A5071105935- Epigenetics and DNA Methylation
- Vitamin D Research Studies
- Genetic Syndromes and Imprinting
- Magnesium in Health and Disease
- Toxic Organic Pollutants Impact
- Trace Elements in Health
- Genetic Associations and Epidemiology
- Birth, Development, and Health
- Per- and polyfluoroalkyl substances research
- Heavy Metal Exposure and Toxicity
- Diet and metabolism studies
- Therapeutic Uses of Natural Elements
- Ultrasound in Clinical Applications
- Sepsis Diagnosis and Treatment
- Bone and Joint Diseases
- Nutritional Studies and Diet
- Sex and Gender in Healthcare
- Parathyroid Disorders and Treatments
- Phosphodiesterase function and regulation
- Hemodynamic Monitoring and Therapy
- Congenital heart defects research
- Liver Disease Diagnosis and Treatment
- Air Quality and Health Impacts
- Selenium in Biological Systems
- Single-cell and spatial transcriptomics
Institute of Oncology Research
2025
Sichuan University
2024-2025
West China Hospital of Sichuan University
2024-2025
Second Affiliated Hospital of Guangzhou Medical University
2021-2024
Guangzhou Medical University
2021-2024
Broad Institute
2024
Third Affiliated Hospital of Guangzhou Medical University
2022-2024
West China Medical Center of Sichuan University
2024
Guangdong Provincial People's Hospital
2024
Key Laboratory of Guangdong Province
2024
Introduction: Circulating vitamin D concentrations have been associated with the risk of type 2 diabetes (T2D). Magnesium has also reported to be lower T2D risk. Besides, magnesium is an essential cofactor for activation. However, effect dietary intake on association between and not studied comprehensively. Therefore, we designed this cross-sectional study assess modification T2D. Research Design Methods: The present analyzed data from National Health Nutrition Examination Survey (NHANES)...
Loss-of-function mutations in ZMYM2 are associated with an increased risk of schizophrenia (SCZ) and neurodevelopmental disorders (NDD). interacts proteins involved histone modification gene regulation, including LSD1 ADNP; however, its specific roles the brain remain poorly understood. In this multi-omics study, we demonstrate that heterozygous knockout Zmym2 mice results widespread disturbances expression affecting diverse molecular pathways, those related to modifications neuronal...
Schizophrenia is a severe mental illness with high heritability, but its underlying mechanisms are poorly understood. We meta-analyzed large-scale brain transcriptomic data from mice harboring individual loss-of-function mutations in seven schizophrenia risk genes (Akap11, Dagla, Gria3, Grin2a, Sp4, Srrm2, Zmym2). While all studied regions were affected, the striatum and thalamus emerged as key of convergence. Striatum showed downregulation synapse- oxidative phosphorylation-related gene...
A-Kinase Anchoring Protein 11 (AKAP11) is a shared genetic risk factor for schizophrenia and bipolar disorder, yet its role in the brain remains poorly understood. Through multi-omic analysis of Akap11 mutant mouse brains cultured astrocytes, we identified significant transcriptomic, proteomic, metabolomic alterations. Key findings include upregulation cholesterol fatty acid metabolic pathways, accumulation lipid species such as cholesteryl esters, triacylglycerols, ceramides,...
Noncanonical genomic imprinting can cause biased expression of one parental allele in a tissue; however, the functional relevance such biases is unclear. To investigate ethological roles for noncanonical dopa decarboxylase (Ddc) and tyrosine hydroxylase (Th), we use machine learning to decompose naturalistic foraging maternal paternal mutant heterozygous mice. We uncover distinct versus alleles on foraging, where affect sons while daughters are under allelic control. Each controls specific...
Although the association between blood pressure and vitamin D has been well studied, effects of dietary magnesium intake on this relationship are still unclear. Thus, study aimed to determine pressure.The present analyzed data from continuous National Health Nutrition Examination Survey (NHANES) 2007-2014. We included 8,799 participants aged 20 years or older. Multivariable linear regression was performed assess systolic (SBP) diastolic (DBP). Dietary stratified by low (<299 mg/d) high (≥299...
Background: the optimal timing of Transthoracic echocardiography (TTE) performance for patients with septic shock remains unexplored. Methods: a retrospective cohort study included in MIMIC-Ⅲ database. Risk-adjusted restricted cubic splines modeled 28-day mortality according to time elapsed from ICU admission receive TTE. The cut point when smooth curve inflected was selected define early and delayed group. We applied propensity score matching (PSM) ensure our findings were reliable. Causal...
Studies in recent years have shown that high uric acid causes harm to the human body, which has become a serious public health problem. Elevated serum been be associated with obesity, but relationship between BMI and (UA) remains controversial. Although association UA well studied, effect of phosphorus levels vivo on this unclear. This study aimed determine two.
ABSTRACT Protein-truncating variants in GRIA3 (encoding the GluA3/GluR3 subunit of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors) are associated with substantially increased risk schizophrenia (SCZ). Here we characterized Gria3 mutant mice carrying a protein-truncating mutation that mimics SCZ-associated variant. Transcriptomic analysis revealed activity-regulated genes downregulated cortical regions, while immune and glia-related pathways exhibit...
Insulin resistance, a pathological response to insulin hormone in insulin-dependent cells, is characterized by the presence of high glucose and concentrations. The homeostasis model resistance (HOMA-IR) one most used indexes estimate assessing fasting levels. An association was observed between vitamin D levels which varied different ethnic groups, there some evidence that supplementation could contribute improvement resistance. This study assessed 25-hydroxyvitamin (25[OH]D) concentration...
SUMMARY Dopa decarboxylase (DDC) regulates the synthesis of monoaminergic neurotransmitters and is linked to psychiatric metabolic disorders. Ddc exhibits complex genomic imprinting effects that have not been functionally studied. Here, we investigate different noncanonical at cellular level with a focus on . Using allele-specific reporter mice, found dominant expression maternal allele in subpopulations cells 14 52 brain regions, paternal or adrenal cell subpopulations. Maternal versus null...
Most genes in a diploid organism are thought to be expressed and regulated equally by the two parental alleles. However, subset of referred as monoallelically-expressed preferentially only on maternal or paternal allele. Monoallelically-expressed include imprinted genes, which express either allele p referentially, well random monoallelic that choose one at random. Examples vivo X-linked females, immunoglobulins B cells, clustered protocadherins, olfactory receptors. these examples generally...
Abstract IntroductionAlthough the association between blood pressure and vitamin D has been well studied, effects of dietary magnesium intake on this relationship are still unclear. Thus, study aimed to determine pressure.Research design methodsThe present analyzed data from continuous NHANES 2007-2014. We included 8799 participants aged 20 years or older. Multivariable linear regression was performed assess systolic (SBP), diastolic (DBP). Dietary stratified by low (<299mg/d), high...