Various physiochemical characterizations printed performed including morphology, rheological...
Abstract Aims Polypoid giant cancer cells (PGCCs) represent a unique subgroup of stem‐like cells, acting as critical factor in promoting the recurrence various solid tumors. The effect PGCCs on tumor malignancy glioma and its immune microenvironment remains unclear. Methods Bioinformatic analysis was performed to investigate relationship between M2 tumor‐associated macrophages (TAMs) infiltration survival glioblastoma (GBM) patients. spatial location TAMs GBM also investigated using Ivy...
The presence of multiple immunosuppressive targets and insufficient activation infiltration cytotoxic T lymphocytes (CTLs) allow tumor cells to escape immune surveillance disable anti-PD-1/PD-L1 immunotherapy. Nanobiotechnology-engineered autologous vaccines (ATVs) that were camouflaged by cell membrane (TCM) designed activate facilitate CTLs for killing the unprotected lung cells, consequently realizing sequential PDE5 was firstly screened out as a new target cancer in clinical practice....
Abstract Mitochondrial pyruvate carrier 1 (MPC1), a key factor that controls transportation in the mitochondria, is known to be frequently dysregulated tumor initiation and progression. However, clinical relevance potential molecular mechanisms of MPC1 lung adenocarcinoma (LAC) progression remain illustrated. Herein, was lowly expressed LAC tissues significantly associated with favorable survival patients LAC. Functionally, markedly suppressed stemness, invasion, migration vitro spreading...
Targeting mitochondria via nano platform emerged as an attractive anti-tumor pathway due to the central regulation role in cellar apoptosis and drug resistance. Here, a mitochondria-targeting nanoparticle (TOS-PDA-PEG-TPP) was designed precisely deliver polydopamine (PDA) photothermal agent alpha-tocopherol succinate (α-TOS) chemotherapeutic of tumor cells, which inhibits growth through chemo- photothermal- synergistic therapies. TOS-PDA-PEG-TPP constructed by coating PDA on surface TOS NPs...
Prostate cancer is a widespread form of that impacts men across the world. MRI plays pivotal role in detection and precise localization cancerous regions, aiding medical professionals devising effective treatment strategies for patients. As result, often used diagnosis prostate cancer. Our proposed method employs deep learning to achieve automatic segmentation single series, particularly T2-weighted imaging (T2WI). study utilized data from 133 patients at hospital, consisting 71 cases 62...
This study aimed to construct predictive models using five different machine learning algorithms for predicting 6-month mortality risk among home-based hospice patients with advanced cancer. population-based retrospective prognostic examined data from 7023 in a center. Various including logistic regression, random forest, XGBoost, support vector machine, and neural network were implemented this study. The model performance effectiveness assessed sensitivity, specificity, accuracy, the area...
Metastasis is a major cause of cancer therapy failure and mortality. However, targeting metastatic seeding colonization remains significant challenge. In this study, we identified NSD2, histone methyltransferase responsible for dimethylating 3 at lysine 36, as being overexpressed in tumors. Our findings suggest that NSD2 overexpression enhances tumor metastasis both vitro vivo. Further analysis revealed promotes by activating Rac1 signaling. Mechanistically, combines with activates Tiam1 (T...