A5017363343- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Peptidase Inhibition and Analysis
- Prostate Cancer Treatment and Research
- Amino Acid Enzymes and Metabolism
- Cancer Immunotherapy and Biomarkers
- Fluorine in Organic Chemistry
- Monoclonal and Polyclonal Antibodies Research
- Lanthanide and Transition Metal Complexes
- Supramolecular Self-Assembly in Materials
- Video Surveillance and Tracking Methods
- Cancer, Hypoxia, and Metabolism
- Neurotransmitter Receptor Influence on Behavior
- Food Quality and Safety Studies
- CAR-T cell therapy research
- Neuroscience and Neuropharmacology Research
- Chemical Reactions and Isotopes
- Supramolecular Chemistry and Complexes
- Advanced Image and Video Retrieval Techniques
- Advanced Neural Network Applications
- Water Quality Monitoring Technologies
- Thyroid and Parathyroid Surgery
- Polyamine Metabolism and Applications
- Ferroptosis and cancer prognosis
- Inclusion and Disability in Education and Sport
Tianjin University of Science and Technology
2024-2025
China International Science and Technology Cooperation
2024-2025
Peking University Cancer Hospital
2021-2024
Peking University
2020-2024
National Medical Products Administration
2021-2024
Hebei Medical University
2022-2024
Fourth Hospital of Hebei Medical University
2022-2024
Ludong University
2024
State Grid Corporation of China (China)
2021-2023
Guizhou Academy of Agricultural Sciences
2021
Prostate-specific membrane antigen (PSMA) is a prostate cancer target that plays crucial role in diagnosis and therapy. Herein, novel dual-targeted imaging probe, [68Ga]Ga-FAPI-PSMA, was prepared by radiolabeling conjugated DOTA-FAPI-PSMA with the short half-life radionuclide gallium-68 (68Ga), which dedicated to diagnostic imaging. In vitro, [68Ga]Ga-FAPI-PSMA had higher affinity for PSMA FAP high-expressing cell lines 22Rv1 U87 MG IC50 values of 4.73 2.10 nM, respectively, than...
In an effort to seek novel agents targeting prostate-specific membrane antigen (PSMA), 16 ligands (L1–L16) with structural modifications in S1′ binding pocket were synthesized and evaluated for PSMA inhibition. (S)-3-(Carboxyformamido)-2-(3-(carboxymethyl)ureido)propanoic acids proved be potent Ki values ranging from 0.08 nM 8.98 nM, which are the range of or higher potency compared previously published urea-based ligands. Computational docking was performed study mode two most discovered....
Abstract Background Bacterial nanocellulose (BNC), a natural polymer material, gained significant popularity among researchers and industry. It has great potential in areas, such as textile manufacturing, fiber-based paper, packaging products, food industry, biomedical materials, advanced functional bionanocomposites. The main current fermentation methods for BNC involved static culture, the agitated culture had lower raw material conversion rates resulted non-uniform product formation....
Carbonic anhydrase IX (CAIX), a zinc metal transmembrane protein, is highly expressed in 95% of clear cell renal carcinomas (ccRCCs). A positron emission tomography (PET) probe designed to target CAIX nuclear medicine imaging technology can achieve precise positioning, noninvasive, and be used monitor expression lesions real time. In this study, we constructed novel acetazolamide dual-targeted small-molecule [
Pancreatic ductal adenocarcinoma (PDAC), which has a poor prognosis and nonspecific symptoms progresses rapidly, is the most common pancreatic cancer type. Inhibitors targeting KRAS G12D G12C mutations have been pivotal in PDAC treatment. Cancer cells with different exhibit various degrees of glutamine dependency; particular, increased uptake. (2S,4R)-4-[18F]FGln recently developed for clinical diagnosis tumor cell metabolism analysis. Thus, we verified heterogeneity dependency models by...
Flavonoids are widely found in plants and diets considered to possess a variety of biological activities. Therefore, this study, 8 novel compounds derivating from the precursor compound 1a, were designed synthesized, their activities against ulcerative colitis(UC) evaluated provide most active molecule 2d. Both cellular inflammation model by LPS(Lipopolysaccharide)-induced RAW 264.7 cells UC 2 % Dextran Sulfate Sodium(DSS) intragastrically injected mice established employed detect validate...
In this paper, questionnaire survey and data analysis are the main research methods. Its purpose is to try answer question "why disabled people willing participate in sports" explore some of important factors that affect participation persons with disabilities. The object study 83 table tennis players national training base. "Questionnaire Motivation Adapted Athletes (AQAM)" an international standard. Through descriptive independent sample T test analysis, concludes three points: 1)...
Activated T cells played critical roles in immunotherapy and adoptive cell therapy, a non-invasive imaging strategy can provide us useful information concerning the transportation, accumulation, homing of vivo. In this paper, by utilizing long half-life radionuclide iodine-124 (124I) CD25 specific monoclonal antibody Basiliximab, we have fabricated novel probe, namely, 124I-Basiliximab, which was highly promising immuno-PET cells. vitro, 124I-Basiliximab had superior affinity to protein (Kd...
The Marine Environment Pollution Monitoring (MEPM) program has been carried out to demonstrate the capability of microwave radiometers for remote sensing oil spills. An airborne radiometer (AMR-OS) and a ship-based K-band were used detect spills estimate volume. Also coordinate sea-surface measurement on HJ-69 experiment-ship made acquire relative physical characters. This paper describes brief characters AMR-OS presents relationships between frequency thickness, brightness temperature...
Positron emission tomography imaging of serotonin transporter (SERT) is useful for studying brain diseases with altered serotonergic function. A deuterated agent, ([ 18 F]2‐((2‐((bis(methyl‐ d 3 )amino)methyl)‐4‐(3‐fluoropropoxy‐1,1,2,2,3,3‐ 6 )phenyl)thio)aniline, [ F]D12FPBM, F] 1 ), was prepared as a new chemical entity. The , showed excellent binding affinity to SERT; Ki 0.086 nM, comparable the undeuterated FPBM. In vivo biodistribution studies in rats good uptake (1.09% dose/g at 2 min...