A5088329188- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Per- and polyfluoroalkyl substances research
- Analytical chemistry methods development
- Analytical Chemistry and Chromatography
- Synthesis and Biological Evaluation
- Air Quality and Health Impacts
- Uterine Myomas and Treatments
- Acute Myeloid Leukemia Research
- Carcinogens and Genotoxicity Assessment
- Endometriosis Research and Treatment
- Head and Neck Cancer Studies
- Advanced Chemical Sensor Technologies
- Biopolymer Synthesis and Applications
- Metabolomics and Mass Spectrometry Studies
- Atmospheric chemistry and aerosols
- RNA Interference and Gene Delivery
- Transcranial Magnetic Stimulation Studies
- Chemical Analysis and Environmental Impact
- Metabolism and Genetic Disorders
- Gynecological conditions and treatments
- Heavy Metal Exposure and Toxicity
- Forensic Toxicology and Drug Analysis
- Cardiovascular Health and Disease Prevention
- Vitamin D Research Studies
Sichuan University
2016-2025
Jilin University
2018-2025
West China Medical Center of Sichuan University
2008-2024
Beijing University of Agriculture
2024
Affiliated Hospital of Southwest Medical University
2024
First Affiliated Hospital of Sichuan Medical University
2024
Jiangsu University
2022
Affiliated Hospital of Jiangsu University
2022
Renmin Hospital of Wuhan University
2021
Dalian Medical University
2008-2021
Although previous studies investigated the potential adverse effects of endocrine-disrupting chemicals (EDCs) on biological age acceleration and aging-related diseases, mixed effect multiple types EDCs acceleration, including its underlying mechanism, remains unclear. Data from National Health Nutrition Examination Survey (NHANES) were used to analyze measures, Klemera-Doubal method (KDM-BA), phenotypic age, homeostatic dysregulation (HD). Weight quantile sum (WQS) regression was performed...
Abstract Purpose Testosterone plays a crucial role in males, and the deficiency of testosterone leads to multiple adverse health conditions. Klotho is recently discovered protein encoded by antiaging gene klotho . Both levels change with aging, so relationship between them worth exploring. The purpose this study was investigate whether total associated serum U.S. males aged 40–79 years. Methods Included were 3750 male participants from 2011 2016 National Health Nutrition Examination Survey,...
Immunohistochemical distribution and cellular localization of neurotrophins was investigated in adult monkey brains using antisera against nerve growth factor (NGF), brain-derived neurotrophic (BDNF), neurotrophin-3 (NT-3), neurotrophin-4 (NT-4). Western blot analysis showed that each antibody specifically recognized appropriate bands ∼14.7 kDa, 14.2 13.6 14.5 for NGF, BDNF, NT-3, NT-4, respectively. These positions coincided with the molecular masses studied. Furthermore, sections exposed...
Phosphodiesterase type 5 (PDE5) inhibitors are first-line therapy for pulmonary arterial hypertension (PAH) and erectile dysfunction. As a continuing work to improve the terminal half-lives oral bioavailabilities of our previously reported 4(3H)-pyrimidones, pharmacokinetics-driven optimization focusing on substituent is described. Two major congeneric series aminosulfonylphenylpyrimidones acylaminophenylpyrimidones, were designed, synthesized, pharmacologically assessed in vitro vivo. Among...
Biological age (BA) is considered a better predictor of aging than chronological (CA). BA acceleration was defined as the disparity between and CA. However, there has been inconclusive evidence on whether might be reversed by increased total testosterone (TT). The goal this cross-sectional study to investigate relationship TT acceleration. Klemera Doubal method biological (KDM-BA) employed an indicator in study. This involved participants three ancestries from five cohorts, including...
ABSTRACT A growing concern has been raised about human exposure to phthalates and bisphenols, while data is limited regarding the accumulation of these endocrine disrupting chemicals at target tissue. In this study, a novel, simple, sensitive method was successfully developed for simultaneous determination nine phthalate monoesters bisphenols in prostate tissue samples. solid–liquid extraction procedure applied following ultra‐high performance liquid chromatography tandem mass spectrometry...
High-temperature-induced early bolting poses a pressing challenge in annual leaf lettuce cultivation. ABF transcription factors, or ABA-responsive element binding are crucial components of the ABA signalling pathway. In this study, we identified 8 members gene family lettuce, categorising them into groups A, B, and C through phylogenetic analysis. All LsABFs exhibited conserved domain, RMIKNRESAARSRARKQAY (Bzip_plant_BZIP46), as revealed by multiple sequence alignment. A total 1242...
A fast, simple and environmentally friendly method to determine nicotine cotinine in urine has been developed using dispersive liquid–liquid microextraction based on solidification of floating organic droplet (DLLME-SFO) with a binary mixed extractant as the pretreatment high performance liquid chromatography an ultraviolet detector (HPLC-UVD) analysis system. The samples were extracted solvent undecanol CHCl3 (v/v = 1 : 1) during DLLME-SFO procedure. employment had significantly improved...
Sublethal bactericidal antibiotics promote the formation of multidrug-tolerant persisters. Clinically, serum drug concentration increases gradually and reaches peak level with high killing efficiency some time after administration. This study aimed to investigate if initial low antibiotic would persister in Klebsiella pneumoniae, an increasingly important nosocomial pathogen. Time-dependent killings K. pneumoniae by different types were conducted determine existence Killing experiments...
A method of binary mixed solvent-SD-DLLME with GC-MS/MS was developed for the determination PAHs in water samples.
Air pollution is a major public health challenge in the highly urbanized megacities of China. However, knowledge on exposure to ambient unregulated air pollutants such as black carbon (BC) and ultrafine particles (UFP) among Chinese population, especially urban high school students who may have variable time-activity patterns, scarce. To address this, personal exposures BC UFP (aged 17 18) Chengdu, China were measured at 1-min intervals via portable samplers. Monitoring lasted for 2...
To study on effects of Lichong decoction expression apoptosis-controlling genes, Bcl-2 and Bcl-2-associated X protein (Bax) mRNAs in hysteromyoma tissue the model rat. Fifty Wistar female rats were randomly divided into a normal group, Guizifuling capsule group Mifepristone group. The rat was established by intraperitoneal injection exogenous estrin progestogens. Pathological examination uterine tissue, coefficient transverse diameter made under optic microscope expressions Bax groups...