A5032862669- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- Phagocytosis and Immune Regulation
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Renal and related cancers
- Urologic and reproductive health conditions
- Cancer, Lipids, and Metabolism
- Urinary and Genital Oncology Studies
- Esophageal Cancer Research and Treatment
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- Genital Health and Disease
- Pancreatic and Hepatic Oncology Research
- Multiple and Secondary Primary Cancers
- Urological Disorders and Treatments
- Carcinogens and Genotoxicity Assessment
- Healthcare and Venom Research
- Mycotoxins in Agriculture and Food
- Nutrition and Health in Aging
- Genetic factors in colorectal cancer
Sichuan University
2014-2025
West China Hospital of Sichuan University
2010-2025
West China Medical Center of Sichuan University
2024
Jiangxi University of Traditional Chinese Medicine
2024
Yahoo (United Kingdom)
2023
Creative Commons
2023
The First People's Hospital of Guiyang
2023
Zunyi Medical University
2022
Guangdong Provincial People's Hospital
2020-2021
Center for Disease Control
2016-2021
Abstract Sarcopenia is a condition characterized by progressive and generalized loss of skeletal muscle mass function. In this study, we used cross-sectional study with 1090 community-dwelling Chinese citizens aged 60 years older to evaluate the association type 2 diabetes mellitus (T2DM) risk sarcopenia pre-sarcopenia. was defined using Asian Working Group for (AWGS) criteria that include both function/physical activity. Pre-sarcopenia as having low index but normal muscle/physical The...
Abstract Fumonisin B1 (FB1) is reportedly the causative agent of several animal mycotoxicoses and has etiologically been linked to human oesophageal liver cancer in certain areas South Africa China. To study a possible relationship between exposure FB1 risk, current status contamination food samples Huaian Fusui, where incidences are amongst highest China, was investigated. A total 259 corn were collected from individual households five villages different townships during December 2001 2002,...
Abstract Aflatoxins and fumonisins are ubiquitous foodborne toxicants the co-occurrence of these mycotoxins in human foods represents a significant public health concern, which has been strongly associated with aflatoxicosis, neural tube defects, as well many types primary cancers. In this study co-contamination aflatoxin B1 (AFB1) fumonisin (FB1) food dietary exposure was investigated residents three different areas China. A total 209 samples were measured for AFB1 FB1. The median levels...
Abstract Metabolic reprogramming plays an important role in kidney cancer. We aim to investigate the causal effect of 249 metabolic biomarkers on cancer from population-based data. This study extracts data previous genome wide association studies with large sample size. The primary endpoint is random-effect inverse variance weighted (IVW). After completing times two-sample Mendelian randomization analysis, those significant metabolites are included for further sensitivity analysis. According...
Fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC) is a rare yet highly lethal kidney cancer. To deepen our understanding of FH-deficient RCC, we conduct comprehensive integrated genomic study. We analyze the association FH alteration patterns with tumor heterogeneity and develop CpG site-specific methylation signature for precise identification RCC. Transcriptomic analysis unveils three distinctive molecular subtypes characterized by enrichment immune/Angiogenic/Stromal...
Continuous exposure to various environmental carcinogens and genetic polymorphisms of xenobiotic-metabolizing enzymes (XME) are associated with many types human cancers, including esophageal squamous cell carcinoma (ESCC). Huaian, China, is one the endemic regions ESCC, but fewer studies have been done in characterizing risk factors ESCC this area. The aims study evaluate etiological roles demographic parameters, food-borne exposure, XME formation investigate possible gene-gene...
Abstract Oxidative stress is involved in many types of DNA damage, e.g., resulting 8‐hydroxyguanine adducts. Since a human counterpart exists for the yeast gene OGG1 ( hOGG1 ) encoding an enzyme that repairs 8‐hydroxyguanine, its polymorphism, Ser 326 Cys, might have potential as genetic marker cancer susceptibility. To investigate association with stomach risk and possible interactions environmental factors, we conducted case‐control study 101 cases 198 controls using PCR‐single‐strand...
Cancer is a major public health burden both globally and in China. The most common cancer-related deaths China are attributable to cancers of the lung, liver, stomach, esophagus. Previous epidemiologic studies on cancer have often been limited by small sample sizes, inconsistent measurements, lack precise accurate data. Jiangsu Four Cancers (JFC) Study population-based case–control study carried out an effort obtain consistent high-quality data investigate life style, behavioral,...
Levels of serum and urinary sphinganine (Sa) sphingosine (So), the Sa/So ratio, urinary-free fumonisin B(1) (FB(1)) were determined in a cross-sectional study consisting 43 adults Huaian 34 Fusui, China. Home-produced corn had 100% contamination with FB(1). There 93.0% (40/43) subjects 52.9% (18/34) Fusui daily FB(1) intakes greater than 2 microg kg(-1) body weight, which showed significant difference (p < 0.01). ratio not correlated levels dietary exposure. The median level (0.41, range =...
A novel systemic immune-inflammation index (SII), based on the neutrophils, lymphocytes and platelet counts, is associated with prognosis of several cancers. The present study evaluates prognostic significance SII in non-metastatic renal cell carcinoma (RCC).The retrospectively reviewed medical record patients RCC who underwent nephrectomy between 2010 2013. Receiver operating characteristic (ROC) curve analysis was performed to identify optimal cut-off value. In addition, propensity score...
Abstract Germline mutations in MSH2 , MLH1 E‐cadherin and MutY ( MYH ) genes have been implicated the occurrence of gastric cancer (GC). Epidemiological investigation was performed by recruiting patients with GC onset during 2002 Jiangsu province, China. We identified suspected hereditary based on either family history or at early ages. screened germline variations 101 coding sequences polymerase chain reaction‐denaturing high‐performance liquid chromatography (PCR‐DHPLC) analysis DNA...
Although tobacco smoking has been reported as a risk factor for liver cancer, few studies have specifically explored the association among Chinese females and potential interaction between other factors. A population‐based case–control study was conducted 2,011 cancer cases 7,933 healthy controls were enrolled in Jiangsu, China from 2003 to 2010. Epidemiological data collected, serum hepatitis B surface antigen (HBsAg) anti‐HCV antibody measured. Unconditional logistic regression used...
Although the major risk factors for liver cancer have been established, preventive not fully explored. We evaluated association between raw garlic consumption and in a large population-based case-control study Eastern China. The was conducted Jiangsu, China, from 2003 to 2010. A total of 2011 incident cases 7933 randomly selected population-controls were interviewed. Epidemiological data including intake other exposures collected, serum markers hepatitis B virus (HBV) C (HCV) infection...
Abstract Background Consumption of moldy food has previously been identified as a risk factor for esophageal squamous cell carcinoma (ESCC) in high-risk countries; however, what contributing roles these dietary carcinogenic mycotoxins play the etiology ESCC are largely unknown. Methods A mycotoxin biomarker-incorporated, population-based case-control study was performed Huaian area, Jiangsu Province, one two areas China. Exposure biomarkers aflatoxins (AF) and fumonisins (FN) were...