A5041724163- Thyroid Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Cancer-related Molecular Pathways
- Head and Neck Anomalies
- Growth Hormone and Insulin-like Growth Factors
- Cancer, Lipids, and Metabolism
- Ultrasound and Hyperthermia Applications
- Cancer Risks and Factors
- Ophthalmology and Eye Disorders
- RNA modifications and cancer
- Medical Imaging Techniques and Applications
- Neuroendocrine Tumor Research Advances
- MRI in cancer diagnosis
- Cancer, Hypoxia, and Metabolism
- Genetic factors in colorectal cancer
- Radiomics and Machine Learning in Medical Imaging
- Glutathione Transferases and Polymorphisms
- Bone health and treatments
- Radiation Dose and Imaging
- Radiopharmaceutical Chemistry and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced X-ray and CT Imaging
- Ferroptosis and cancer prognosis
- Cancer Diagnosis and Treatment
Tianjin Medical University General Hospital
2016-2025
Tianjin Medical University
2021-2024
Beijing Obstetrics and Gynecology Hospital
2024
Capital Medical University
2024
Second Military Medical University
2012-2022
Eastern Hepatobiliary Surgery Hospital
2022
Vanderbilt University
2001-2021
Nanjing University
2021
Vanderbilt-Ingram Cancer Center
2020
Vanderbilt University Medical Center
2004-2020
Nitrate contamination of drinking water may increase cancer risk, because nitrate is endogenously reduced to nitrite and subsequent nitrosation reactions give rise N-nitroso compounds; these compounds are highly carcinogenic can act systemically. We analyzed incidence in a cohort 21,977 Iowa women who were 55–69 years age at baseline 1986 had used the same supply more than 10 (87% >20 years); 16,541 on municipal supply, remainder private well. assessed exposure from 1955 through 1988 using...
Objective This retrospective study aims to evaluate the therapeutic effect of varying dosages adjuvant radioactive iodine (RAI) therapy on intermediate-risk papillary thyroid carcinoma (PTC) patients. Methods involved a total 427 PTC patients, out which 202 received 3.7GBq dosage RAI, and 225 5.55GBq dosage. The evaluation assessing outcomes, number treatment cycles, successful remnant ablation rates in both dose groups, six months post-adjuvant RAI therapy. Univariate multivariate logistic...
Objective To evaluate changes of nuclear factor-kappa B (NF-κB) during radioiodine 131 (131I) therapy and whether NF-κB inhibition could enhance 131I-induced apoptosis in differentiated thyroid cancer (DTC) cells a synergistic manner. Methods Three human DTC cell lines were used. was achieved by using inhibitor (Bay 11-7082) or p65 siRNA transfection. Methyl-thiazolyl-tetrazolium assay performed for viability assessment. DNA-binding assay, luciferase reporter Western blot adopted to...
Abstract Background Clear cell renal carcinoma (ccRCC) is an immunologically and histologically diverse tumor. However, how the structural heterogeneity of tumor microenvironment (TME) affects cancer progression treatment response remains unclear. Hence, we characterized TME architectures ccRCC tissues using imaging mass cytometry (IMC) explored their associations with clinical outcome therapeutic response. Methods Using IMC, profiled landscape paracancerous tissue by measuring 17 markers...
At present, most of the targeted imaging based on insulin-like growth factor 1 receptor (IGF-1R) is for tumor research, and there no IGF-1R-targeted Graves' ophthalmopathy(GO). This study aims to develop a peptide probe, 99mTc-ZIGF1R:4551-GGGC, targeting IGF-1R, achieve specific in disease (GD) animal models exhibiting GO. 99mTc-ZIGF1R:4551-GGGC probe was synthesized using direct labeling method its efficiency assessed via instant thin-layer chromatography (ITLC). Western blot analysis...
We aimed to investigate Hydrogen Peroxide Inducible DNA Interstrand Cross-Linker (HP-ICL) as a targeted therapy for anaplastic thyroid cancer (ATC) due its higher H2O2 content compared normal cells. In vitro analysis included fluorescence microscopy levels, and exposure of ATC cells various HP-ICL concentrations followed by assessment cell viability, apoptosis, cycle, damage using MTT, flow cytometry, γH2AX assay. Protein levels related apoptosis the PI3K/AKT/mTOR pathway were measured...
Benzyl isothiocyanate (BITC), a natural compound abundant in cruciferous vegetables, plays an important role the chemoprevention of various human malignancies. However, mechanism by which BITC inhibits tumor cell growth is not fully understood. This study combined network pharmacology, molecular docking, cellular experiments, and mouse models to predict validate targets mechanisms treatment anaplastic thyroid carcinoma (ATC). A total 10 key ATC were selected for docking. The target genes...
