A5072707998- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- Plant Molecular Biology Research
- DNA Repair Mechanisms
- Aerosol Filtration and Electrostatic Precipitation
- Effects and risks of endocrine disrupting chemicals
- Carcinogens and Genotoxicity Assessment
- Drug Transport and Resistance Mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Advanced Computational Techniques and Applications
- Chalcogenide Semiconductor Thin Films
- Genomics and Phylogenetic Studies
- Metabolomics and Mass Spectrometry Studies
- Advanced Sensor and Control Systems
- Advanced Semiconductor Detectors and Materials
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
- Smart Materials for Construction
- Pharmaceutical and Antibiotic Environmental Impacts
- RNA modifications and cancer
- Viral Infections and Immunology Research
Shenzhen Institutes of Advanced Technology
2021-2025
State Key Laboratory of Synthetic Chemistry
2024-2025
Mayo Clinic in Arizona
2025
Chongqing Jiulongpo People's Hospital
2025
Qingdao University
2023-2024
Affiliated Hospital of Qingdao University
2023-2024
Northwestern Polytechnical University
2024
Fourth Affiliated Hospital of Guangxi Medical University
2024
Chinese Academy of Sciences
2007-2023
Institute of Physics
2023
The G-rich strand of human telomeric DNA can fold into a four-stranded structure called G-quadruplex and inhibit telomerase activity that is expressed in 85−90% tumor cells. For this reason, telomere quadruplex emerging as potential therapeutic target for cancer. Information on the physiological environment important structure-based drug design targeting quadruplex. Recent studies have raised significant controversy regarding exact formed by relevant environment. Studies crystal prepared K+...
Faithful inheritance of parental histones is essential to maintain epigenetic information and cellular identity during cell division. Parental are evenly deposited onto the replicating DNA sister chromatids in a process dependent on MCM2 subunit helicase. However, impact aberrant histone partition human disease such as cancer largely unknown. In this study, we construct model impaired by introducing MCM2-2A mutation (defective binding) MCF-7 breast cells. The resulting reprograms...
Chromatin replication is intricately intertwined with the recycling of parental histones to newly duplicated DNA strands for faithful genetic and epigenetic inheritance. The transfer occurs through two distinct pathways: leading strand deposition, mediated by polymerase ε subunits Dpb3/Dpb4, lagging facilitated MCM helicase subunit Mcm2. However, mechanism facilitation Mcm2 transferring while moving along remains unclear. Here, we show that deletion Pol32, a nonessential major lagging-strand...
Prostate-specific membrane antigen (PSMA) is a prostate cancer target that plays crucial role in diagnosis and therapy. Herein, novel dual-targeted imaging probe, [68Ga]Ga-FAPI-PSMA, was prepared by radiolabeling conjugated DOTA-FAPI-PSMA with the short half-life radionuclide gallium-68 (68Ga), which dedicated to diagnostic imaging. In vitro, [68Ga]Ga-FAPI-PSMA had higher affinity for PSMA FAP high-expressing cell lines 22Rv1 U87 MG IC50 values of 4.73 2.10 nM, respectively, than...
Impact of crowding: Molecular crowding with poly(ethylene glycol) (PEG) induces the formation a G-quadruplex structure in guanine-rich strand telomeric DNA at K+-ion concentration that is unable to induce alone. The picture shows folding and unfolding DNA, revealed by fluorescence resonance energy transfer (FRET), efficiency which inversely dependent on distance between donor (D) acceptor (A).
Human chromosome ends are protected with kilobases repeats of TTAGGG. Telomere DNA shortens at replication. This shortening in most tumor cells is compensated by telomerase that adds telomere to the 3' end G-rich strand. Four TTAGGG can fold into G-quadruplex a poor substrate for telomerase. property has been suggested regulate activity vivo and inhibition via stabilization considered therapeutic strategy against cancer. Theoretically form anywhere along long Where forms determines whether...
Abstract Genomic Knowledgebase (GenomicKB) is a graph database for researchers to explore and investigate human genome, epigenome, transcriptome, 4D nucleome with simple efficient queries. The uses knowledge consolidate genomic datasets annotations from over 30 consortia portals, including 347 million entities, 1.36 billion relations, 3.9 entity relation properties. GenomicKB equipped web-based query system (https://gkb.dcmb.med.umich.edu/) which allows users the customized patterns specific...
