A5081628154- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Inflammatory Biomarkers in Disease Prognosis
- Epigenetics and DNA Methylation
- Urological Disorders and Treatments
- Urinary Bladder and Prostate Research
- Urologic and reproductive health conditions
- Renal cell carcinoma treatment
- Glycosylation and Glycoproteins Research
- Esophageal Cancer Research and Treatment
- Cancer, Lipids, and Metabolism
- Hormonal and reproductive studies
- Colorectal Cancer Screening and Detection
- Advanced Proteomics Techniques and Applications
- 3D Printing in Biomedical Research
- MRI in cancer diagnosis
- Renal and Vascular Pathologies
- Proteins in Food Systems
- Pancreatitis Pathology and Treatment
- Cancer Research and Treatments
- Estrogen and related hormone effects
- Mass Spectrometry Techniques and Applications
Sichuan University
2017-2025
West China Hospital of Sichuan University
2017-2025
State Key Laboratory of Biotherapy
2021
Chengdu University
2020
Zhejiang University of Science and Technology
2020
Abstract Purpose: Fumarate hydratase–deficient renal cell carcinoma (FH-deficient RCC) is a rare but lethal subtype of RCC. Little known about the genomic profile FH-deficient RCC, and therapeutic options for advanced disease are limited. To this end, we performed comprehensive genomics study to characterize epigenomic features Experimental Design: Integrated genomic, epigenomic, molecular analyses were on 25 untreated primary RCCs. Complete clinicopathologic follow-up data these patients...
Cisplatin-based chemotherapy remains the primary treatment for unresectable and metastatic muscle-invasive bladder cancers (MIBCs). However, tumors frequently develop chemoresistance. Here, we established a orthotopic MIBC mouse model with gene-edited organoids to recapitulate full course of in patients. We found that partial squamous differentiation, called semi-squamatization, is associated acquired chemoresistance both mice human MIBCs. Multi-omics analyses showed cathepsin H (CTSH)...
Background Bladder cancer with high expression of human epidermal growth factor receptor-2 (HER2) is related to pathological malignancy and poor prognosis. The standard care for muscle-invasive urothelial bladder (MIBC) neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC) pelvic lymph node dissection. For HER2-positive MIBC, the efficacy cisplatin-based NAC unsatisfactory, adverse reactions are inevitable or even intolerable. New regimens higher efficiency lower toxicity need...
Abstract The tumor microenvironment is associated with various progressions, including cancer metastasis, immunosuppression, and sustained growth. Tumor‐associated macrophages (TAMs) are considered an indispensable component of the microenvironment, participating in progression remodeling creating compounds to regulate activities. This study aims observe enriched TAMs tissues during bladder development, which markedly facilitated proliferation cells promoted growth vivo. We determined that...
Abstract Purpose Testosterone plays a crucial role in males, and the deficiency of testosterone leads to multiple adverse health conditions. Klotho is recently discovered protein encoded by antiaging gene klotho . Both levels change with aging, so relationship between them worth exploring. The purpose this study was investigate whether total associated serum U.S. males aged 40–79 years. Methods Included were 3750 male participants from 2011 2016 National Health Nutrition Examination Survey,...
Site-specific N-glycosylation characterization requires intact N-glycopeptide analysis based on suitable tandem mass spectrometry (MS/MS) method. Electron-transfer/higher-energy collisional dissociation (EThcD), stepped collision energy/higher-energy (sceHCD), higher-energy dissociation-product-dependent electron-transfer (HCD-pd-ETD), and a hybrid fragmentation method EThcD-sceHCD have emerged as valuable approaches for glycoprotein analysis. However, each of them incurs some compromise,...
Abstract Background To retrospectively investigate the clinical characteristics, initial treatment, relapse, therapy outcome, and prognosis of Chinese patients with primary testicular lymphoma (PTL) through analysis cases our institute. Methods From December 2008 to July 2018, all PTL were included in this study. Kaplan-Meier method was used estimate PFS OS. The Cox proportional hazards model compare survival times for groups differing terms laboratory parameters. Results All 28 (24 DLBCL,...
786 Background: The “bladder-sparing” trimodal therapy (TMT) has gained popularity among selected patients with muscle-invasive bladder cancer (MIBC) who are either unfit for or decline radical cystectomy (RC). This Phase 2 study aimed to evaluate the bladder-sparing efficacy of neoadjuvant chemotherapy combined tislelizumab, followed by radiotherapy high-risk, locally advanced MIBC, were considered as non-ideal candidates treatment (Trial registration number: ChiCTR2100045213). Methods:...
795 Background: To evaluate the safety and efficacy of RC48-ADC, a humanized anti-HER2 antibody conjugated with monomethyl auristatin E, tislelizumab, PD-1 antibody, as novel neoadjuvant treatment combination in patients HER2 positive locally advanced muscle-invasive bladder cancer (MIBC). The study design has been presented at 2022 ESMO Asia meeting, preliminary results will be reported this time. Methods: This is Ib/II, multi-center, open-label, single-arm (ChiECRCT20210564). Patients...
The serum prostate-specific antigen (PSA) testing is widely used for prostate cancer (PCa) screening but suffers from poor specificity, leading to unnecessary biopsies and overtreatment. significant potential of extracellular vesicles (EVs) in diagnosis has driven the development efficient methods isolate identify EV biomarkers large-scale clinical samples. Here, we systematically evaluate five commonly isolation techniques through proteomic profiling plasma-derived EVs, endorsing TiO2-based...
The majority of clear cell renal carcinomas (ccRCCs) are caused by an accumulation hypoxia‑inducible factor (HIF) and the overexpression downstream genes in response to von Hippel‑Lindau (VHL) gene becoming inactivated. In present study, our hypothesis was that BNIP3, a positioned HIF, would be expressed at higher level ccRCC; however, instead, lower levels BNIP3 expression were identified RCC tumor tissues compared with adjacent non‑tumor tissues. These changes associated VHL, HIF vascular...
Glycoproteins are involved in a variety of biological processes. More than one-third the plasma protein biomarkers tumors approved by FDA glycoproteins, and could improve diagnostic specificity and/or sensitivity. Therefore, it is great significance to perform systematic characterization N-glycoproteome. In previous studies, we developed an integrated method based on combinatorial peptide ligand library (CPLL) stepped collision energy/higher energy collisional dissociation (sceHCD) for...
Urothelial carcinoma (UC) is the most common type of cancer bladder and upper urinary tract, characterized by a high risk recurrence progression. Urine fluorescence in situ hybridization (FISH) technique that detects genetic aberrations exfoliated cells urine, with specific probes for chromosomes 3, 7 17 p16 gene. To evaluate diagnostic value FISH UC, 119 patients from November 2010 to June 2012 suspected UC were recruited into prospective, cross‑sectional study followed up 12‑30 months....