Hepatic dysfunction is often observed in patients with Graves' hyperthyroidism. The aims of this study were to investigate the risk factors for hepatic and analyze efficacy 131I (radioactive iodine-131) treatment. In total, 2385 hyperthyroidism (478 males, 1907 females; age 42.8 ± 13.5 years) involved our study. Of these, 1552 cases received All clinical data retrospectively reviewed explore associated using logistic regression analysis. Furthermore, we thyroid liver function indices...
Objective We aimed to measure prevalence of sleep disturbance in patients with differentiated thyroid cancer (DTC) by calculating Pittsburgh Sleep Quality Index (PSQI), and compare these data benign nodules or normal participants. Methods Three groups participated this cross-sectional study. In the first group, 162 DTC received total thyroidectomy, then 131I therapy. The second group consisted 84 nodules, who partial thyroidectomy. third was 78 healthy control cases. PSQI used assess...
This study aimed to investigate the use of contrast-enhanced ultrasonography (CEUS) and time-intensity curves assess angiogenesis in cervical cancer.60 patients who were scheduled undergo radical surgery for biopsy-proven cancers underwent CEUS. Surgical tissue sections from 32 did not receive neoadjuvant chemotherapy analyzed with CD34 staining estimate intratumoral microvessel density (MVD). CEUS images maximum intensity (IMAX), rise time (RT), peak (TTP) mean transit time.Cervical lesions...
Abstract Anaplastic thyroid carcinoma (ATC) is a rare but highly aggressive cancer with poor prognosis. Killing cells by inducing DNA damage or blockage of repair promising strategy for chemotherapy. It reported that aldehyde-reactive alkoxyamines can capture the AP sites, one most common lesions, and inhibit apurinic/apyrimidinic endonuclease 1(APE1)-mediated base excision (BER), leading to cell death. Whether this be employed ATC treatment rarely investigated. The aim study exploit...
Purpose To quantify tumor blood flow by using contrast material–enhanced destruction-replenishment ultrasonography (US) to evaluate response different doses of an agent for antiangiogenic treatment in hepatoma-bearing mice, with histologic measurements microvascular density (MVD) as the reference standard. Materials and Methods Experiments were approved regional animal care committee. Mice bearing subcutaneous H22 hepatoma treated thalidomide, 100 mg/kg group B 200 C. Group A (control group)...
Abstract 131 I treatment is an important management method for patients with differentiated thyroid cancer (DTC). Unsuccessful ablation drastically affects the prognosis of patients. This study aimed to analyze potential predictive factors influencing achievement a disease-free status following first therapy. retrospective review included 315 DTC patients, and multiple were analyzed. Tumor size, pathological tumor stage, lymph node (LN) metastasis, distant American Thyroid Association...
To assess the efficacy of radioiodine therapy (RIT) and investigate prognostic factors for patients with pulmonary metastasis secondary to differentiated thyroid carcinoma (DTC) through a retrospective study. A total 80 radioactive iodine-131 (131I)-avid from DTC treated 131I 2007 2014 at our institution entered Treatment response was mainly measured by two parameters: serum thyroglobulin (Tg) levels post-therapeutic whole-body scan (WBS). variables were assessed statistical significance...
Abstract Genetic mutations play important roles in not only development of papillary thyroid carcinoma (PTC) but also determination its properties. The radioactive iodine refractory (RAIR) state is a harbinger poor outcomes for PTC. We used various statistical models to investigate the significance TERT promoter, BRAF , and RAS distinguishing RAIR their associations with 131 I uptake. Mutations were examined primary lesions 33 cases 34 age‐ sex‐matched I‐treated disease‐free status....
Hepatic function injury is one of the common complications hyperthyroidism (mainly Graves’ disease), which affects choice treatment and curative rate. Our goal was to describe clinical biochemical patterns in patients suffering from disease (GD) hepatic determine influential factors. A cohort 1 070 who received <sup>131</sup>I were studied. Many examinations performed before therapy, such as: 24-h radioactive iodine uptake thyroid (RAIU<sub>24</sub> <sub>h</sub>) serum-free triiodothyronine...
Radioactive iodine (RAI) is considered to be related with hematologic changes. This study aimed evaluate influence of the first RAI ablation on peripheral complete blood count (CBC) in patients differentiated thyroid cancer (DTC). Data CBC at baseline and 6 months after were obtained 385 DTC approximately 3700 MBq 131I (ranging 2220–7585 MBq). Further comparison was done 196 1-month postablation data available. Routine examinations performed determine impact white cell (WBC), red (RBC),...