Abstract The BLADE-ON-PETIOLE (BOP) genes of Arabidopsis (Arabidopsis thaliana) have been shown to play an essential role in floral abscission by specializing the zone (AZ) anatomy. However, molecular and cellular mechanisms that underlie differentiation AZ are largely unknown. In this study, we identified a tobacco (Nicotiana tabacum) homolog BOP (designated NtBOP2) characterized its function. plants, NtBOP2 gene is predominantly expressed at base corolla ethylene-independent manner. Both...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructures and properties of copper(II) copper(I) complexes containing an ethane-bridged dimeric phenanthroline ligandYuan Yao, Marc W. Perkovic, D. Paul Rillema, Clifton WoodsCite this: Inorg. Chem. 1992, 31, 19, 3956–3962Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/ic00045a019https://doi.org/10.1021/ic00045a019research-articleACS...
Meiotic recombination ensures accurate homologous chromosome segregation during meiosis and generates novel allelic combinations among gametes. During meiosis, DNA double strand breaks (DSBs) are generated to facilitate recombination. To maintain genome integrity, meiotic DSBs must be repaired using appropriate templates. Although the damage response protein kinase ATM (Ataxia-telangiectasia mutated) has been shown involved in Arabidopsis, its mechanistic role is still unclear. In this...
Abstract The resolution of chromatin conformation capture technologies keeps increasing, and the recent nucleosome contact maps allow us to explore how fine-scale 3D organization is related epigenomic states in human cells. Using publicly available Micro-C datasets, we develop a deep learning model, CAESAR, learn mapping function from features organization. model accurately predicts structures, such as short-range loops stripes, that Hi-C fails detect. With existing datasets ENCODE Roadmap...
First-price auctions have recently gained significant traction in digital advertising markets, exemplified by Google's transition from second-price to first-price auctions. Unlike auctions, where bidding one's private valuation is a dominant strategy, determining an optimal strategy more complex. From learning perspective, the learner (a specific bidder) can interact with environment (other bidders) sequentially infer their behaviors. Existing research often assumes environmental conditions...
Background Immune checkpoint inhibitors (ICIs) have been transformative in the treatment of patients with metastatic melanoma, but primary and secondary resistance to ICI is common. One key mechanism for skewing immune response from a cytotoxic (Th1) chronic inflammatory (Th2) profile. The small molecule ibrutinib dual-target agent that inhibits Bruton’s Tyrosine Kinase (BTK) Interleukin-2-inducible T-cell (ITK), regulator Th2 immunity. Therefore, combining pembrolizumab could potentially...
Objective To analyze the epidemiological characteristics of Hand, Foot and Mouth Disease (HFMD) reinfection its influencing factors in Jiulongpo District from 2009 to 2023 provide targeted prevention control recommendations for key factors. Methods HFMD cases Chongqing were derived China Information System Control Prevention 2023. Descriptive analysis was used reinfection, spatial autocorrelation regional clustering, binary logistic regression Results From 2023, 4,764 involving 2,436...
Accurate parental histone recycling is of pivotal importance in epigenetic inheritance. Its proper functioning hinges on the precise co-ordination among a diverse array proteins. During DNA replication, any aberration distribution histones can potentially result loss memory. To date, although several key proteins involved have been identified, detailed molecular mechanisms underlying their functions remain elusive. This mini-review focuses summarizing synchrony between replication and...
Long non-coding RNA (lncRNA) plays crucial role in osteogenic differentiation of bone marrow mesenchymal stem cells (BMMSCs), involving regulation competing endogenous (ceRNA) mechanisms and conduction signaling pathways. However, its are poorly understood. This study aimed to investigate lncRNAs, miRNAs mRNAs expression profiles rat BMMSCs (rBMMSCs) differentiation, screen the potential key lncRNA-miRNA-mRNA networks, explore putative functions identify molecules, as basis studying...
Single-crystalline Sb 2 S 3 rods were successfully used to fabricate high-performance photodetector after surface cleaning and defect suppression through post-annealing in H /Ar atmosphere.
Telomere length homeostasis is a prerequisite for the generation and growth of cancer. In >85% cancer cells, telomere maintained by telomerase that add repeats to end DNA. Because G-rich strand DNA can fold into G-quadruplex inhibits activity, stabilizing quadruplex small molecules emerging as potential therapeutic strategy against these applications, specificity toward over other forms an important property ensure no processes than elongation are interrupted. The evaluating assays currently...